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Improving levodopa-based complications to advance Parkinson's Disease therapies

29 Sep 04

The pharmaceutical market for the treatment of neurodegenerative disorders will grow by an unprecedented amount over the next ten years. The aging of the baby-boom generation, combined with new and improved treatments for neurodegenerative disorders such as Alzheimer's and Parkinson's disease will lead to an expansion of the already $30 billion neurodegenerative market. Despite the growth of generic products, Parkinson's disease drug revenues grew an impressive 17% across the seven major markets
LeadDiscovery

Sankyo's angiotensin II receptor blocker (ARB) olmesartan medoxomil demonstrates antiinflammatory activity in hypertensive patients.

22 Sep 04

Earlier this year data was reported that Sankyo's angiotensin II receptor blocker (ARB) olmesartan medoxomil may offer improved anti-hypertensive activity when compared to other therapeutic agents within this highly competitive $31 billion market. More recently clinical data has appeared that shows olmesartan to have additional anti- inflammatory activity in hypertensive patients with vascular inflammation. This may confer additional therapeutic benefit since inflammation is an etiological compo
LeadDiscovery

Advances in the development of corticotropin-releasing-hormone (CRH) receptor agonists as candidate analgesics

21 Sep 04

It has been estimated that 9% of the US population suffers from moderate to severe non-cancer-related pain. Acute pain resulting from conditions such as headache, muscle spasms, dental problems or following surgery, affects 90 million Americans every year and the development of analgesics represents a major pharmaceutical objective. A recent study has demonstrated the analgesic activity of corticotropin-releasing-hormone (CRH) and has shown that this activity is probably due to activity within t
LeadDiscovery

Developing therapeutic agents for the treatment of early (premature) ejaculation

21 Sep 04

Early ejaculation represents a major market, and indeed in 18-65 year olds it represents the predominant sexual dysfunction, affecting at least 20% of men. The global annual market for the treatment of early ejaculation has been estimated at $4 billion. However due to the absence of readily available therapeutics fewer than 10% of patients seek treatment for early ejaculation. Successful pharmaceutical development in this field may therefore reap immense rewards. Drug development has however bee
LeadDiscovery

Fujisawa's FK-866 reduces the growth and vascularization of renal cell carcinomas and also tumor metastasic

21 Sep 04

Renal cell carcinoma (RCC) is a niche cancer that accounts for 2-3% of all solid tumors in the major pharmaceutical markets. Approximately 30,000 patients are diagnosed with the disease each year in the US and 12,000 patients die of the disease annually. The market is currently dominated by the cytokines, but there is significant interest among physicians in the potential of anti-angiogenics, particularly so since renal cell carcinomas are known to be well vascularized. Researchers have now show
LeadDiscovery

Development of anti-CD154 monoclonal antibodies for the prevention of transplant rejection

21 Sep 04

The recent success of monoclonal antibody therapies such as Genentech's Rituxan and Johnson & Johnson's Remicade are driving further development of this field. MAb therapies brought in revenues of over $5.1 billion in 2003, a figure which should nearly triple over the next five years as new MAbs are launched and following the approval of new indications for MAbs already on the market. By 2008, MAbs should account for 32 percent of all revenue in the biotech market. One therapeutic antibody indic
LeadDiscovery

IL-27 as an exciting new target for cancer immunotherapy

21 Sep 04

In 2002 nearly 1,285,000 new cancer cases were diagnosed in the United States, and due to the lack of options for the treatment of advanced disease more than 550,000 Americans died of the disease. Immunotherapy represents an emerging approach to the treatment of cancer that promises high specificity with negligible side effects. This approach to cancer treatment commonly involves the stimulation of T cells and antibody production and the use of cytokines has been extensively studied. IL-12 has b
LeadDiscovery

Berlex researchers develop lipoxin A4 (LXA4) mimics for the treatment of inflammation

21 Sep 04

Treatments for inflammatory diseases comprise a $20 billion market spanning diseases such as psoriasis, asthma, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease. Both the prostaglandins and the leukotrienes are involved in the initiation and maintenance of inflammatory responses however agents that center on these mediators have produced limited therapeutic efficacy in various inflammatory disease settings. Harnessing the properties of anti-inflammatory mediators such as l
LeadDiscovery

Emerging Drug Discovery Targets: 21st September

21 Sep 04

Emerging Drug Discovery Targets provides a regular summary of some of the most exciting breaking information recently featured by the pharmaceutical analysts, LeadDiscovery. Information includes editorials on recently published journal articles, selected press releases and "intelligence reports". This edition features an LXA4 mimic for the treatment of inflammation; IL-27 as a cancer immunotherapy; anti-CD154 for organ transplant; CRH agonists for the treatment of pain; and an effective therapy
LeadDiscovery

Annual Update: Clinical Research in the UK 2004 – 2005

20 Sep 04

On Thursday 25th November 2004 Clinical Events will be hosting the next in the series of annual seminars focusing on the future of leading edge clinical research in the UK. This is following on from the success of last year’s Annual Update. Clinical Events Professional Development Seminars cover a wide range of drug development topics. Seminar delegates comprise individuals working in most departments of pharmaceutical and biotech companies.
Joanne Williams

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