01 Jul 05
Cell cycle inhibitors represent a key approach to the treatment of cancer. Therapeutic agents have traditionally targeted early stages of the cell cycle (ie the G1/S phase checkpoint or the S phase) or mitotic spindle formation as exemplified by the alkaloids. Recently a new approach to cell cycle regulation has emerged with the identification of the Aurora kinase family. This report evaluates this exciting area of drug discovery
29 Jun 05
Welcome to the June edition of TherapeuticAdvances, LeadDiscovery's free newsletter for the drug development sector. Read on for editorial comment on selected studies recently featured on DailyUpdates our regular bulletin of breaking journal articles and drug development news
28 Jun 05
Despite recent advances in the treatment and management of hepatitis B, the market is still relatively immature, with several key unmet needs. Current pipeline products are expected to account for 89% of total market sales by 2015, however other developmental antivirals are also expected to contribute significantly to future market growth, potentially resulting in new treatment paradigms.
17 Jun 05
Novartis has unveiled promising Phase II data for its once-daily bronchodilator, indacaterol (QAB-149). With a long duration of action, rapid onset of action and clean side effects profile, the drug could provide a new standard for bronchodilator therapy in patients with asthma and chronic obstructive pulmonary disease (COPD).
17 Jun 05
The ancient Egyptians thought that diabetes was due to an ‘imbalance of the four bodily elements’ and that the best treatment to give these patients was a mixture of ground earth, water, wheat and lead. Thankfully, things have improved a little since then! In fact, the most important advance in diabetes management occurred in 1921 when the young surgeon Frederick Banting and the even younger medical student, Charles Best, first isolated insulin.
16 Jun 05
Don’t take it personally if customers seem more paranoid in your presence these days. There have been a number of directives governing their interaction with the pharmaceutical industry. This has made many of them uneasy and indeed uncertain about what they can do and say in the presence of a medical sales person.
10 Jun 05
Stroke is the third leading cause of death in adults in developed countries. It can also leave survivors severely disabled and dependent on long-term care, placing an enormous financial burden on national healthcare systems. This burden is likely to further increase as the incidence of stroke increases concurrent with the aging population.
08 Jun 05
Fewer than 10% of people state that they have never had a headache.1 A recent UK survey identified 7.6% of males and 18.3% of females with migraine within the preceding year.2 Prevalence of migraine was shown to vary with age, rising through early adult life and declining in the late 40s and early 50s. Migraineurs reported at least one migraine attack per month on average, and most experienced interference with daily activities in at least 50% of their attacks.
CSF Medical Communications
08 Jun 05
The winner of the coveted title of Business of the Year at the 2005 Royal Borough Business Excellence Awards was crowned last week at the awards evening. The team at Pharmalink Consulting was congratulated by David Demolder, of award sponsor Ascot Racecourse for the overall quality of their business.
03 Jun 05
Of the 27 drugs currently in the HIV clinical development pipeline, the majority are in either Phase II trials or earlier. While the pipeline is considered strong, it is unlikely that any major treatment advances will be made before 2009/10. In fact, two of the more advanced drugs in terms of development - tipranavir and capravine - are likely to be used merely as 'holding drugs'.
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