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Features

Features
NVP-LAQ824 a novel histone deacetylase inhibitor

19 Nov 03

The field of histone deacetylation continues to receive considerable interest principally due to the ability of histone deacetylase (HDAC) inhibitors to produce cytostatic activity in cancer, but more recently due to the role that this class has in other indications such as autoimmune disorders. Novartis researchers have now developed a HDAC inhibitor of greater anti-proliferative potency than that of SAHA, and which almost completely blocked the growth of human colon and lung cancer xenografts
LeadDiscovery

Pharma NewsBytes: Oct 27nd- Nov 17th

19 Nov 03

Pharma NewsBytes selects out what we consider as being some of the most interesting press releases to have appeared on our DailyUpdates tracking service over the past few weeks. Currently featured new items focus on development activity in the field of rheumatoid arthritis; advances in anti-hyperlipemia therapeutics; and the termination of MK-0869 development for the treatment of depression
LeadDiscovery

Rheumatoid arthritis: Emerging drug discovery targets and therapeutic candidates

04 Nov 03

It is predicted that the annual value of the market for drugs used to treat autoimmune disease will exceed $20 billion in the next few years. Rheumatoid arthritis is one of the more common and difficult to treat autoimmune diseases and there is a great deal of interest in the discovery of novel drugs to treat this condition. This comprehensive report evaluates breaking drug discovery targets and therapeutic candidates for the treatment of this disease
LeadDiscovery

Meningitis: Tackling a Global Threat

21 Oct 03

Despite the media publicity that meningitis attracts when there is an outbreak, it remains one of the most serious infectious diseases facing the world - affecting populations in affluent and poorer countries alike.
Dr Faiz Kermani

Encouraging Mergers & Acquisitions in the UK Biotech Sector

21 Oct 03

It is clear that the UK biotechnology industry is undergoing widespread consolidation, driven by difficulties in raising capital to fund research programmes.
Dr Christopher Baxter-Jones and Mark Sharp

Emerging Drug Discovery Targets: 21st Oct

21 Oct 03

Emerging Drug Discovery Targets" provides a twice monthly summary of some of the most exciting breaking information recently featured by the pharmaceutical analysts, LeadDiscovery. This edition of features data highlighting technology for improved wound healing; a new candidate asthma treatment; a novel approach to diabetes and combination therapy offering improved radiotherapy responsiveness. As usual we also provide updates on industrial advances and licensing opportunities.
LeadDiscovery

Cx43 as a target for improved wound healing

15 Oct 03

Worldwide, 95 million people suffer from wounds that result in tissue loss. Wound healing problems extend hospital stays, especially in the elderly, resulting in an additional $1.5 billion in healthcare costs in the US alone. LeadDiscovery’s current target of the month focuses on connexin43, blocking of which produces a dramatic improvement in wound healing. In this feature we also describe how antisense technology has been applied to develop a licensing opportunity in this area
LeadDiscovery

Global pharmaceutical parallel trade: Can it ever happen?

15 Oct 03

One of the most controversial issues in international healthcare is the practice of parallel trade of pharmaceuticals. Parallel trade, sometimes known as the 'grey market', involves the cross border trade in a given product in parallel to a manufacturer's official main supply chain in that country.
Nathan Jessop

Pharma NewsBytes - Oct 13

15 Oct 03

Pharma NewsBytes is LeadDiscovery’s selection of recent press releases for the drug development. Currently featured news items include those announcing promising clinical data for Antigenics' pancreatic cancer Oncophage vaccine; FDA backing for Forest's new Alzheimer's disease drug, Memantine; early figures on the sale of AstraZeneca's anti-cholerstremic drug Crestor; and FDA approval of Pfizer's potential blockbuster, Inspira for the treatment of congestive heart failure
LeadDiscovery

Puppet, partner or parasite?

14 Oct 03

The role of clinical recruitment agencies may be perceived in different ways, but there is a clear demand for expertise delivered in an open and transparent fashion. Agencies must therefore work in partnership, not in parallel, with customers.
Sylvia Kempsell

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