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Features

Features
HDAC7 : A novel target for autoimmune disorders

07 Jul 03

The pharmaceutical industry is currently sinking considerable resources into the treatment of autoimmune disorders. One new candidate target is the histone deacetylase, HDAC7, reviewed in LeadDiscovery’s Target of the Month for July. HDAC7 inhibits Nur77 expression, a key regulator of T cell receptor mediated T cell apoptosis. Blocking HDAC7 can potentialy enhance apoptosis of autoreactive T cells and HDAC7 inhibitors may therefore be candidate treatments of autoimmune disorders.
LeadDiscovey

Idec and Biogen: a natural union?

30 Jun 03

Biogen and Idec Pharmaceuticals are set to merge in a stock-for-stock transaction valued at over $6.6 billion following announcements made earlier this week. The deal will create the third largest biotech firm in the world, yet Wall Street has so far appeared unimpressed by the deal. Even individual analysts seem to be disagreeing as to the strategic sense of the partnership.
Michael Randle

Partnerships in Clinical Research

10 Jun 03

At every stage of the R&D process, the companies must evaluate the time, logistics, expense and expertise that they can allocate. This also entails knowing when to rely on in-house capabilities and wh
Dr Faiz Kermani

Target of the Month

10 Jun 03

Uncontrolled proliferation is a common feature of malignant cells. Proliferation correlates with a nuclear protein known as Ki-67. Researchers have now shown that an antisense oligonucleotide against
LeadDiscovery

The Oncology Collection

03 Jun 03

To mark the American Society of Clinical Oncology's 2003 conference, LeadDiscovery has launched The Oncology Collection. The Oncology Collection groups all of LeadDiscovery's oncology services in one
LeadDiscovery

Zetia: Potential to reshape the cholesterol drug l

30 May 03

Statins have become the gold standard in the treatment of dyslipidemia, accounting for approximately 60% of treatments prescribed to patients with coronary heart disease in the late 1990s. However, wi
Michael Randle

Cymbalta: Eli Lilly to return to antidepressant ma

23 May 03

Eli Lilly and Company is set to launch Cymbalta into the depression and stress urinary incontinence markets in mid-2003. Datamonitor analyzes whether the company most synonymous with the antidepressan
Michael Randle

Australian e-Detailing Market

21 May 03

An extensive study carried out by Frost & Sullivan has revealed the tremendous potential for e-Detailing technology in Australia.
Jessinta Joseph Govan

Advances in ion channel drug discovery

20 May 03

A highly targeted library is available for the screening of potassium channel blockers or potassium channel openers
LeadDiscovery

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