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1248 Features
Emerging Drug Discovery Targets

01 Oct 03

"Emerging Drug Discovery Targets" summarizes the most exciting breaking information recently featured by the pharmaceutical analysts, LeadDiscovery. This edition explores recent advances in the use of siRNA technology in oncology, new molecular targets for the treatment of diabetes and advances in the development of GSK-3 inhibitors. Recent preselected press releases are also highlighted and as usual new licensing opportunities, breaking publications and new industry reports are all identified.

Development of Glycogen synthase kinase-3 (GSK-3) inhibitors by GlaxoSmithKline and by Johnson & Johnson (Target of the Month, TherapeuticAdvances, September, 2003)

25 Sep 03

Proof of concept studies have accumulated supporting the targeting of glycogen synthase kinase-3 (GSK-3) for the treatment of diabetes and CNS conditions. Now inhibitors are emerging as therapeutic candidates

Ghrelin: Pharmaceutical & Therapeutic Opportunities for the Treatment of Obesity

23 Sep 03

"Ghrelin: Pharmaceutical & Therapeutic Opportunities for the Treatment of Obesity" represents a cutting edge analysis of why and how ghrelin should be targeted for the identification of new therapies for obesity

Drug Rep Success - Book review

16 Sep 03

‘Drug Rep Success’ is the most complete of the numerous books published in the last 18 months or so that purport to offer guidance to the wannabe Medical Sales Rep and enhance the productivity of the established rep.
Mark Stacey

Why Corporate Images Need More Than A Quick Face Lift

15 Sep 03

As businesses start to get ready for the next up-cycle, new Names Identities and Images are underway. Big time branding failures and silly naming of the recent past taught marketers some key lessons. Here, is a quick guide to test any Name Identity in use or being planned for the upswing.
Naseem Javed

Winning through the web

09 Sep 03

Pharmiweb's first online recruitment training day saw a group of seasoned recruiters and HR professionals studying and workshopping ideas for more effective online recruitment in a one day session.
Mark Stacey

The Ayurveda Approach to Menopause and Natural Hormone Replacement Therapy.

03 Sep 03

The medical community is quickly evolving its understanding of menopause. Following the abrupt, early halt to the HRT portion of the Women's Health Initiative last July, due to findings that Hormone Replacement Therapy's risks outweighed its benefits, headlines now read
Nancy Lonsdorf M.D.

The importance of information control for compliance in the pharmaceuticals industry

27 Aug 03

Tim Taylor, Chief Business Development Officer at McLaren, looks at the role that IT can play in the improvement of process automation and control to positively benefit business strategies. An effective information management strategy can support companies, rather than hamper them, enabling them to build an organisation and systems that can manage extended global business applications in a compliant and efficient fashion.
Tim Taylor

The Outlook for Gene Therapy

26 Aug 03

As it aims to correct the underlying genetic defects in human disease rather than just focusing on symptoms, gene therapy offers the potential for actual cures. However, several technical and safety issues have hampered progress.
Dr Faiz Kermani

Has Biotech become less attractive?

21 Aug 03

Given the financing crisis in European biotech, how will the next wave of biotechs attract the necessary talent from pharma?
Carolyn Douthwaite

Biotech boom for Japan?

15 Aug 03

Some of the world’s leading drugs, such as Bristol-Myers Squibb’s pravastatin for high cholesterol, TAP’s lansoprazole and Daiichi’s levofloxacin were discovered in Japanese laboratories. With this history of important drug research there is keen interest in biotechnology.
Dr Faiz Kermani

Pharma’s Fastest Growing Customer Base

15 Aug 03

The increase in life expectancy coupled with a decreasing birth rate will place considerable pressure on governments and healthcare providers. Governments are having to reassess how they allocate their healthcare spending given that on average, the over 65s require four times as much healthcare resources as younger people.
Dr Faiz Kermani

The Kv1.3 potassium channel as a target for multip

05 Aug 03

Research towards the development of ion channel modulators is booming. One exciting target is the Kv1.3 voltage activated potassium channel. Expressed by human T lymphocytes Kv1.3 is involved in proliferation and cytokine secretion. Animal studies have established Kv1.3 as a target for the unmet multiple sclerosis (MS) market. Further key proof of concept data has now emerged demonstrating the selective expression of this channel in myelin-reactive effector memory T cells from MS patients

Pharma NewsBytes (August, 2003)

05 Aug 03

Pharma NewsBytes is LeadDiscovery's summary of news items released from the pharmaceutical and biotech sector over the previous two weeks. This week we feature the FDA's backing of the statin, Crestor; a new agreement based on the development of HDAC inhibitors which could leed to imporved cancer therapeutics; a novel and highly promising approach to metabolic disease announced by Roche; emerging clinical data on what appears to be an effective treatment of primary liver cancer and more.....

Pharmaceutical Marketing: The Internet impact

29 Jul 03

Faced with rising costs, shortened product lifecycles and an increasing reliance on blockbuster drugs, pharmaceutical companies are turning towards innovative marketing campaigns and new channels to reach an increasingly demanding consumer audience. Offering particular potential, campaign management solutions are being introduced to establish profitable interactions with large numbers of consumers across multiple channels.
Michael Randle

Cancer: an old problem

29 Jul 03

Although elderly people have a higher incidence of the four major cancers than any other age group, there is a fundamental lack of knowledge regarding the treatment of this demographic, resulting in their under-treatment. Commercial opportunity therefore awaits any pharmaceutical company able to target the development of strategies aimed specifically at elderly patients.
Michael Randle

HDAC7 : A novel target for autoimmune disorders

07 Jul 03

The pharmaceutical industry is currently sinking considerable resources into the treatment of autoimmune disorders. One new candidate target is the histone deacetylase, HDAC7, reviewed in LeadDiscovery’s Target of the Month for July. HDAC7 inhibits Nur77 expression, a key regulator of T cell receptor mediated T cell apoptosis. Blocking HDAC7 can potentialy enhance apoptosis of autoreactive T cells and HDAC7 inhibitors may therefore be candidate treatments of autoimmune disorders.

Idec and Biogen: a natural union?

30 Jun 03

Biogen and Idec Pharmaceuticals are set to merge in a stock-for-stock transaction valued at over $6.6 billion following announcements made earlier this week. The deal will create the third largest biotech firm in the world, yet Wall Street has so far appeared unimpressed by the deal. Even individual analysts seem to be disagreeing as to the strategic sense of the partnership.
Michael Randle

Partnerships in Clinical Research

10 Jun 03

At every stage of the R&D process, the companies must evaluate the time, logistics, expense and expertise that they can allocate. This also entails knowing when to rely on in-house capabilities and wh
Dr Faiz Kermani

Target of the Month

10 Jun 03

Uncontrolled proliferation is a common feature of malignant cells. Proliferation correlates with a nuclear protein known as Ki-67. Researchers have now shown that an antisense oligonucleotide against

The Oncology Collection

03 Jun 03

To mark the American Society of Clinical Oncology's 2003 conference, LeadDiscovery has launched The Oncology Collection. The Oncology Collection groups all of LeadDiscovery's oncology services in one

Zetia: Potential to reshape the cholesterol drug l

30 May 03

Statins have become the gold standard in the treatment of dyslipidemia, accounting for approximately 60% of treatments prescribed to patients with coronary heart disease in the late 1990s. However, wi
Michael Randle

Cymbalta: Eli Lilly to return to antidepressant ma

23 May 03

Eli Lilly and Company is set to launch Cymbalta into the depression and stress urinary incontinence markets in mid-2003. Datamonitor analyzes whether the company most synonymous with the antidepressan
Michael Randle

Australian e-Detailing Market

21 May 03

An extensive study carried out by Frost & Sullivan has revealed the tremendous potential for e-Detailing technology in Australia.
Jessinta Joseph Govan

Advances in ion channel drug discovery

20 May 03

A highly targeted library is available for the screening of potassium channel blockers or potassium channel openers

Successful gene therapy of pulmonary hypertension

20 May 03

Canadian researchers have successfully treated animals with experimental pulmonary hypertension with a vector expressing the Kv1.5 potassium channel gene

The Swiss Success Story

16 May 03

Switzerland has been a major force in the development of new medicines for over a century. Around 5% of current global pharmaceutical R&D is attributable to Swiss companies.
Larry Hughes and Dr Faiz Kermani

AXESS welcomes the second edition of “Careers with

13 May 03

Many of our candidates benefited from the previous book, and we are sure that the new edition will build on this success
Ian Thomas

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