According to new research presented today at the American Rhinologic Society Annual Meeting, an estimated 28 million Americans are currently suffering from the symptoms of Chronic Rhinosinusitis (CRS) – a nasal inflammatory condition more common than heart disease, angina or asthma. Findings were released today from a large population-based epidemiological study. The study assessed the self-reported prevalence, severity, and patterns of CRS type illnesses in the general population, including their symptoms and the treatments they currently use to manage the disease. Conducted in collaboration between leading experts, OptiNose and Blockbuster Strategy Group, a diverse group of 10,336 adults representative of the general U.S. population (for example with regard to geography, socioeconomic status, gender, age) was surveyed about their health and symptoms. From the larger group, 791 people who reported the diagnostic symptoms of chronic nasal inflammatory disease received additional in-depth interview questions. Researchers studied the impact of the disease on the patient population, and patient satisfaction with current treatment options. One finding was that people who reported that they had the symptoms of CRS felt that their symptoms were not just chronic but also surprisingly severe (63% of subjects were categorized as “severe” sufferers, and 46% of the severe sufferers reported they were a 9 or 10 on a 0-10 scale).
“These findings help quantify what many of us who treat these patients have long known: CRS afflicts a surprisingly large percentage of the adult U.S. population, and can take a toll on people who have it. It is not the same as allergic rhinitis and it is not just a runny nose. This study also reveals the high level of ongoing frustration with symptom control that still exists despite current treatment options. We need more treatment options,” said James Palmer, M.D., an author of the study and Professor and Director of the Division of Rhinology at the University of Pennsylvania in Philadelphia and former Secretary of the American Rhinologic Society (ARS).
CRS affects the sinuses and the nasal cavity, including narrow passages deep in the nose, with chronic inflammation causing the same types of problems as it does in other parts of the body, including redness, pain, swelling, and damage to the inflamed surfaces. The inflamed areas may also have impaired ability to clear inhaled particles and pathogens, so infections and allergies may also be more frequent or severe. The symptoms of CRS can be moderate to severe, and by definition last for a minimum of eight consecutive weeks per year, though they may last for many months or years.
The Study also Found that:
The research was funded by OptiNose, a Specialty Pharmaceutical/Biotech Company that is using a unique nasal technology to develop new treatments in disease areas where there is a large population of patients whose needs are not being met with current treatment options.
OptiNose is a Specialty Biotechnology/Pharmaceutical Company developing a promising pipeline of new products. The Company’s patented closed-palate Breath Powered® technology is a platform for developing novel treatments that are aimed at creating meaningful benefits with high and deep intranasal deposition of medication. OptiNose developed and out-licensed a first product at the end of phase 3 (Onzetra™ Xsail™, licensed to Avanir in North America, since acquired by Otsuka Pharmaceutical Co). OptiNose is also in late stage development of an Exhalation Delivery System for fluticasone (OPN-375) for patients with chronic nasal inflammatory diseases, and has completed Phase 3 investigational studies in patients with chronic rhinosinusitis and nasal polyps. Other OptiNose pipeline products also target large markets with significant unmet need, including nose-to-brain technology applications such as OPN-300 for Autism. OptiNose has corporate offices in the US, Norway and the UK.
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Last updated on: 19/09/2016
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