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Press Release

PharmaMar Announces New Data with its Compounds Yondelis® and Lurbinectedin During ASCO 2017

PharmaMar
Posted on: 19 May 17

PR Newswire

MADRID, May 19, 2017

MADRID, May 19, 2017 /PRNewswire/ --

PharmaMar (MCE: PHM) will present data obtained from various clinical studies for its activated transcription inhibitors, Yondelis® and lurbinectedin, during the 53rd Congress of the American Society of Clinical Oncology (ASCO) that will be held from the 2nd to the 6th of June in Chicago (USA).  

     (Logo: http://photos.prnewswire.com/prnh/20150203/727958-b )

During this congress, PharmaMar will participate with various presentations for Yondelis® in malignant pleural mesothelioma, along with the data of a prospective study of the combination with radiotherapy in soft tissue sarcoma.

The Company will also present data for lurbinectedin (PM1183) for the treatment of endometrial cancer and BRCA 2-associated metastatic breast cancer. The results will also be presented on a Phase I study that evaluated the combination of lurbinectedin with olaparib in patients with advanced solid tumors.  

" After the positive results obtained in endometrial cancer with lurbinectedin, as a single agent and in combination with doxorubicin (abstract 6658), w e plan to initiate a pivotal Phase III study . We have reached an agreement with the US FDA on the design of the study " , explains Dr Arturo Soto, Head of Clinical Development at the Oncology Business Unit at PharmaMar. "We will continue withour commitment to finding innovative solutions for cancer patients from compounds of a marine origin that have the characteristic for combating cancer with a novel mechanism of action", states.

The studies presented during this congress are available on http://abstracts.asco.org

Principle studies to be presented at ASCO 2017 

Lurbinectedin 

  • Activity of lurbinectedin (PM01183) as single agent and in combination in patients with endometrial cancer. (Abstract 5586) 

Poster Board: #408. Saturday 3 of June from 13:15 to 16:45. Hall A    

Lead author: Martin David Forster, MBBS, MRCP, FRCP, PhD, University College London Hospitals

  • Antitumor activity of trabectedin and lurbinectedin in germline BRCA2 carriers with metastatic breast cancer (MBC) as compared to BRCA1 carriers: Analysis of two phase II trials. (Abstract 574)  

Poster Board: #174. Sunday, 4 of June from 8:30 to 11:30. Hall A

Lead author: Judith Balmana Gelpi, MD PhD, Hospital Vall d'Hebron

  • Phase I study to evaluate the tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) of PM01183 (Lurbinectedin) in combination with olaparib in patients with advanced solid tumors. (Abstract 5573) 

Poster Board: #395. Saturday, 3 of June from 13:15 to 16:45. Hall A  

Lead autjor: Andres Poveda, MD, Clinical Area of Gynecologic Oncology, Instituto Valenciano de Oncología (IVO)

Yondelis ® (trabectedin)  

  • Trabectedin (T) as second line treatment option for patients with epithelioid malignant pleural mesothelioma (MPM) in progression following pemetrexed/platin-derivates chemotherapy: ATREUS trial. (Abstract 8513) 

Poster Board: #249. Saturday, 3 of June from 13:15 to 14:30. Hall D2

Laed author: Diego Luigi Cortinovis, MD, Azienda Ospedaliera San Gerardo

  • Trabectedin for advanced soft tissue sarcoma: Ten-year real-life perspective. (Abstract 11060) 

Poster Board: #383. Sunday, 4 of June from 8:00 to 11:30. Hall A

Lead author: Sivan Shamai, MD, Tel Aviv Medical Center and Sackler School of Medicine

  • Trabectedin and radiotherapy in soft-tissue sarcoma (TRASTS) study: An international, prospective, phase I/II trial - A collaborative Spanish (GEIS), Italian (ISG), and French (FSG) groups study. (Abstract 11061) 

Poster Board: #384. Sunday, 4 of June from 8:00 to 11:30. Hall A

Laed author: Alessandro Gronchi, MD, Fondazione IRCCS Istituto Nazionale dei Tumori

  • Correlation between a new growth modulation index (GMI)-based Geistra score and efficacy outcomes in patients (PTS) with advanced soft tissue sarcomas (ASTS) treated with trabectedin (T): A Spanish group for research on sarcomas (GEIS-38 study). ( Abstract 11070) 

Poster Board: #393. Sunday, 4 of June from 8:00 to 11:30. Hall A  

Laed author: Javier Martinez-Trufero, PhD, Hospital Miguel Servet

  • Predictive role of FAS for trabectedin in second lines of advanced soft tissue sarcoma (ASTS): A Spanish group for research on sarcoma (GEIS) study. ( Abstract 11071)

Poster Board: #394. Sunday, 4 of June from 8:00 to 11:30. Hall A  

Laed author: Javier Martin Broto, MD, PhD, Virgen del Rocio University Hospital, Institute of Biomedicine Research (IBIS)

Media Relations (+34-638-79-62-15) and Investor Relations (+34-914444500)

SOURCE PharmaMar

PR Newswire
www.prnewswire.com

Last updated on: 19/05/2017

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