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Job Details

Vector Development Scientist (downstream process development)

Company: Chiltern
Location: Oxford
Reference: MLJ899031
Closing Date: 03 Feb 17
Type: Full Time
Salary (£): Negotiable
Benefits: Salaries are competitive; benefits include a pension scheme, life insurance, private health insurance and dental plan, subsidised gym membership

Job Summary:

Full Time Laboratory Based Permanent Scientific Position in Oxford. T- Cell Therapy (Oncology) Salaries are competitive; benefits include a pension scheme, life insurance, private health insurance and dental plan, subsidised gym membership and a flourishing social scene. To be involved in cutting-edge therapeutic research programmes, within a friendly, dynamic environment




My Client is a leader in the research and development of T cell-based therapies for the treatment of cancer. The business is rapidly growing in both the UK and USA and they have multiple early-phase clinical trials ongoing in oncology centres across both the US and Europe.

Based just outside Oxford, UK, the company offers the opportunity to take part in pioneering the commercial development of T cell therapy.  The company has an inventive and collaborative culture, where employees are valued and inspired as well as rewarded for their ideas and contributions. The organisation of research has created an environment where it is possible to make both individual and team contributions towards scientific excellence.

The role is to conduct scientific experiments as required within the Vector Development Group.   Whilst initially requiring supervision by a more senior scientist, the job holder will develop further scientific skills to be able to work independently on routine experiments.  The job holder will also be responsible for the interpretation of scientific results under the supervision of a senior scientist.

Functional focus: The Vector Development Group focuses on developing the process used to manufacture viral vectors for ex vivo genetic modification of T cells.  This also includes evaluating new technologies to improve the existing platform process. A robust and cost effective process is transferred to external contract manufacturer for clinical grade viral vector manufacture with further technical support from Vector Development group for troubleshooting.  Desirable skills includes viral vector production, mammalian cell culture, bioreactor, flow cytometry, ELISA, column chromatography, tangential flow filtration, real time PCR.


Conducting downstream biological material purification technique such as column chromatography, tangential flow filtration to support scientists and the Group as a whole.

Analyse, summarise and record experimental results, and maintain relevant databases and records.


Undergraduate degree in Lifesciences or related discipline, with at least 3 years relevant work experience.

Ability to learn and develop in order to work independently on routine experiments within a reasonable time frame and with minimal supervision.

Experience of live viral vector purification using column chromatography & tangential flow filtration methods.


Additional post-graduate scientific experience or qualifications, such as a M.Sc. or PhD

Skills & Competencies


Computer literate, excellent numeracy and English language skills (both written and verbal), team player attitude.

Basic experimental design skills, ability to follow protocols and use standard laboratory equipment.

Attention to detail and good time management skills.

Able to work independently after training.


Knowledge of viral vector production, column chromatography and tangential flow filtration and ELISA plate reader.

Please call Marc Joseph on 01753 216664 for further information and discussion or send CV to

key words vector development, oncology, t- cell therapy, Elisa, laboratory


Apply for this job: Vector Development Scientist (downstream process development)

Contact Information:

Address:  London, UK
171 Bath Road Slough Berkshire
Tel:  +44 (0) 1753 512000
Fax:  +44 (0) 1753 511116
Website:  Visit Our Web Site

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