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Job Details

Senior Scientist, Protein Scientist

Company: Astrazeneca
Location: Cambridge
Reference: R-013183
Closing Date: 27 Sep 17
Type: Permanent
Salary (£): Negotiable

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Job Summary:

Senior Research Scientist, Protein Scientist (Alderley Park/Cambridge, UK)Salary: CompetitiveLocation: Alderley Park/Cambridge At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. ...


Senior Research Scientist, Protein Scientist (Alderley Park/Cambridge, UK)

Salary: Competitive

Location: Alderley Park/Cambridge

At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe.

As a Senior Research Scientist in the Biochemical Reagents team, UK, you will play a pivotal role in channelling our scientific capabilities to make a positive impact on changing patients’ lives. IMED (Innovative Medicines and Early Development) focuses on scientific advances in small molecules, oligonucleotides and other emerging technologies and drug discovery platforms across our focus areas.

The Biochemical Reagents team is responsible for producing and characterising recombinant proteins which represent disease targets for all small molecule drug discovery projects in the IMED, with the UK team mainly focused on Oncology. Proteins are utilised for the development of biochemical assays for compound screening and structural/biophysical assays to characterise protein ligand interactions.

The role will ultimately be located at our brand new facility in Cambridge, but will be initially based at Alderley Park in Cheshire until 2019.

There is an exciting opportunity for a talented and motivated individual to join the group in a lab-based role. The successful individual will be a key member of the team, leading protein generation activities for a diverse range of projects across several disease areas and AstraZeneca sites globally.

Main Duties and Responsibilities

* To be a lab-based protein scientist, delivering expertise in the area of recombinant protein expression, purification and characterisation, while incorporating the views of others.
* To work in partnership with colleagues in Discovery Sciences and across therapy areas and sites to ensure the delivery of high quality protein reagents to projects
* To implement work-plans over agreed timelines such that the objectives of the project are met, including delivery of more than one agreed area of work in parallel where appropriate.
* To be an effective member of Drug Discovery Project Teams, contributing novel ideas and using judgment and knowledge where appropriate to influence the work of the project.
* To maintain an awareness of current developments in the literature and contribute to the continuous improvement process by identifying opportunities in the workplace where improvements can be made; may lead one or more aspects of scientific discipline within their team.
* To achieve personal scientific visibility through project contributions and internal presentations at departmental or functional meetings; and external scientific visibility through poster & oral conference presentations and authorship on peer-reviewed publications.

Essential Requirements

* Ph.D in Biology, Pharmacology, Biochemistry or a related discipline or a BSc/MSc degree with significant relevant experience, preferably in the pharmaceutical or biotechnology industry.
* Expertise in the area of Protein Science through a demonstrable knowledge of construct design, molecular biology, protein expression, purification, characterisation and structure function
* A practical understanding of a wide range of methods and technologies as applied to the expression, purification and characterisation of recombinant proteins. For example bacterial and insect cell expression, liquid chromatography, SDS-PAGE, mass spectrometry and biophysical techniques.
* Excellent problem solving skills, good scientific judgement and communication skills.
* Excellent team working and networking skills with experience of interacting effectively across interfaces of discipline, culture, and expertise.

Desirable Requirements

* Hands-on experience of mass spectrometry methods for protein QC, including peptide mapping, intact mass, native mass spectrometry
* Hands-on experience of biochemical assay development for target proteins
* Experience of working in external collaborations.

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

Reflecting our commitment to equal opportunities, we operate a gender-neutral CV screening process. Please submit your CV in Word format (rather than as a PDF) so gender details can be removed before it is forwarded to the hiring manager.

Opening date: 30th August 2017

Closing date: 29th September 2017

Apply for this job: Senior Scientist, Protein Scientist

Contact Information:

Address:  Cambridge Biomedical
Campus 1 Francis Crick Avenue Cambridge Cambridgeshire
Website:  Visit Our Web Site

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