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The Latest Pharma Jobs, News and Events today | 07 October 2015

Probiodrug signs agreement with Rentschler for manufacture of its pGlu-Abeta targeting antibody PBD-C06

Probiodrug AG (Euronext Amsterdam: PBD), a biopharmaceutical company developing novel therapeutic solutions to treat Alzheimer's disease (AD), has announced today an agreement with the German-based Biopharma Manufacturer Rentschler Biotechnologie GmbH to develop PBD-C06, a pGlu-Abeta-specific monoclonal antibody.

The contract comprises all stages of production and processing from initial cell line development through to the manufacturing of material for preclinical and clinical studies. Rentschler is a renowned independent contract manufacturer with an excellent track record of producing biopharmaceuticals for over 40 years....

PBD-C06 is a chimeric, de-immunized monoclonal antibody selected as a candidate with the best safety, efficacy and pharmacological profile from among several pre-clinical candidates. It targets pGlu-Abeta, aiming to selectively clear the brain of pGlu-Abeta while leaving non-toxic forms of Abeta untouched. In AD animal models PBD-C06 reduced pGlu-Abeta and total Abeta levels and positively affected memory function. 

Commenting on the announcement, Dr Inge Lues, Chief Development Officer at Probiodrug said: “Following our very satisfying preclinical proof of concept with our anti-pGlu Abeta antibody in various Alzheimer–like animal models, we have initiated an important step towards evaluating our lead antibody in a clinical setting. We are very pleased to work with Rentschler. Their experience and track record as a service-oriented biopharmaceutical manufacturing partner is well known, and they are committed to implementing Probiodrug’s aggressive project timelines.”

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