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735 Features
HIV infection - changes in epidemiology driving R&D development and increased market value

07 Oct 04

The demographics of HIV patients are shifting, with the average age of those infected with HIV ever increasing due to longer life expectancy and higher survival rates. However, with increasingly complex infections and drug resistance developing in long term patients, novel medications and new combinations are now being launched to continue the fight...
LeadDiscovery

Therapeutic activity of Bayer's BAY 43-9006 in renal cell carcinoma

05 Oct 04

Renal cell carcinoma (RCC) is a niche cancer that accounts for 2-3% of all solid tumors in the major pharmaceutical markets. Approximately 30,000 patients are diagnosed with the disease each year in the US and 12,000 patients die of the disease annually. The market is currently dominated by the cytokines, but there is significant interest among physicians in the potential of anti-angiogenics, particularly so since renal cell carcinomas are known to be well vascularized. Bayer's BAY 43-9006 is a
LeadDiscovery

COX-2 withdrawal - Therapeutic, R&D and pharmaceutical impact

01 Oct 04

As the dust settles on Merck's withdrawal of Vioxx's, LeadDiscovery investigates the impact that this will have on the treatment of pain, R&D activity directed towards the identification of new approaches, and on pharmaceutical sales relating to COX-2 inhibitors and related drug classes
LeadDiscovery

New molecular target identified for the prevention of Alzheimer's disease

30 Sep 04

The market for Alzheimer's therapy is expected to grow from 16 million patients to 21 million by 2010 in the seven major pharmaceutical markets. Alzheimer's disease market in the seven major markets is worth $4.7 billion and will increase to $6.1 billion by the year 2005 and $ 7.8 billion by the year 2010. The major unmet need in this market is for disease modification and disease prevention. Recent findings by British researchers showing that targeting the neuronal adaptor protein X11beta can r
LeadDiscovery

Improving levodopa-based complications to advance Parkinson's Disease therapies

29 Sep 04

The pharmaceutical market for the treatment of neurodegenerative disorders will grow by an unprecedented amount over the next ten years. The aging of the baby-boom generation, combined with new and improved treatments for neurodegenerative disorders such as Alzheimer's and Parkinson's disease will lead to an expansion of the already $30 billion neurodegenerative market. Despite the growth of generic products, Parkinson's disease drug revenues grew an impressive 17% across the seven major markets
LeadDiscovery

Unlocking China’s Pharma Potential

24 Sep 04

China is predicted to be a major pharmaceutical market in the future. However, like other emerging markets, there are a number of challenges that companies need to deal with in order to unlock its full potential.
Dr Faiz Kermani

Sankyo's angiotensin II receptor blocker (ARB) olmesartan medoxomil demonstrates antiinflammatory activity in hypertensive patients.

22 Sep 04

Earlier this year data was reported that Sankyo's angiotensin II receptor blocker (ARB) olmesartan medoxomil may offer improved anti-hypertensive activity when compared to other therapeutic agents within this highly competitive $31 billion market. More recently clinical data has appeared that shows olmesartan to have additional anti- inflammatory activity in hypertensive patients with vascular inflammation. This may confer additional therapeutic benefit since inflammation is an etiological compo
LeadDiscovery

Development of anti-CD154 monoclonal antibodies for the prevention of transplant rejection

21 Sep 04

The recent success of monoclonal antibody therapies such as Genentech's Rituxan and Johnson & Johnson's Remicade are driving further development of this field. MAb therapies brought in revenues of over $5.1 billion in 2003, a figure which should nearly triple over the next five years as new MAbs are launched and following the approval of new indications for MAbs already on the market. By 2008, MAbs should account for 32 percent of all revenue in the biotech market. One therapeutic antibody indic
LeadDiscovery

Fujisawa's FK-866 reduces the growth and vascularization of renal cell carcinomas and also tumor metastasic

21 Sep 04

Renal cell carcinoma (RCC) is a niche cancer that accounts for 2-3% of all solid tumors in the major pharmaceutical markets. Approximately 30,000 patients are diagnosed with the disease each year in the US and 12,000 patients die of the disease annually. The market is currently dominated by the cytokines, but there is significant interest among physicians in the potential of anti-angiogenics, particularly so since renal cell carcinomas are known to be well vascularized. Researchers have now show
LeadDiscovery

IL-27 as an exciting new target for cancer immunotherapy

21 Sep 04

In 2002 nearly 1,285,000 new cancer cases were diagnosed in the United States, and due to the lack of options for the treatment of advanced disease more than 550,000 Americans died of the disease. Immunotherapy represents an emerging approach to the treatment of cancer that promises high specificity with negligible side effects. This approach to cancer treatment commonly involves the stimulation of T cells and antibody production and the use of cytokines has been extensively studied. IL-12 has b
LeadDiscovery

Developing therapeutic agents for the treatment of early (premature) ejaculation

21 Sep 04

Early ejaculation represents a major market, and indeed in 18-65 year olds it represents the predominant sexual dysfunction, affecting at least 20% of men. The global annual market for the treatment of early ejaculation has been estimated at $4 billion. However due to the absence of readily available therapeutics fewer than 10% of patients seek treatment for early ejaculation. Successful pharmaceutical development in this field may therefore reap immense rewards. Drug development has however bee
LeadDiscovery

Berlex researchers develop lipoxin A4 (LXA4) mimics for the treatment of inflammation

21 Sep 04

Treatments for inflammatory diseases comprise a $20 billion market spanning diseases such as psoriasis, asthma, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease. Both the prostaglandins and the leukotrienes are involved in the initiation and maintenance of inflammatory responses however agents that center on these mediators have produced limited therapeutic efficacy in various inflammatory disease settings. Harnessing the properties of anti-inflammatory mediators such as l
LeadDiscovery

Advances in the development of corticotropin-releasing-hormone (CRH) receptor agonists as candidate analgesics

21 Sep 04

It has been estimated that 9% of the US population suffers from moderate to severe non-cancer-related pain. Acute pain resulting from conditions such as headache, muscle spasms, dental problems or following surgery, affects 90 million Americans every year and the development of analgesics represents a major pharmaceutical objective. A recent study has demonstrated the analgesic activity of corticotropin-releasing-hormone (CRH) and has shown that this activity is probably due to activity within t
LeadDiscovery

Emerging Drug Discovery Targets: 21st September

21 Sep 04

Emerging Drug Discovery Targets provides a regular summary of some of the most exciting breaking information recently featured by the pharmaceutical analysts, LeadDiscovery. Information includes editorials on recently published journal articles, selected press releases and "intelligence reports". This edition features an LXA4 mimic for the treatment of inflammation; IL-27 as a cancer immunotherapy; anti-CD154 for organ transplant; CRH agonists for the treatment of pain; and an effective therapy
LeadDiscovery

PharmaNews Bytes: Selected September press releases from the pharma/biotech sector

17 Sep 04

LeadDiscovery's intelligence service, DailyUpdates has evolved as a key tool to help all in the drug development sector keep track of breaking journal articles, press releases and pharmaceutical reports. Pharma NewsBytes features selected press releases recently featured on DailyUpdates and offers the reader a leisurely stroll through the past few weeks of activity from within the pharmaceutical industry.
LeadDiscovery

GlaxoSmithKline's IkappaB kinase 2 (IKK-2) inhibitor, TCPA-1 as a potential next generation disease modifying antirheumatic drug (DMARD) for the treatment of rheumatoid arthritis

15 Sep 04

The TNF blockers Enbrel (etanercept) and Remicade (infliximab), have contributed to a revolution in the treatment of rheumatoid arthritis. The drug development community is now expending considerable resources on developing next generation disease modifying antirheumatic drugs (DMARDs) with improved efficacy and safety as well as oral activity. GlaxoSmithKline's IkappaB kinase 2 (IKK-2) inhibitor, TCPA-1 has recently been developed and has shown considerable promise in early stage development.
LeadDiscovery

Patient compliance is a $30 billion complaint

13 Sep 04

We all forget to take medication from time to time, or maybe even don't bother to refill our prescriptions because we're feeling fine. However, the cumulative effect of all this is costing the pharmaceutical industry in excess of $30 billion a year. Datamonitor's Adele Schulz offers pharmaceutical companies some practical solutions to help stop the financial bleeding...
Datamonitor

Trials & Tribulations: Advances in the Development of Histone Deacetylase (HDAC) Inhibitors for the Treatment of Cancer

10 Sep 04

Histone deacetylase (HDAC) inhibitors, having received considerable R&D attention, are now being led through the clinic by SAHA which is currently in phase II development. A second HDAC inhibitor, Titan's Pivanex, has now been shown to be effective as a single agent therapeutic in patients with non-small cell lung cancer. Due to toxicity observed when used in combination with docetaxel, development for this indication has been terminated. Studies have however recently been initiated to investiga
LeadDiscovery

New study reveals that reversing albuminuria reduces cardiovascular events in patients with diabetic nephropathy

07 Sep 04

The RENAAL study, published in 2001 demonstrated that Merck's Losartan slows diabetic nephropathy and reduces the risk of heart failure. In a more recent analysis of the RENAAL database, researchers have shown that albuminuria predicts heart failure as well as other cardiovascular events and that the degree of success with which Losartan can reduce albumin levels is related to the extent of cardiovascular protection.
LeadDiscovery

Isotechnika's search for a partner continues

03 Sep 04

Isotechnika's Q2 loss shows a sharp reversal in fortunes. Profit in 2003 was largely attributable to a research payment for ISA247 from Roche, which has since pulled out of part of the deal. Isotechnika will be hoping that Roche continues to support ISA247 in the field of transplantation, but, says Datamonitor's Timothy Pang, it would be boosted by the cash that a new partner would bring...
Datamonitor

New research encourages changes in the treatment and prevention of deep vein thrombosis in cancer patients

03 Sep 04

Researchers at The University of Texas M.D. Anderson Cancer Center report that optimizing the use of anticoagulants in cancer patients with deep vein thrombosis could improve outcomes, reduce hospital stay and lower the cost of treatment. The study which gathered data from 529 cancer patients with deep vein thrombosis, and which represents the most comprehensive study of it kind, suggests that bleeding in treated patients and the reoccurrence of thrombosis is higher than previously reported. Fur
LeadDiscovery

Targeted therapies the aim for breast cancer treatment

01 Sep 04

Due to more and better screening practices leading to earlier diagnosis, survival rates for breast cancer have risen to as high as 87% in some developed countries. But globally, 380,000 people (mainly women) will still die from breast cancer in 2004. Datamonitor's Fleur Pijpers explains that in the future, new targeted therapies could lead to successful treatment for each individual patient...
Datamonitor

Selling the e-remedy

01 Sep 04

Pharmaceutical companies are increasingly looking to technology to increase sales, according to COLIN WILLIAMS, Head of Marketing at PharmiWeb Solutions...
Colin Williams

Dompe researchers develop chemokine receptor CXCR1 antagonist for the prevention of acute transplant rejection, chronic ischemic conditions and inflammatory disorders

31 Aug 04

Dompe researchers report the development of the chemokine receptor CXCR1 antagonist, repertaxin. New data show that Dompe's phase I candidate repertaxin dramatically reduces liver damage in a model of acute transplant rejection. By blocking neutrophil infiltration the therapeutic potential of repertaxin extends past the prevention of transplant rejection to cover a wide range of other indications including chronic ischemic conditions and inflammatory disorders.
LeadDiscovery

Toxicity problems continue to slow the development of CDK inhibitors

27 Aug 04

DailyUpdates 27th August, 2004: The inhibition of cyclin-dependent kinases (CDKs) represents an attractive approach to the treatment of cancer. Although this group of agents, led by Aventis' flavopiridol are poor monotherapeutic agents they exhibit sequence-dependent cytotoxic synergy when administered after standard chemotherapeutic drugs. Unfortunately, as demonstrated in a recent trial investigating the efficacy of a Taxotere-flavopiridol combination in metastatic breast cancer patients, toxi
LeadDiscovery

Pharmacological activation of transforming growth factor-beta1 (TGF-beta1) may be of benefit as a stroke prevention strategy

26 Aug 04

DailyUpdates 26th August, 2004: The stabilization of atherosclerotic plaques has emerged as a strategy for reducing the incidence of stroke as well as other cardiovascular diseases. Previous studies have reported that blocking the activity of transforming growth factor-beta1 (TGF-beta1) can limit the progression of atherosclerosis and stabilize plaques in animal models. New data now suggests that increasing TGF-beta1 can also stabilize plaques in humans supporting the development of therapeutic
LeadDiscovery

Peripheral Arterial Disease Represents a Significant and Rapidly Growing Market Opportunity for Interventional Therapies, Particularly Endovascular Technologies

26 Aug 04

ATLANTA--Aug. 25, 2004--Endovascular intervention, employing minimally invasive, catheter-based technologies, is expected to become the dominant therapeutic modality for atherosclerotic diseases in the lower limbs, according to a new report published by THE SAGE GROUP
LeadDiscovery

Clinical data further demonstrates the efficacy of Pfizer's pregabalin (Lyrica) in the treatment of diabetic neuropathic pain

25 Aug 04

DailyUpdates 25th August, 2004: Despite legal appeals by Pfizer, Ivax's generic equivalent of the blockbuster gabapentin (Neurontin) went on sale earlier this month increasing the need for Pfizer to push the follow-on, pregabalin onto the US market. Pregabalin was approved by European authorities in July of this year for the treatment of peripheral neuropathic pain and as an adjunctive therapy for partial seizures in patients with epilepsy. Most recently a US study has been published data furthe
LeadDiscovery

Low level carbon monoxide exposure as a therapeutic approach to improving transplant outcome

24 Aug 04

DailyUpdates 24th August, 2004: Heme oxygenase-1 (HO-1), one of the enzymes responsible for the production of carbon monoxide, is induced under conditions of ischemic stress. Clinical data has previously demonstrated that increased expression of HO-1 may limit post-transplant ischemia reperfusion injury, a major cause of reduced graft survival. Now researchers have reported that maintaining transplant recipients in an atmosphere of elevated carbon monoxide promotes extended graft survival
LeadDiscovery

Clinical data supports the development of insulin as a future treatment for memory and mood disorders?

23 Aug 04

DailyUpdates 23rd August, 2004: The use of insulin forms the cornerstone of diabetes treatment. A body of data also suggests however that this hormone directly modulates both memory and mood suggesting that endogenous insulin may be of benefit to many of the 180 million people around the world with memory disorders, and especially those with co-morbid mood disturbances such as schizophrenic or depressed individuals. A recent study has shown that intra-nasal administration of insulin improves m
LeadDiscovery

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