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651 Features
Taishi's 20-HETE synthesis inhibitor, TS-011 as a candidate acute treatment for hemorrhagic and ishemic stroke

28 Jul 05

Each year, 750,000 strokes occur in the US and resultant deaths account for stroke being one of the top three causes of mortality as well as a major economic burden on healthcare systems. One candidate molecular target for stroke is 20-HETE. Taisho Pharmaceutical have developed a potent and selective 20-HETE synthesis inhibitor, TS-011 for the treatment of stroke.
LeadDiscovery

Working in France

28 Jul 05

Tourists love France and why not you… to work and live in France.
Claire Armstrong i3 Pharma Resourcing

Vanilloid receptor desensitization as a strategy for improving glucose tolerance as well as reducing diabetic neuropathic pain

27 Jul 05

The vanilloid capsaicin has long been known to desensitize pain pathways leading to long-term analgesia. Recent data from Novo Nordisk A/S suggests that sensory afferents might also be implicated in the development of glucose intolerance.
LeadDiscovery

So You Want to Contract Staff?

27 Jul 05

It is now the norm for clinical and medical departments to work with a mixture of headcount, freelance and contract employees as well as outsourcing whole projects and there is no indication that going into 2005 and beyond, that there will be any change in this trend.
i3 Pharma Resourcing

Renalase as a new target for the treatment of cardiovascular disease particularly amongst patient with end-stage renal disease

26 Jul 05

The antihypertensive market was valued at $31 billion in 2003. The kidney plays an important role in regulating blood pressure and the renal enzyme renin is a target for what is expected to be the next blockbuster class of anti-hypertensives. The report highlighted here identifies a further renal enzyme, renalase that may be another target for the treatment of hypertension.
LeadDiscovery

Improved assay technology for the evaluation of airway therapeutic activity or toxicology

21 Jul 05

Assaying therapeutic agents requires the availability of apparatus to dose experimental animals as well as to measure biological effect. Available dosing systems for inhalation agents are suboptimal generally causing stress to the animal as well as exposing the operator to potentially harmful agents. Texas based researchers have developed an improved system for the delivery of agents to the airway
LeadDiscovery

Viramidine (Valeant Pharmaceuticals), a ribavirin prodrug for the improved treatment of hepatitis C (HCV) infection

18 Jul 05

Hepatitis C virus (HCV) infection produces cirrhosis, end-stage liver disease and liver cancer and by 2010 38,000 deaths will result from infection. Anemia associated with ribavirin, a common treatment of infected patients represents a major problem. Valeant Pharmaceutical have developed a prodrug of ribavirin, viramidine which is activated within the liver resulting in reduced levels of ribavirin accumulating in red blood cells thus overcoming the problem of anemia.
LeadDiscovery

Novel non-hydroxamic histone deactylase (HDAC) inhibitors in development from Miikana

14 Jul 05

The field of histone deacetylase inhibitors is moving into a new phase of development with candidates advancing nicely through clinical development. Milkana hasve recently developed a series of non-hydroxamic histone deactylase inhibitors which are likely to demonstrate an improved toxcity profile
LeadDiscovery

The mGlu5 receptor: a target for antagonists with improved anxiolytic activity

13 Jul 05

Anxiety disorders affect 20% of the total population across the seven major markets. Recent data demonstrates the efficacy of MPEP, the prototypical mGlu5 receptor antagonist as a an anxiolytic. Efficacy was similar compared to that of diazepam but at anxiolytic doses produces less cognitive decline
LeadDiscovery

DailyUpdates: Breaking Journal Articles & Press Releases for the Drug Development Sector

08 Jul 05

DailyUpdates was developed in 2002 by the drug development consultants, LeadDiscovery. Developed for the R&D community, 1,000's of individuals plus many of the top 20 pharmaceutical companies now use this simple yet effective tool to track key events in the drug discovery sector.
LeadDiscovery

Histone deacetylase inhibitors

06 Jul 05

The field of histone deacetylase inhibitors is moving into a new phase of development. The exponential growth in the level of research activity surrounding the histone deacetylases (HDACs) witnessed over the past decade has now started to produce success in the clinic, particularly in the field of oncology. Over the next few years experts believe that as first generation HDAC inhibitors produce clinical benefits and second generation inhibitors are rationally designed with improved specificity
LeadDiscovery

Aurora Kinase inhibitors

01 Jul 05

Cell cycle inhibitors represent a key approach to the treatment of cancer. Therapeutic agents have traditionally targeted early stages of the cell cycle (ie the G1/S phase checkpoint or the S phase) or mitotic spindle formation as exemplified by the alkaloids. Recently a new approach to cell cycle regulation has emerged with the identification of the Aurora kinase family. This report evaluates this exciting area of drug discovery
LeadDiscovery

TherapeuticAdvance-June 2005

29 Jun 05

Welcome to the June edition of TherapeuticAdvances, LeadDiscovery's free newsletter for the drug development sector. Read on for editorial comment on selected studies recently featured on DailyUpdates our regular bulletin of breaking journal articles and drug development news
LeadDiscovery

Chronic viral hepatitis: B is for billions

28 Jun 05

Despite recent advances in the treatment and management of hepatitis B, the market is still relatively immature, with several key unmet needs. Current pipeline products are expected to account for 89% of total market sales by 2015, however other developmental antivirals are also expected to contribute significantly to future market growth, potentially resulting in new treatment paradigms.
Datamonitor

Diabetes

17 Jun 05

The ancient Egyptians thought that diabetes was due to an ‘imbalance of the four bodily elements’ and that the best treatment to give these patients was a mixture of ground earth, water, wheat and lead. Thankfully, things have improved a little since then! In fact, the most important advance in diabetes management occurred in 1921 when the young surgeon Frederick Banting and the even younger medical student, Charles Best, first isolated insulin.
CSF Medical

Migraine

08 Jun 05

Fewer than 10% of people state that they have never had a headache.1 A recent UK survey identified 7.6% of males and 18.3% of females with migraine within the preceding year.2 Prevalence of migraine was shown to vary with age, rising through early adult life and declining in the late 40s and early 50s. Migraineurs reported at least one migraine attack per month on average, and most experienced interference with daily activities in at least 50% of their attacks.
CSF Medical Communications

Bipolar Disorder

31 May 05

Next to schizophrenia, bipolar disorder is the most important condition for psychiatrists to recognise and treat. Indeed, the discovery by John Cade in 1949 of lithium as an effective treatment for mania,1 and the finding in 1952 of chlorpromazine as an effective agent for acute psychotic states including mania, heralded the beginning of the modern era of psychopharmacology.
CSF Medical Communications

Schizophrenia

31 May 05

Schizophrenia can affect anyone, and is one of the greatest causes of lost quality of life worldwide. One-in-100 people will experience this serious mental illness at some time in their lives, though it commonly starts in the late teens to the early 20s in men and early to late 20s in women. Although schizophrenia can have a profound effect, it can be treated effectively in most people. This was not always the case.
CSF Medical Communications

Allergic Rhinitis

31 May 05

Allergic rhinitis is an increasingly prevalent disorder, affecting up to 40% of children and up to 30% of adults in the UK. The disease has traditionally been considered as either seasonal or perennial depending on the allergenic triggers and their presence in the environment. Typically, tree pollen promotes seasonal symptoms between February and April, grass pollens in late May through to early August, whilst weed pollens and mould spores are common in late summer and early autumn.
CSF Medical Communications

Hepatitis A/Typhoid Fever

31 May 05

Although difficult to determine accurately, annual global figures for reported cases of hepatitis A and typhoid are estimated to be in the region of 1.5 million and at least 16 million, respectively. Moreover, typhoid fever accounts for up to 600,000 deaths worldwide each year. The two diseases are often found in partnership and have common routes of transmission, particularly where sanitation is poor.
CSF Medical Communications

Will once-daily Kaletra be enough to see off the threat of Reyataz?

20 May 05

In addition to the traditional clinical needs, such as efficacy and resistance profile, product characteristics such as dosing and side effects can be fundamental in maintaining market share in the maturing antiretroviral market. In response to the launch of two once-daily protease inhibitors (PI), Abbott has reformulated its leading PI drug, Kaletra (lopinavir/ritonavir) in a once-daily dose.
Datamonitor

NHS pharmaceutical messaging service

11 May 05

New on-line system for hospital pharmacies makes ordering medicines easier, quicker and, being paperless, virtually error-free.
Mike Wood

Reduce costs & increase efficiency with SMS

11 May 05

Did you know you can generate SMS messages from any software that can send an email or generate an HTTP request such as Outlook, Lotus Notes..?
Mike Wood

Addressing the crisis facing the Clinical Research Staffing market

29 Apr 05

The Healthcare Industry is currently experiencing the effects of a global shortage of qualified and experienced clinical research professionals – and this situation has evolved into the industry’s very own version of ‘Catch 22’. While employers are looking to hire candidates who are already experienced in the practice of clinical research, new Life Science graduates and others wishing to start on a career in the Healthcare Industry are unable to gain such experience without first being hired.
Kieran Engels
European Director CRAcademy

Efficacy and improved tolerability of Hypericum perforatum extract, WS 5570, compared to paroxetine in patients with moderate to severe depression

16 Mar 05

Depression is the most common mental disorder worldwide affecting around 120 million people globally. The depression market is the largest segment of the CNS market with global sales of US$15.5 billion in 2003 although this figure is dropping as generic equivalents of past blockbusters are launched. Although the depression market has matured, key areas of unmet clinical need will have to be addressed in order to drive further growth of the market. These include improvements in the safety/tolerab
LeadDiscovery

Valeant Pharmaceuticals' remofovir mesylate, an improved adefovir prodrug for targeted and tolerable treatment of hepatitis B (HBV) infection

16 Mar 05

According to the WHO, 350-400 million individuals are chronically infected with the hepatitis B virus (HBV). Chronic infection with hepatitis viruses causes cirrhosis and hepatocellular carcinoma, both devastating diseases with few treatments and the demand for effective treatments for hepatitis infection is therefore high. Lamivudine dominates first-line therapy for HBV (see our feature on hepatitis B & C). Gilead's Adefovir prodrug (Hepsera) represent a second line option although nephrotoxici
LeadDiscovery

Long term beta adrenergic receptor blockade following myocardial infarction promotes myocardial angiogenesis

16 Mar 05

Beta blockers reduce heart rate and myocardial contractility thereby reducing myocardial work load. Diastolic perfusion time is also lengthened by beta blockers supporting the use of this drug class as acute and chronic treatment following myocardial infarction. Studies have demonstrated that beta blockers can reduce total mortality, nonfatal myocardial infarction and sudden death in patients who have already suffered a myocardial infarction by 20-30%. Despite the potential benefit of beta block
LeadDiscovery

Eisai's retinoic acid (RAR)-alpha receptor agonist as a candidate therapy for the treatment of lupus nephritis

16 Mar 05

Lupus is a chronic inflammatory disease that can affect various parts of the body, especially the skin, joints, blood, and kidneys. For most people, lupus is a mild disease affecting only a few organs. For others, it may cause serious and even life-threatening problems. In particular lupus nephritis claim a significant number of lives. More than 16,000 Americans develop lupus each year. It is estimated that 500,000 to 1.5 million Americans have been diagnosed with lupus. Current treatments focus
LeadDiscovery

The Best of Both Worlds

08 Mar 05

Imagine the benefits of working for a global organisation which turns over over £4 billion per year worldwide but is primarily family owned and complete with family values? This is exactly what Merck offers.
Pharmaceutical Field

Bipolar Disorder

03 Mar 05

Bipolar affective disorder – previously referred to as manic depression – is a psychiatric disorder affecting at least 1% of the UK population, and depending on the definition used, may affect as many as 5% of the population. A recent World Health Organization analysis of the major global causes of disability, economic and social burden, indicated that bipolar affective disorders are ranked in the top ten, and account for 2.5% of total years lost to disability across all age groups.
CSF Medical Communications

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