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Viramidine (Valeant Pharmaceuticals), a ribavirin prodrug for the improved treatment of hepatitis C (HCV) infection

18 Jul 05

Hepatitis C virus (HCV) infection produces cirrhosis, end-stage liver disease and liver cancer and by 2010 38,000 deaths will result from infection. Anemia associated with ribavirin, a common treatment of infected patients represents a major problem. Valeant Pharmaceutical have developed a prodrug of ribavirin, viramidine which is activated within the liver resulting in reduced levels of ribavirin accumulating in red blood cells thus overcoming the problem of anemia.
LeadDiscovery

Clinical Research a booming career - Are you ready for it?

18 Jul 05

Clinical Research is about rules and regulations and when one is aware of these rules and regulations then this facilitates working in this field.
Dr Dipti Sawant

Discover State of the Art Stem Cell Research in Europe

17 Jul 05

Two events are taking place that highlight the state of the art research that is currently being performed with stem cells in the Europe.
Dr Shara Cohen

A New Way to Access Information for Life Scientists

17 Jul 05

Euroscicon, a new meetings organisation company in London has plugged the gap in scientific education, with a novel approach to scientific meetings. Meetings include hot areas of research such as stem cells, microarrays, live cell imaging and proteomics both mirror current scientific emphasis and set the tone for future advances.
Dr Shara Cohen

Capravirine discontinued, but Pfizer's HIV R&D won't stop

15 Jul 05

Pfizer has announced that it is to discontinue the development of its pipeline HIV drug capravirine, after phase II studies highlighted limited efficacy and tolerability issues compared to other products. However, Pfizer has another, and perhaps more impressive, trick up its sleeve, namely its promising CCR5 inhibitor maraviroc.
Datamonitor

Novel non-hydroxamic histone deactylase (HDAC) inhibitors in development from Miikana

14 Jul 05

The field of histone deacetylase inhibitors is moving into a new phase of development with candidates advancing nicely through clinical development. Milkana hasve recently developed a series of non-hydroxamic histone deactylase inhibitors which are likely to demonstrate an improved toxcity profile
LeadDiscovery

The mGlu5 receptor: a target for antagonists with improved anxiolytic activity

13 Jul 05

Anxiety disorders affect 20% of the total population across the seven major markets. Recent data demonstrates the efficacy of MPEP, the prototypical mGlu5 receptor antagonist as a an anxiolytic. Efficacy was similar compared to that of diazepam but at anxiolytic doses produces less cognitive decline
LeadDiscovery

Daxas deal leaves Altana short of breath

08 Jul 05

Altana and Pfizer have terminated an agreement to develop the respiratory disease drug Daxas following unimpressive phase III results. Altana will continue Daxas' development, but additional trials may be required. Pfizer, meanwhile, will focus efforts on an alternative in-house compound, with an eye on developing a dual-action COPD product.
Datamonitor

DailyUpdates: Breaking Journal Articles & Press Releases for the Drug Development Sector

08 Jul 05

DailyUpdates was developed in 2002 by the drug development consultants, LeadDiscovery. Developed for the R&D community, 1,000's of individuals plus many of the top 20 pharmaceutical companies now use this simple yet effective tool to track key events in the drug discovery sector.
LeadDiscovery

Histone deacetylase inhibitors

06 Jul 05

The field of histone deacetylase inhibitors is moving into a new phase of development. The exponential growth in the level of research activity surrounding the histone deacetylases (HDACs) witnessed over the past decade has now started to produce success in the clinic, particularly in the field of oncology. Over the next few years experts believe that as first generation HDAC inhibitors produce clinical benefits and second generation inhibitors are rationally designed with improved specificity
LeadDiscovery

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