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1268 Features
Merckle demonstrate superior safety of Licofelone the first dual COX/LOX inhibitor: Opportunities for improved osteoarthritis treatment

22 Apr 04

DailyUpdates 22nd April: Phase III studies have previously shown Merkle’s first in the class COX/LOX inhibitor, Licofelone, to be equally effective to standard treatments of osteoarthritis. Moreover, gastrointestinal adverse events tended to be less frequent in patients treated with licofelone as compared to naproxen. In this month’s edition of the American Journal of Gastroenterology new data is published showing clear cut advantages of licofelone arising from the dramatic reduction in incide

HU-320 identified as a novel synthetic cannabinoid with therapeutic activity in an experiment model of rheumatoid arthritis

20 Apr 04

DailyUpdates 20th April: An estimated 5 million individuals suffer from rheumatoid arthritis in the Western world. CB1 cannabinoid receptor ligands are in development as candidate treatments of this disease due to their analgesic properties. Now researchers from the Hebrew University and the Kennedy Institute of Rheumatology in London have demonstrated the anti-inflammatory, disease modifying efficacy of the non-psychoactive cannabinoid, HU-320 in a model of rheumatoid arthritis.

NicOx's nitrosulindac (NCX 1102) emerges as a candidate treatment of bladder cancer

19 Apr 04

DailyUpdates 19th April: NSAIDs have shown promising activity in the prevention and possible treatment of cancer. The French pharmaceutical NicOx has successfully improved both the safety and efficacy of NSAIDs by attaching a nitric oxide donor group to various NSAIDs. In a recent study nitrosulindac has been demonstrated to act as an effective and selective cytotoxic and antiproliferative agent against bladder cancer cells. The efficacy of nitrosulindac was considerable better than sulindac.

Gene silence to set to quieten neuropathic pain - Novartis research expands the potential of siRNA

16 Apr 04

DailyUpdates 16th April: RNA interference is emerging as a major tool to help researchers identify new therapeutic targets. Novartis researchers have recently used this technology to underline the role that the ligand activated cation-channel, P2X3 plays in neuropathic pain. This study also demonstrates the therapeutic potential of P2X3 gene silencing in the treatment of this major unmet area of analgesia.

Prodrugs: Effective Solutions for Solubility, Permeability, and Targeting Challenges

16 Apr 04

Pharmaceutical Education Associates is proud to present: The Inaugural Prodrugs: Effective Solutions for Solubility, Permeability, and Targeting Challenges Conference, June 28-29, 2004 at The Union League, Philadelphia, PA. . Please visit for more details, or call 800-686-2276.
Jennifer McGinnis

Paclitexel-induced neuropathic pain - McGill study may lead to the identification of novel targets for analgesia and improved cancer therapeutics

14 Apr 04

DailyUpdates 14th April: Neuropathic pain affects 26 million patients including a sub-population of cancer patients being treated with cytotoxics. McGill researchers have published the results of a study looking at neuropathic pain in various strains of mice. These data show that neuropathic pain has a genetic component suggested to be equally relevant to paclitaxel and surgically-induced pain. The study also advances the use of paclitaxel-induced hyperalgesia as a model for the development o

Novo Nordisk publish data demonstrating proof of concept for potassium channel openers as treatments of diabetes

13 Apr 04

DailyUpdates 13th April: According to WHO, there are some 130 million diagnosed diabetics in the world, a figure that is predicted to increase to 300 million by 2025. Approximately 10-15% of these patients suffer type 1 diabetes. Novo Nordisk have shown that their Kir6.2/SUR1 channel opener, NN414 is able to preserve beta-cell function and reduction of insulitis presumable through the induction of "beta-cell rest".

Drug delivery technology predicted to allow safer and more effective use of steroids in the treatment of rheumatoid arthritis

08 Apr 04

DailyUpdates 8th April: An estimated 5 million individuals suffer from rheumatoid arthritis in the Western world. Corticosteroids are the most dramatically effective short-term anti-inflammatory drugs; however, their clinical benefit for rheumatoid arthritis often diminishes with time. This, the severe rebounds observed following the withdrawal of corticosteroids, and long-term systemic side effects associated with corticosteroids limits their use in the treatment of rheumatoid arthritis. Rese

Eli Lilly's Duloxetine set to become the first widely used therapeutic treatment of stress urinary incontinence

07 Apr 04

DailyUpdates 7th April: A recent survey of community-dwelling women in France, Germany, Spain and the UK found that 35% women suffer urinary incontinence, the most prevalent form of which was stress urinary incontinence. The findings also revealed that two-thirds of women affected with urinary incontinence never consulted a health care professional for treatment. The perceived and real lack of pharmaceutical options for the treatment of stress urinary incontinence is a major factor contributing

New data shows that intensive treatment of diabetes may lower coexistent hypertension and delay renal dialysis by up to 20 years

06 Apr 04

DailyUpdates 6th April: According to WHO, there are some 130 million diagnosed diabetics in the world and the long term consequences of diabetes such as diabetic nephropathy are becoming increasingly frequent and unmet components of diabetes care. In a recent study Glasgow Royal Infirmary researchers report that intensive treatment slowed progression of renal disease within 2 years in patients with established diabetic nephropathy and predict that this approach may delay the onset of dialysis b

Links between obesity/diabetes & Alzheimer disease: Diet-induced insulin resistance shown to increase CNS beta-amyloid levels and worsens cognition in a model of Alzheimer disease

05 Apr 04

DailyUpdates 5th April: There is growing evidence of a link between type-2 diabetes/obesity and Alzheimer disease. Researchers now report that diet-induced insulin resistance increases beta amyloid generation, amyloid plaque burden in the brain and behavioural impairment in a model of Alzheimer disease.

Type 2 diabetes as a risk factor for Alzheimer's disease - defective insulin-degrading enzyme as an etiological link?

02 Apr 04

DailyUpdates 2nd April: There is growing evidence that type-2 diabetes is a risk factor for Alzheimer disease. In their April American Journal of Pathology article Brigham and Women's Hospital researchers add further evidence to support defects in insulin-degrading enzyme activity as a potential cause of this phenomenon. This and similar data argues for the development of cross-indication treatments of type-2 diabetes and Alzheimer disease and GSK-3 inhibitors may fit the bill.

GREES publish new recommendations on the clinical development of disease modifying osteoarthritis drugs (DMOADs)

01 Apr 04

DailyUpdates 1st April: Osteoarthritis is the most common form of arthritis and is estimated to affect over 73 million people in the seven major pharmaceutical markets. Disease modifying osteoarthritis drugs (DMOADs) currently represent the ‘holy grail’ in the treatment of osteoarthritis. The Group for the Respect of Ethics and Excellence in Science (GREES) have now published recommendations on the clinical development of DMOADs.

Merck & Co develop new leads for the treatment of bipolar disorder through the development of a new HTS assay of inositol monophosphatase inhibitors

31 Mar 04

DailyUpdates 31st March: Bipolar disorder affects over 2 million people in the US alone. Lithium, which inhibits inositol monophosphatase, has long been a first line mood stabilizer used in the treatment of this condition. Merck & Co have now developed a new cell-based HTS assay to identify novel inositol monophosphatase inhibitors which will hopefully lead to improved treatments of bipolar disorder.

Sulfonylureas vs thiazolidinediones for the prevention of diabetic nephropathy

30 Mar 04

DailyUpdates 30th March: According to WHO, there are some 130 million diagnosed diabetics in the world and the long term consequences of diabetes such as diabetic nephropathy are becoming increasingly frequent and unmet components of diabetes care. Intensive glycemic control prevents or retards microalbuminuria, an early sign of nephropathy in patients with type 2 diabetes and in a recent study Japanese researchers compare two different classes of oral antidiabetic drugs with respect to their e

New data published on KW-7158, a novel treatment of overactive bladder

29 Mar 04

Overactive bladder, a condition associated with a variety of other pathologies affects over 17 million Americans and costs the US over $12 billion per year. Current treatments focus on the muscarinic receptor antagonists such as tolterodine and oxybutanin with further examples from this class expected on the market. Therapeutics from novel pharmacological classes are expected to offer further improvements and in an upcoming edition of the Journal of Pharmacology & Experimental Therapeutics Uni

Naked Ambition

28 Mar 04

The presence of Arthur Dent's in pyjamas throughout the Hitch Hiker's Guide to the Galaxy, in a series of increasingly surreal encounters, acts as a constant reminder to the reader that no matter what
Daniel Judge

All in the name of research

25 Mar 04

Andrew Curl from the ABPI explains more about the industry's ability to innovate and provide world-beating medicines.
Claire Richland

Finding the Next Asian Pharma Sensation

19 Mar 04

Japan has always been considered the technology pioneer of Asia, however, in recent years a number of other countries in this region have placed significant emphasis on industrial and technological performance in order to improve their own world position. One industry that is developing rapidly in the region is the pharmaceutical industry.
Dr Faiz Kermani and Dr Rebecca Gittins

Emerging Drug Discovery Targets: 6th February

13 Feb 04

This edition of "Emerging Drug Discovery Targets" features a potential approach to the treatment of COPD; Ligands' retinoic acid receptor agonist with appetite suppressive and insulin sensitizing properties; the use of HDAC inhibitors for the treatment of rheumatoid arthritis; Tamoxifen as a dual chemopreventative and anti-atherosclerosis treatment; and broad based inhibition of multidrug resistance proteins for improved cancer treatment. As usual we also provide updates on industrial advances a

Pharma NewsBytes: 6th February

13 Feb 04

Pharma NewsBytes selects out what we consider as being some of the most interesting press releases to have appeared on our DailyUpdates tracking service over the past few weeks. Currently featured new items focus on a number of novel approaches to the treatment of cancer including the development of caspase inhibitors; gene therapy approaches to the expression of TNF-alpha; an advanced monoclonal antibody; and a strategy to block XIAP. In addition new therapeutics for the treatment of rheumatoid

The effects of insulin on airway function: repercussions for intra-tracheal insulin delivery and for asthma therapeutics

13 Feb 04

According to WHO, there are some 130 million diagnosed diabetics in the world. The market for diabetes therapeutics is rising. Oral antidiabetic drugs, the leading class of drugs used to treat the disease, accounted for almost 63% of sales during this period, while sales of insulin stand at around 30%. Further increases are inevitable and the market for diabetes medications could exceed $20 billion by 2006. The largest unmet need in the diabetes market is improved delivery of insulin. Currently,

Canada commits to R&D

04 Feb 04

By 2010 Canada aims to become one of the top 5 countries in the world in terms of industrial R&D performance. Its pharmaceutical and biotech sectors, which are already key contributors to the economy, look set to prosper.
Dr Faiz Kermani and Dr Rebecca Gittins

Emerging Molecular Targets to Treat Disorders Affecting Cognitive Function

03 Feb 04

Pharmaceutical Education Associates’ presents a one-of-a-kind forum exploring the most recent and clinically relevant research pertaining to brain targets for the enhancement of cognitive function. Of particular interest will be the effectiveness of new cognition-enhancing drugs in the treatment of neurodegenerative disorders such as Alzheimer’s disease, as well as their potential for the treatment of the cognitive decline associated with normal aging or as a prelude to disease.
Jennifer McGinnis


20 Jan 04

a Bristol based Biochemical Company, says it has invented a new sprayable antibacterial disinfectant agent, to be launched under the name of D-Stroy, that can kill the hospital superbug MRSA and TB.
Daisy Norman

Why Pharmaceutical R&D investment can pay off

19 Jan 04

Obtaining a benefit from pharmaceutical R&D investment requires long-term planning and a consideration of how the commercial and technological environment in which the industry operates might change.
Dr Faiz Kermani

Can Pharma Reign in Spain? – Part 2

12 Jan 04

Spain has a buoyant pharmaceutical market, but it is also a growing centre for pharmaceutical R&D. Industry figures show that there has been a rapid rise in R&D investment in the country since the early 1990s.
Dr Faiz Kermani

Emerging Drug Discovery Targets (18th December 2003)

05 Jan 04

This edition of features new generation oncolytic viruses from Cell Genesys active against colorectal cancer cells; a p38 MAPK inhibitor for the treatment of rheumatoid arthritis from Fujisawa; data describing the anti-angiogenic activity of bisphosphonates in cancer models; a new JAK3 inhibitor from Pfizer for transplant rejection; and an integrin antagonist from Merck for the treatment of osteoporosis. As usual updates on industrial advances and licensing opportunities are provided.

2nd Annual Pediatric Drug Development

02 Jan 04

Pharmaceutical Education Associates' proud to present our 2nd Annual Pediatric Drug Development conference, slated for February 23-24, 2004 in Washington, D.C. Don't miss your chance to hear about the key issues impacting pediatric drug development today! For more information call us at 800-686-2276 visit
Feliz Casanova

Can Pharma Reign in Spain? – Part 3

23 Dec 03

The growth of the pharmaceutical market and an improvement in the conditions for R&D, have led to increased emphasis being placed on Spain by pharmaceutical companies. Measures have also been taken by the Spanish government to directly boost pharmaceutical R&D innovation.
Dr Faiz Kermani

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