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Feature

Speed up Pharmaceutical Compounds Synthesis

Synthesis chemistry Posted on: 19 Dec 16
Speed up Pharmaceutical Compounds Synthesis

Summary

Pharmaceutical compounds synthesis can be speed up by a new technology.

Chemical synthesis is commonly employed in compound preparation, especially for pharmaceutical applications. The appearance of synthesis chemistry helps to save cost both for researchers and practical usages. Take pharmaceutical field alone for example, medicine prices are greatly decreased since synthesis chemistry is widely applied. A recent advance in the field will furtherly boost the efficiency of synthesis while make it cheaper.



Two young researchers from Indiana University-Purdue University Indianapolis (IUPUI) developed a new synthesis method for nitrogen-based compound to shorten the general time involved in the related projects. Meanwhile, the budget for such synthesis is decreased with the optimization in involved ingredients, which is a perfect example of-one stone with two birds. They published the paper on Nature Chemistry in the title of Site-selective C–H arylation of primary aliphatic amines enabled by a catalytic transient directing group.



The new synthesis tech is a hydrocarbon transformation and molecule binding method under the assistance of transition-metal-catalyze. It’s of note that C-H bond changes in compounds directly lead to huge difference in their fictionalizations thus the new synthesis technology is of great potential in pharmaceutical applications and may also bring more possibilities for new types of energy source.



What makes the approach more significant is that it’s highly site-selective and the involved transition-metal-catalyze-glyoxylic acid is cheap and with easy access. Besides, with no special requirements on the protective conditions, a wide array of γ-arylated primary alkylamines were produced, fewer special reaction conditions meaning less cost. With the background, the tech can lead to direct preparation of some designed compounds. The team has successfully synthesized fingolimod, which proved the feasibility of the new method.



Site-selective carbohydrate transformation has been studied for over a century but no effective and economic ways were found until this year by the two young researchers- Haibo Ge and Yongbing Liu. The tech will facilitate drug discovery process in providing more possibilities while being cost-effective. Also it will boost the drug price goes to a cheaper level as about 75% of pharmaceuticals are synthesized and can benefit from this progress. Chemical synthesis service will undoubtedly be leveled up to a brand new state.



Author Bio

BOC Sciences is a leading supplier of chemicals and professional services regarding pharmaceutical, biotechnological and agricultural research and development. Chemical synthesis is one of the featured services the company provides, covering carbohydrate synthesis service, enzyme synthesis service. With the advancement of synthesis, the whole industry will be improved, as well as other industries like green energy.


Linna Green

Last updated on: 19/12/2016 02:12:05

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