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Press Release

Bend Research Receives Two U.S. Patents for Technology to Enhance the Bioavailability of Low-Solubility Drugs

Bend Research Inc.
Posted on: 11 Oct 12

Bend Research Inc. (, a leading independent drug-formulation development and manufacturing company, announced that it has received two new U.S. patents related to its pioneering efforts to improve the oral bioavailability of low-solubility drugs.

The patents protect compositions and processes for making spray-dried dispersions (SDDs) that enhance the absorption of low-solubility drugs. The patents cover SDDs made with an active pharmaceutical ingredient (API) and hydroxypropyl methylcellulose acetate succinate (HPMCAS), a polymer that is also known as hypromellose acetate succinate.

Demand is high for this technology, since more than 40% of drugs in development are estimated to have low aqueous solubility. The HPMCAS SDDs enable the use of lower drug doses to achieve effective therapies for low-solubility drugs. The technology works by sustaining high concentrations of drug in patients’ gastrointestinal tracts.

“These patents offer important protection for this vital technology,” said Bend Research CEO Rod Ray. “Our goal is to provide a growing patent portfolio for our customers’ use in protecting their investments in advancing low-solubility compounds to the market.”

The patents are among a growing number of formulation- and process-related patents associated with Bend Research’s solubility-enhancing drug-formulation technologies. These solubilization technologies enhance the concentration of drug in patients’ bloodstreams and enable faster drug dissolution than is possible with crystalline drug forms.

The patents, which are both titled “Solid Pharmaceutical Dispersions with Enhanced Bioavailability,” were assigned Patent Nos. 8,257,741 and 8,263,128 by the U.S. Patent and Trademark Office. The inventors are William Curatolo, Scott Herbig, and Jim Nightingale. Both patents are the result of work funded by Pfizer Inc. and are assigned to Bend Research Inc.

About Bend Research Inc.

For more than 35 years, Bend Research has worked with clients to create value by advancing new medicines that improve human health and by solving their most difficult scientific and technical problems. This success is based on the company’s ability to develop, advance, and commercialize pharmaceutical technologies, which grow from a solid base of scientific and engineering fundamental understanding.

Bend Research capabilities include formulation and dosage-form support, process development and optimization, manufacture of clinical-trial quantities of drug candidates in its cGMP facilities, and advancement of promising drug candidates from conception through commercialization.Bend Research is a leader in novel formulations, including SDDs and hot-melt extrusions, and controlled-release, inhalation, and biotherapeutics technologies.

Bend Research has more than 300 employees based in six state-of-the-art facilities in Bend, Ore., USA.

Business Wire

Last updated on: 11/10/2012

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