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Features
Peripheral Arterial Disease Represents a Significant and Rapidly Growing Market Opportunity for Interventional Therapies, Particularly Endovascular Technologies

26 Aug 04

ATLANTA--Aug. 25, 2004--Endovascular intervention, employing minimally invasive, catheter-based technologies, is expected to become the dominant therapeutic modality for atherosclerotic diseases in the lower limbs, according to a new report published by THE SAGE GROUP
LeadDiscovery

Clinical data further demonstrates the efficacy of Pfizer's pregabalin (Lyrica) in the treatment of diabetic neuropathic pain

25 Aug 04

DailyUpdates 25th August, 2004: Despite legal appeals by Pfizer, Ivax's generic equivalent of the blockbuster gabapentin (Neurontin) went on sale earlier this month increasing the need for Pfizer to push the follow-on, pregabalin onto the US market. Pregabalin was approved by European authorities in July of this year for the treatment of peripheral neuropathic pain and as an adjunctive therapy for partial seizures in patients with epilepsy. Most recently a US study has been published data furthe
LeadDiscovery

Low level carbon monoxide exposure as a therapeutic approach to improving transplant outcome

24 Aug 04

DailyUpdates 24th August, 2004: Heme oxygenase-1 (HO-1), one of the enzymes responsible for the production of carbon monoxide, is induced under conditions of ischemic stress. Clinical data has previously demonstrated that increased expression of HO-1 may limit post-transplant ischemia reperfusion injury, a major cause of reduced graft survival. Now researchers have reported that maintaining transplant recipients in an atmosphere of elevated carbon monoxide promotes extended graft survival
LeadDiscovery

Clinical data supports the development of insulin as a future treatment for memory and mood disorders?

23 Aug 04

DailyUpdates 23rd August, 2004: The use of insulin forms the cornerstone of diabetes treatment. A body of data also suggests however that this hormone directly modulates both memory and mood suggesting that endogenous insulin may be of benefit to many of the 180 million people around the world with memory disorders, and especially those with co-morbid mood disturbances such as schizophrenic or depressed individuals. A recent study has shown that intra-nasal administration of insulin improves m
LeadDiscovery

WILL YOUR METHOD SURVIVE BEYOND YOUR LAB?

23 Aug 04

Eventually, methods developed by research laboratories need to be transferable to face the rigours of external validation or the production line. Many researchers, however, are unaware that this procedure must be adequately documented, a crucial issue when it comes to regulation and outsourcing.
Rachel Holdsworth/Geoff Pulham

It's not just drug discovery that's an expensive business

23 Aug 04

Pharmaceutical practices from manufacturing to marketing are coming under increasing scrutiny from watchdogs, regulators and shareholders. As huge fines and record settlements erode profits, Datamonitor's Andrew Jones argues that pharma companies must focus on tightening compliance...
Datamonitor

Singapore strives for success

22 Aug 04

As the pharmaceutical industry expands its global outlook, many companies have taken a greater interest in the region of South-East Asia. The emergence of this area as a centre for R&D activities is typified by Singapore, which has made a strong commitment to raising its profile and attracting major companies.
Dr Faiz Kermani

Researchers report on the role of estrogen in airway function: Can menopause accelerate the progression of COPD?

19 Aug 04

DailyUpdates 18th August, 2004: Recent data suggest that women may be more susceptible to the chronic airway disorders emphysema and bronchitis, together known as chronic obstructive pulmonary disease (COPD). The reasons for this are unclear however data published this month demonstrate a key role of the estrogen receptor in maintaining alveolar surface area and airway elasticity. This suggests that menopause may contribute to the acceleration of COPD and prompts investigation into the develop
LeadDiscovery

Can you Sell Yourself?

18 Aug 04

After my many years of conducting interviews and recruiting for both junior and senior employees, I have come to the conclusion that if there is one single thing that a person can do to secure a second interview or a desired position it is believe in themselves.
Susan Mason

Proteolytic beta amyloid light chain antibody fragments offer promise as future treatments of Alzheimer’s disease.

17 Aug 04

DailyUpdates 18th August, 2004: Researchers from at Arizona State University have demonstrated that beta amyloid light chain proteolytic antibody fragments can cleave beta-amyloid, altering the aggregation and neutralizing the cytotoxic effects of this peptide.
LeadDiscovery

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