Pharmiweb ChannelsAll | PharmaCo | Clinical Research | R&D/BioTech | Sales/Mktg | Healthcare | Recruitment | Pharmacy | Medical Comms

Pharmiweb.com RSS Feed Pharmiweb.com RSS Feeds

Advertising

Press Release

Poseida Awarded $19.8 Million CIRM Grant to Support Clinical Trial of P-BCMA-101, a T Stem Cell Memory CAR-T Therapy for Multiple Myeloma


Posted on: 26 Oct 17

SAN DIEGO, Oct. 26, 2017 (GLOBE NEWSWIRE) -- Poseida Therapeutics Inc. (“Poseida”), a San Diego-based company translating best-in-class gene therapy technologies into lifesaving cell therapies, today announced that the California Institute for Regenerative Medicine (CIRM) awarded a $19.8 million grant to support the clinical development of Poseida’s P-BCMA-101 product candidate. P-BCMA-101 is a chimeric antigen receptor T cell (CAR-T) immunotherapy currently in a Phase 1 clinical trial as a treatment for relapsed and refractory multiple myeloma.

“We are honored that CIRM has recognized the promise of P-BCMA-101 as an immunotherapy for patients with multiple myeloma and is contributing to the advancement of this program in Phase 1 clinical development,” said Eric Ostertag, M.D., Ph.D., chief executive officer of Poseida. “P-BCMA-101 is elegantly designed with several key characteristics, including an exceptionally high concentration of stem cell memory T-cells which has the potential to significantly improve durability of response to treatment.”

The P-BMCA-101 product candidate is a CAR-T immunotherapy designed to supercharge a patient’s own T cells to safely and effectively eliminate tumor cells carrying B cell maturation antigen (BCMA), which is expressed on essentially all multiple myeloma cells. P-BCMA-101 modifies a patient’s T cells using a non-viral gene delivery system called piggyBac™, which enables several desirable features, including:

  • T stem cell memory: P-BCMA-101 is comprised of an exceptionally high proportion of stem cell memory T cells, resulting in unprecedented durability of response without re-administration of product in multiple preclinical studies.
  • Pure product: The addition of a human-derived positive selection gene results in a product that is essentially 100% pure in contrast with lentivirus-based products, which are generally 5-30% pure.
  • Safety: piggyBac™ has safer integration profile than lentivirus and is non-oncogenic. In addition, a human-derived safety switch is added such that P-BCMA-101 can be rapidly attenuated or eliminated if significant side effects occur.

“Poseida is developing a promising next generation CAR-T cell therapy which includes many of the desirable attributes of emerging CAR-T cell therapies into a single treatment,” said Maria Millan, M.D., President and CEO of CIRM. “CIRM is pleased to support Poseida in the development of this novel CAR-T therapy which represents a much-needed solution for multiple myeloma.”

Additional information about this Phase 1 clinical study of P-BCMA-101 is available at www.clinicaltrials.gov using identifier: NCT03288493

About Poseida Therapeutics Inc.
Poseida Therapeutics is translating best-in-class gene therapy technologies into lifesaving cell therapies. The company is developing CAR T-cell immunotherapies for cancer, as well as gene therapies for orphan diseases. P-BCMA-101 is Poseida’s lead CAR-T therapy currently in Phase 1 clinical development for the treatment of multiple myeloma. Poseida has assembled a suite of industry-leading gene therapy technologies, including the piggyBac™ DNA Modification System, XTN™ TALEN and NextGEN™ CRISPR site-specific nucleases, and Footprint-Free™ Gene Editing (FFGE).  For more information, visit www.poseida.com.

Corporate Communications Contact:
Jason Spark
Canale Communications
619-849-6005
Jason@canalecomm.com

GlobeNewswire
globenewswire.com

Last updated on: 27/10/2017

Advertising
Site Map | Privacy & Security | Cookies | Terms and Conditions

PharmiWeb.com is Europe's leading industry-sponsored portal for the Pharmaceutical sector, providing the latest jobs, news, features and events listings.
The information provided on PharmiWeb.com is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her physician.