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Endometriosis Market Spotlight Research Report 2017-2027 - Research and Markets

Research and Markets
Posted on: 09 Nov 17

The "Market Spotlight: Endometriosis" report has been added to Research and Markets' offering.

This Market Spotlight report covers the Endometriosis market, comprising key pipeline and marketed drugs, clinical trials, upcoming and regulatory events, patent information, a 10-year disease prevalence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.

Key Takeaways

  • The author estimates that in 2016, there were 186.9 million prevalent cases of endometriosis in women aged 15-49 years worldwide, and forecasts that number to increase to 196.6 million prevalent cases by 2025.
  • Endometriosis affects an estimated 1 in 10 women in the reproductive age group of 15-49 years.
  • The majority of industry-sponsored drugs in active clinical development for endometriosis are in Phase II. Therapies in mid- and late-stage development for endometriosis focus on targets such as the gonadotropin-releasing hormone (GnRH) receptor, progesterone receptor, and luteinizing hormone receptor. Among these therapies, Elagolix, a first-in-class GnRH receptor antagonist, is closest to market. All pipeline drugs in mid- and late-stage development for endometriosis are administered via the oral route.
  • Approved drugs in the endometriosis space target the GnRH receptor, progesterone receptor, follicle-stimulating hormone, and androgen receptors. The majority of marketed drugs are administered via the subcutaneous route, while oral and intramuscular formulations are also available.
  • The main high impact upcoming event in the endometriosis space is topline Phase III trial results for Relugolix. There were 11 licensing and asset acquisition activities involving endometriosis drugs during 2012-17. The largest deal was in 2017, when AstraZeneca obtained commercialization rights to Zoladex in the US and Canada from TerSera Therapeutics for $320m.
  • A composition patent for Lupron is set to expire in 2019, opening the door to generic entry. Lupron's sales ranked highest among drugs approved in the endometriosis space during 2012-16. Elagolix, which is estimated to be launched in 2018, is expected to achieve blockbuster sales by 2021.
  • The distribution of clinical trials across Phase I-IV indicates that the majority of drugs are in the early and mid-phases of development, with 76% of trials in Phase I-II, and only 24% in Phase III-IV.
  • The US has a substantial lead in the number of endometriosis clinical trials globally, yet forecasted prevalent cases of endometriosis are lower in North America as compared to Europe and Asia. Germany leads the major EU markets, while Japan has the top spot in Asia, where prevalent cases of endometriosis are highest.
  • Clinical trial activity in the endometriosis space is dominated by completed trials, with only 10% of trials currently ongoing. Bayer, Takeda, AbbVie, and Neurocrine Biosciences have the highest number of completed clinical trials for endometriosis.

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Last updated on: 09/11/2017

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