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Press Release

Global Drug Analysis: TetraVax-DV - A Potential Best-in-Class Live-Attenuated Vaccine -

Research and Markets
Posted on: 15 Feb 18

The "Drug Analysis: TetraVax-DV" drug pipelines has been added to's offering.

TetraVax-DV is a lyophilized, tetravalent, live-attenuated chimeric vaccine currently in Phase II/III development. The viral strains were formulated by the US National Institutes of Health (NIH) and have been licensed by vaccine producers in India (Biological E/Panacea Biotec), Brazil (Butantan Institute), and Vietnam (Vabiotech). Merck & Co has also in-licensed the vaccine from the NIH in order to investigate the potential of a heterologous prime-boost strategy with its own in-house vaccine, V180 (adjuvanted, tetravalent DEN-80E subunit vaccine).

TetraVax-DV has emerged as a potential best-in-class live-attenuated vaccine based on Phase I studies, which showed impressive rates of tetravalent seroconversion after a single dose of the TV-003 and TV-005 formulations. It is expected that the vaccine's low production costs and anticipated lower price compared to the other tetravalent live-attenuated chimeric vaccines, Dengvaxia (Sanofi Pasteur) and TAK-003 (Takeda), will allow local manufacturers to dominate their respective domestic markets. In addition, the Butantan Institute is expected to export TetraVax-DV to other endemic Latin American markets from Q2 2019, greatly reducing the commercial attractiveness of this region for other vaccines companies. Aside from dengue-endemic markets, TetraVax-DV's impressive immunogenicity in flavivirus-nave recipients and its attractive dosing schedule also position it as a strong candidate for travelers and/or the military.

Key Topics Covered:

Product Profiles

TetraVax-DV: Dengue vaccines

List of Figures

Figure 1: Design of the TetraVax-DV vaccine

Figure 2: TetraVax-DV for dengue fever - SWOT analysis

List of Tables

Table 1: TetraVax-DV drug profile

Table 2: TetraVax-DV completed studies in dengue fever

Table 3: TetraVax-DV ongoing studies in dengue fever

For more information about this drug pipelines report visit

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Business Wire

Last updated on: 15/02/2018

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