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Global Amyloidosis Market Spotlight 2017-2027 - ResearchAndMarkets.com

Research and Markets
Posted on: 16 Feb 18

The "Market Spotlight: Amyloidosis" report has been added to ResearchAndMarkets.com's offering.

This Market Spotlight report covers the amyloidosis market, comprising key pipeline and marketed drugs, upcoming and regulatory events, patent information, a 10-year disease prevalence forecast, and licensing and acquisition deals.

Key Takeaways

  • The author estimates that in 2016, there were approximately 59,000 incident cases of amyloidosis worldwide, with the highest proportion being the primary (amyloid light-chain; AL) amyloidosis type.
  • Among incident multiple myeloma cases, the author estimates there were approximately 14,600 cases of AL amyloidosis worldwide in 2016.
  • Vyndaqel (tafamidis meglumine) is the only US Food and Drug Administration (FDA)-approved drug for transthyretin (TTR)- related hereditary amyloidosis (familial amyloid polyneuropathy).
  • There are more industry-sponsored drugs in active clinical development for amyloidosis in Phase III than in any other phase. Therapies in development for amyloidosis focus on targets such as TTR, AL, cluster of differentiation (CD)38, proteasome, and serum amyloid P (SAP) component. The majority of therapies in development for amyloidosis are administered via the intravenous route, with the remainder being oral and subcutaneous formulations.
  • High-impact upcoming events for drugs in the amyloidosis space include topline Phase III trial results for patisiran. There were seven licensing and asset acquisition activities involving amyloidosis drugs during 2012-17. The largest deal during that time was the $1,135m exclusive worldwide licensing and development agreement (in August 2012) between Janssen Biotech and Genmab, for the development and commercialization of Genmab's daratumumab and a backup human CD38 antibody.
  • The clinical trials distribution across Phases I-IV indicates that the majority of trials for amyloidosis have been in early and midphases of development, with 80% of trials in Phase I-II and only 20% in Phase III-IV.
  • The US has a substantial lead in the number of amyloidosis clinical trials globally. The UK leads the major EU markets, while Japan has the top spot in Asia.
  • Clinical trial activity in the amyloidosis space is dominated by completed trials. GlaxoSmithKline has the highest number of completed clinical trials for amyloidosis, with four.
  • Pfizer has carried out the most Phase III trials in amyloidosis (with three), followed by Alnylam, which has sponsored one Phase III trial.

Key Topics Covered:

KEY TAKEAWAYS

DISEASE BACKGROUND

Amyloidosis subtypes

TREATMENT

Chemotherapy

Targeted therapy

Surgery

Bone marrow/stem cell transplantation

Palliative or supportive care

EPIDEMIOLOGY

Amyloidosis in multiple myeloma incidence methodology

MARKETED DRUGS

Approvals by country

PIPELINE DRUGS

KEY UPCOMING EVENTS

LICENSING AND ASSET ACQUISITION DEALS

GSK Passes On Taking Inotersen To FDA With Ionis

Fortress Subsidiary Licenses Amyloidosis Candidate From Columbia

PARENT PATENTS

CLINICAL TRIAL LANDSCAPE

Sponsors by status

Sponsors by phase

APOLLO Success Clears Alnylam For Lift-Off

Ionis Touts Inotersen's Convenience As Phase III Safety Data Disappoint

Alnylam Plays Up Patisiran As Polyneuropathy Drug Nears Filings

Alnylam Ends Revusiran In Phase III, But Was Failure Due To Safety Or Efficacy?

Ionis Antisense Platform Safety Questioned After Thrombocytopenia Seen In Studies

BIBLIOGRAPHY

APPENDIX

For more information about this report visit https://www.researchandmarkets.com/research/h5gm8z/global?w=4

View source version on businesswire.com: http://www.businesswire.com/news/home/20180216005247/en/

Business Wire
www.businesswire.com

Last updated on: 16/02/2018

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