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Press Release

2018 Dengue DNA Vaccine Drug Analysis -

Research and Markets
Posted on: 21 Feb 18

The "Drug Analysis: Dengue DNA vaccine" drug pipelines has been added to's offering.

The US Naval Medical Research Center (NMRC) is developing a Vaxfectin (cationic lipid-based adjuvant; Vical)-adjuvanted, tetravalent plasmid DNA vaccine. In 2008, Vical entered into an agreement with the NMRC to manufacture the vaccine, but it does not currently have a license for further development. However, the vaccine utilizes Vical's proprietary Vaxfectin adjuvant, so commercialization would require a licensing agreement with Vical. The DNA vaccine is currently in Phase I development in the US only.

The vaccine comprises a plasmid, encoding the pre-membrane and envelope genes of all four dengue virus serotypes (DEN-1/2/3/4). The plasmid is formulated with Vical's proprietary Vaxfectin adjuvant in a bid to increase the vaccine's immunogenicity.

The vaccine is yet to be licensed by a commercial manufacturer, an. The author believes that this is unlikely to occur based on disappointing Phase I data and the lack of announcements regarding Phase II studies. If the DNA vaccine were to progress to Phase II development, it is likely to be targeted for use in military personnel, where its compacted three-dose schedule (days 0, 30, and 90) would be more attractive than that of Dengvaxia (tetravalent live-attenuated chimeric vaccine; Sanofi Pasteur).

However, the vaccine could face fierce competition in this segment from Merck & Co's V180 (adjuvanted, tetravalent DEN-80E subunit vaccine) and GlaxoSmithKline's DPIV (adjuvanted, tetravalent formalin-inactivated vaccine), which also possess shortened two- or three-dose schedules.

Key Topics Covered:

Product Profiles

Dengue DNA Vaccine

List of Figures

Figure 1: Dengue DNA Vaccine for dengue fever - SWOT analysis

List of Tables

Table 1: Dengue DNA Vaccine drug profile

Table 2: Dengue DNA Vaccine Phase I data in dengue fever

Table 3: Dengue DNA Vaccine Phase I data in dengue fever

Table 4: Potential dosing schedules of early-phase dengue fever vaccine candidates

For more information about this drug pipelines report visit

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Business Wire

Last updated on: 21/02/2018

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