Pharmiweb ChannelsAll | PharmaCo | Clinical Research | R&D/BioTech | Sales/Mktg | Healthcare | Recruitment | Pharmacy | Medical Comms

Pharmiweb.com RSS Feed Pharmiweb.com RSS Feeds

Advertising

Press Release

iTeos Therapeutics to Present Preclinical Data from A2A Receptor Antagonist and Anti-TIGIT Antibody Programs at AACR

iTeos Therapeutics SA
Posted on: 12 Apr 18

iTeos Therapeutics to Present Preclinical Data from A 2A Receptor Antagonist and Anti-TIGIT Antibody Programs at AACR

Gosselies, Belgium - April 12, 2018 - iTeos Therapeutics SA, a biotechnology company developing novel cancer immunotherapies, today announced that it will present data for its A 2A antagonist and anti-TIGIT antibody programs in two abstracts at the upcoming American Association for Cancer Research (AACR) Annual Meeting, taking place from April 14-18, 2018 in Chicago, IL.

"We continue to make good progress advancing our best-in-class A 2A receptor antagonist and our promising anti-TIGIT antibody toward the clinic and are delighted to present this data at AACR," said Michel Detheux, Ph.D., Chief Executive Officer of iTeos. "After the advancement of the A 2A receptor antagonist program into the clinic in 2018, the anti-TIGIT antibody will follow in 2019, fortifying our position as a leading player in the immunotherapy field."

Adenosine A 2A Receptor Inhibitor (EOS100850): Best-in-class A 2A receptor antagonist program currently being evaluated for safety and efficacy in preclinical models with a Phase I trial expected to begin in 2018.

Presentation Title: EOS100850, an insurmountable and non-brain penetrant A 2A receptor antagonist, inhibits adenosine-mediated T cell suppression, demonstrates anti-tumor activity and exhibits best-in class characteristics

Session Title: Late-Breaking Research: Immunology 2
Session Date and Time: Tuesday, April 17, 2018 from 1:00 PM - 5:00 PM CT
Session Location: Poster Section 44

Human Anti-TIGIT Antibody (EOS884448): Antagonist antibody against human TIGIT that demonstrates a classical human IgG pharmacokinetics profile. It is currently being evaluated for safety and efficacy in preclinical models with a Phase I trial expected to begin in 2019.

Presentation Title : A TIGIT antagonist antibody EOS884448 shows dual mechanism of action by restoration of T cell effector functions and preferential depletion of Treg

Session Title: Late-Breaking Research: Immunology 1
Session Date and Time: Monday, April 16, 2018 from 8:00 AM - 12:00 PM CT
Session Location: Poster Section 45

About iTeos' Adenosine A 2A Receptor Inhibitor (EOS100850)
The adenosine A 2A receptor is the main adenosine receptor expressed on immune cells, which promotes immune suppression, leading to tumor evasion. iTeos' best-in-class A 2A receptor antagonist, EOS100850, restores T-cell activation inhibited by adenosine. EOS100850 promotes anti-tumor efficacy in mouse tumor models in combination with several immune-checkpoint inhibitors, retains high potency in the presence of elevated intra-tumoral adenosine concentrations, and is non-brain penetrant. EOS100850 is currently being evaluated for safety and efficacy in preclinical models.

About iTeos' Human Anti-TIGIT Antibody (EOS884448)
TIGIT is an immunosuppressive receptor expressed on lymphoid cell populations. TIGIT expression increases in cancer patients and marks exhausted T cells. EOS884448 ­­is an antagonist antibody against human TIGIT. Preclinical studies show its potency to restore T cell function and to preferentially deplete Treg cells in cancer patient material. ADCC/ADCP-enabling isotypes of a-TIGIT surrogate Ab show potent monotherapy efficacy in murine tumor models that correlates to increased T cell activation and reduced Treg infiltration of tumors. EOS884448 demonstrates classical human IgG pharmacokinetics profile and a good developability profile. EOS884448 is currently being evaluated for safety and efficacy in preclinical models.

About iTeos Therapeutics
iTeos Therapeutics is a privately-held, clinical-stage biopharmaceutical company dedicated to extending and improving the lives of cancer patients by designing and developing next generation immunotherapies. The Company is advancing EOS100850, an insurmountable and non-brain penetrant adenosine A 2A receptor antagonist, into a Phase I trial in the second half of 2018. A second program for its human ADCC-enabling anti-TIGIT antibody (EOS884448) is expected to enter the clinic in 2019. The company is currently also evaluating its third program, EOS200271, a clinical-stage potent and selective IDO1 inhibitor. Based in Gosselies, Belgium, iTeos Therapeutics was founded out of the Ludwig Institute for Cancer Research (LICR) and the de Duve Institute in 2011, with funds from the LICR, the Walloon Region of Belgium and the European Fund for Economic and Regional Development (FEDER). For more information, please visit www.iteostherapeutics.com .

For further information, please contact:
Michel Detheux, CEO
iTeos Therapeutics
info@iteostherapeutics.com

Amber Fennell, Mathew Neal, Sukaina Virji, Hendrik Thys
Consilium Strategic Communications
+44 203 709 5700
iteos@consilium-comms.com

Sarah McCabe
Stern Investor Relations, Inc.
+ 1 212 362 1200
sarah@sternir.com



This announcement is distributed by Nasdaq Corporate Solutions on behalf of Nasdaq Corporate Solutions clients.

The issuer of this announcement warrants that they are solely responsible for the content, accuracy and originality of the information contained therein.

Source: iTeos Therapeutics SA via GlobeNewswire
HUG#2183753
GlobeNewswire
globenewswire.com

Last updated on: 13/04/2018

Advertising
Site Map | Privacy & Security | Cookies | Terms and Conditions

PharmiWeb.com is Europe's leading industry-sponsored portal for the Pharmaceutical sector, providing the latest jobs, news, features and events listings.
The information provided on PharmiWeb.com is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her physician.