Pharmiweb ChannelsAll | PharmaCo | Clinical Research | R&D/BioTech | Sales/Mktg | Healthcare | Recruitment | Pharmacy | Medical Comms RSS Feed RSS Feeds


Press Release

ProMIS Neurosciences Issues White Paper Entitled 'State of the Art at AAIC 2018'

ProMIS Neurosciences
Posted on: 31 Jul 18
Key conference theme: targeting toxic amyloid-beta oligomers offers renewed hope for treatment of Alzheimer's disease 

TORONTO and CAMBRIDGE, Mass., July 31, 2018 (GLOBE NEWSWIRE) -- ProMIS Neurosciences, Inc. (TSX:PMN) (OTCQB:ARFXF), a biotechnology company focused on the discovery and development of antibody therapeutics targeting toxic oligomers implicated in the development of neurodegenerative diseases, today announced it has issued a white paper entitled 'State of the Art at AAIC 2018'.

At this year's Alzheimer's Association International Conference (AAIC), the causative role of  amyloid-beta oligomers (ABO) in the development and progression of Alzheimer's disease (AD) and the importance of neutralizing ABO toxicity represented a common theme across multiple oral presentations and posters. These included details of the recent positive Phase 2 clinical results obtained with BAN2401 by Eisai/Biogen showing a dose-dependent reduction in cognitive decline compared to placebo at 12 and 18 months.

"Overall, the BAN2401 results provide strong support for targeting of ABO as a therapeutic strategy for AD. However, the encouraging results reported leave room for improvement, due to the brain swelling (ARIA) associated with plaque binding in the higher BAN2401 dose groups," stated Dr. Elliot Goldstein, ProMIS President and CEO. 

"As outlined in our poster presentation at the AAIC, humanized PMN310 shows unrivaled selectivity for native toxic ABO derived from human AD brains, with no off-target binding to AB monomers or plaque. We believe the oligomer selectivity of PMN310 supports a potential best in class product profile compared to other therapeutic antibodies currently showing promising results in clinical trials."

Another topic of high interest centered around advancements in the use of biomarkers driven by the convergence of emerging results from several large longitudinal studies together with recent FDA guidance encouraging the use of cerebrospinal fluid (CSF) and imaging biomarkers in clinical testing.

ProMIS' clinical candidate, humanized PMN310, is on track to enter Phase 1 clinical testing in the second half of 2019 and will include biomarker assessment as an integral part of the study design.

ProMIS white paper, entitled  ' State of the Art at AAIC 2018'  can be found on the ProMIS website, by clicking on the link below:

ProMIS AAIC poster presentation, entitled ' Humanized PMN310 shows enhanced therapeutic potential by binding toxic low molecular weight AB oligomers while avoiding ARIA-related binding to AB deposits in AD patient brains ' can be found on the ProMIS website, by clicking on the link below:

About ProMIS Neurosciences, Inc.

ProMIS Neurosciences is a development stage biotechnology company focused on discovering and developing antibody therapeutics targeting toxic oligomers implicated in the development of  neurodegenerative diseases, in particular Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD). The Company's proprietary target discovery engine is based on the use of two complementary techniques. The Company applies its thermodynamic, computational discovery platform-ProMIS(TM) and Collective Coordinates - to predict novel targets known as Disease Specific Epitopes (DSEs) on the molecular surface of misfolded proteins. Using this unique precision medicine approach, the Company is developing novel antibody therapeutics for AD, ALS and PD.  ProMIS is headquartered in Toronto, Ontario, with offices in Cambridge, Massachusetts. ProMIS is listed on the Toronto Stock Exchange under the symbol PMN.TO, and on the OTCQB Venture Market under the symbol ARFXF.
For further information please consult the Company's website at:

Follow us on Twitter
Like us on LinkedIn

Media inquiries for ProMIS
David Schull
Tel. 858 717-2310

Investor Relations inquiries for ProMIS
Alpine Equity Advisors
Nicholas Rigopulos, President
Tel. 617 901-0785

Dr. Elliot Goldstein
President and Chief Executive Officer, ProMIS Neurosciences Inc.
Tel. 415 341-5783

Neither the TSX nor its Regulation Services Provider (as that term is defined in the policies of the TSX) accepts responsibility for the adequacy or accuracy of this release.  This news release contains certain "forward-looking statements" within the meaning of Canadian securities legislation. Forward-looking statements are statements that are not historical facts; they are generally, but not always, identified by the words "expects", "plans", "anticipates",  believes", "intends", "estimates", "projects", "aims", "potential", "goal", "objective", "prospective", and similar expressions, or that events or conditions "will", "would", "may", "can", "could" or "should" occur. Forward-looking statements are based on the beliefs, estimates and opinions of the Company's management on the date the statements are made and they involve a number of risks and uncertainties. Consequently, there can be no assurances that such statements will prove to be accurate and actual results and future events could differ materially from those anticipated in such statements. Except as required by the securities disclosure laws and regulations applicable to the Company, the Company undertakes no obligation to update these forward-looking statements if management's beliefs, estimates or opinions, or other factors, should change.

This announcement is distributed by Nasdaq Corporate Solutions on behalf of Nasdaq Corporate Solutions clients.

The issuer of this announcement warrants that they are solely responsible for the content, accuracy and originality of the information contained therein.

Source: ProMIS Neurosciences via GlobeNewswire

Last updated on: 01/08/2018

Site Map | Privacy & Security | Cookies | Terms and Conditions is Europe's leading industry-sponsored portal for the Pharmaceutical sector, providing the latest jobs, news, features and events listings.
The information provided on is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her physician.