Pharmiweb ChannelsAll | PharmaCo | Clinical Research | R&D/BioTech | Sales/Mktg | Healthcare | Recruitment | Pharmacy | Medical Comms

Pharmiweb.com RSS Feed Pharmiweb.com RSS Feeds

Advertising

Press Release

Aurigene to Present Multiple Programs at the SITC 2018 in Washington D.C. and EORTC-NCI-AACR 2018 in Dublin

Aurigene
Posted on: 05 Nov 18

Aurigene:

SITC – Nov 7-11, Washington D.C.:

(a) CA-170 - Small molecule oral antagonist of PD-L1/VISTA in Ph-2 (India)
(b) Small molecule oral antagonist of CD47
(c) Small molecule oral antagonist of TIGIT/PD-L1

EORTC-NCI-AACR – Nov 13-16, Dublin:

a. Covalent, highly selective CDK12 inhibitors
b. Degrader of SMARCA2/4
c. Dual antagonists of TIGIT and PD-1 pathways
d. Dual inhibitors of CD73 and A2AR

Details: SITC, Nov 7-11 Washington D.C.

CA-170 Small Molecule Oral Antagonist Targeting PD-L1/VISTA
Title: Phase 2 trial of CA-170, a novel oral small molecule dual inhibitor of immune checkpoints VISTA and PD-1, in patients with advanced solid tumor and Hodgkin lymphoma
Abstract Number: P714
Session Details: Late Breaking
Date & Location: Friday, Nov. 9 from 8 a.m. to 8 p.m. and Saturday, Nov. 10 from 8 a.m. to 8:30 p.m. Hall. E

Small Molecule Oral Antagonist Targeting CD47
Title: Efficacy and safety profile of AU7R-104, a small molecule targeting CD47/SIRPα pathway
Abstract Number: P529
Session Details: Innate Anti-Tumor Immunity (NK cells, monocytes, macrophages, etc.)
Date & Location: Friday, Nov. 9, from 12:45 – 2:15 p.m. and 6:30 – 8 p.m. Hall E

Small Molecule Oral Antagonist Targeting TIGIT/PD-L1 Pathways
Title: An orally bioavailable small molecule dual antagonist of TIGIT and PD-L1 pathways shows immune-mediated anti-tumor activity
Abstract Number: P694
Session Details: T-cell Checkpoints and Checkpoint Inhibitors
Date & location: Saturday, Nov. 10 from 12:20 – 1:50 p.m. and 7:00 – 8:30 p.m. Hall E

More details: https://www.sitcancer.org/2018/abstracts/titles

Details of Poster Presentations at EORTC-NCI-AACR, Nov 13-16, Dublin

Covalent Selective CDK12 Inhibitors
Title: Potent anti-tumor activity correlated with inhibition of DNA damage response genes with highly selective and orally bioavailable CDK12 covalent inhibitors
Poster Session: "Drug Design" on 15 November 2018
Poster Time: Thursday 15 November: 10.00-17.30
Poster Abstract Number: 280
Poster Board Number: PB041

SMARCA2/4 Degraders
Title: In vivo anti-tumor efficacy with a dual degrader of SMARCA2 and SMARCA4
Poster Session: "Molecular Targeted Agents - PART II" on 16 November 2018
Poster Time: Friday 16 November: 10.00-14.00
Poster Abstract Number: 411
Poster Board Number: PB074

Small Molecule Oral Antagonists Targeting TIGIT/PD-L1 Pathways
Title: Oral immune checkpoint antagonists dually targeting TIGIT and PD-1 pathways for cancer therapy
Poster Session: "Immune Checkpoints" on 14 November 2018
Poster Time: Wednesday 14 November: 10:00-17:30
Poster Abstract Number: 230
Poster Board Number: PB081

Dual Inhibitors of CD73 and A2AR
Title: First-in-class dual inhibitors of CD73 and A2AR for effective suppression of the adenosine signaling pathway to improve anti-tumor immunity
Poster Session: "Late Breaking Poster Presentation" on 13-16 November 2018
Poster Time: Tuesday 13 November: 12.00-18.30; Wednesday 14 November: 10.00-17.30;
Thursday 15 November: 10.00-17.30; Friday 16 November: 10.00-14.00
Poster Abstract Number: LBA17
Poster Board Number: PB220

More details: https://www.ecco-org.eu/Events/ENA2018/Scientific-Programme-and-Abstracts

About Aurigene
Aurigene’s Proprietary Programs business is engaged in discovery and clinical development of novel and best-in-class therapies to treat cancer and inflammatory diseases. Aurigene’s pipeline is focused on oral check-point inhibitors, transcriptional CDK inhibitors (CDK7 and CDK12) and protein degraders focused on the chromatin remodeling complex (including SMARCA2/4 degraders). Aurigene’s oral PD-L1/ VISTA antagonist program is currently in Phase 2 (trial initiated by Aurigene in India). Aurigene has initiated a Phase I study for its RORg program for autoimmune diseases in July 2018 and expects to initiate Phase 2 studies by early 2019. Aurigene’s selective CDK7 inhibitor is slated for an IND by Q1 2019 and CDK12 inhibitor by end-2019. More details of our pipeline can be found at: http://www.aurigene.com/proprietary-programs/.

View source version on businesswire.com: https://www.businesswire.com/news/home/20181105005435/en/

Business Wire
www.businesswire.com

Last updated on: 05/11/2018

Advertising
Site Map | Privacy & Security | Cookies | Terms and Conditions

PharmiWeb.com is Europe's leading industry-sponsored portal for the Pharmaceutical sector, providing the latest jobs, news, features and events listings.
The information provided on PharmiWeb.com is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her physician.