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Job Details

Downstream Process Scientist

Company: Thornshaw Recruitment
Reference: ND9592
Closing Date: 16 Feb 18
Type: Permanent
Salary (£): On Application

Job Summary:

My client, a biopharmaceutical company in Leinster, is looking for a Downstream Process Scientist to join their team.


The Downstream Process Scientist will be responsible for the development and validation of processes for recombinant antibodies for veterinary use.  This will include technical transfer of processes into the company facility.


The Downstream Process Scientist will be responsible for the following:

  • To support the development, optimisation, scale-up and validation of all steps in the company’s monoclonal antibody downstream processes.
  • Work with external partners to provide the necessary technical support for successful completion of projects including the transfer of processes into the facility
  • Support the writing of Batch Manufacturing Records, SOPs, and other quality system documentation required for GMP manufacture
  • Provide hands-on technical support for all manufacturing activities including buffer / media preparation, cell culture and purification processes
  • Provide technical input and support writing of technical reports required for regulatory purposes
  • Participate in Quality and Safety regulatory audits
  • Identify continuous improvement initiatives
  • Carry out manufacturing as per Batch Records using chromatography and ultrafiltration diafiltration steps.
  • Complete buffer preparation for process steps.
  • Filter integrity testing and virus clearance steps in the downstream process.


Applications are welcome from candidates with the following or similar experience:

  • M.S. in Chemical/Biochemical Engineering or related Biological Sciences with ³ 2 years of industrial experience OR B.S in Chemical/Biochemical Engineering or related Biological Sciences with ³ 5 years of industrial experience.
  • Previous hands-on experience running chromatography systems and filtration systems is required.
  • Experience developing and scaling up of downstream processes is preferred.
  • Protein purification, lab-scale and pilot scale
  • Knowledge of analytical methods required for protein characterisation
  • Excellent verbal and written communication skills. Ability to maintain very clear records of work completed
  • Knowledge and understanding of the workings of protein purification techniques using Unicorn software is required.
  • Understanding of process characterisation and ability to write risk assessments and technical documents.

For further details and to apply for this role please contact Nicola at +353 1 2784671 or email your CV to


Thornshaw Scientific Recruitment is a leading Irish provider of specialist Scientific Recruitment. Part of the CPL Group.

Apply for this job: Downstream Process Scientist

Contact Information:

Address:  Head Office
Barton House 6 Old Dublin Road Stillorgan Co. Dublin

Rep. Ireland
Tel:  00 353 (1) 278 4671
Fax:  00 353 (1) 278 4672
Website:  Visit Our Web Site

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