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Job Details

Principal Pharmacometrician 

Company: RBW Consulting
Location: East-Coast USA
Reference: IKPMXP-6329
Closing Date: 21 Mar 18
Type: Full Time
Salary (£): Competitive
Benefits: Highly Competitive Package offered

Job Summary:

Innovative, global Pharma currently seeking an experienced Pharmacometrician to take on project leading responsibilities.


Principal Pharmacometrician 

Greater New York Area

The Principal Pharmacometrician will apply quantitative approaches to develop and implement translational PK/PD strategies, characterize clinical pharmacokinetics and pharmacodynamics of new chemical entities and biologics, and inform dose selection and go/no-go decisions. Principal Scientists will perform responsibilities independently with minimal supervision, and mentor others to develop similar capabilities. You will lead efforts on drug development programs, and author strategic documents. You are expected to have or be developing expertise in several areas, including:

  • Serving as an expert representative on drug/vaccine development teams
  • Framing critical drug development questions for optimizing model-based development
  • Developing and executing translational PK/PD models, population pharmacokinetic models, exposure-response and, stratification biomarker models, quantitative system pharmacology (QSP) and disease progression models, clinical trial design via outcome/enrollment modeling and simulation, comparator modeling, absorption/biopharmaceutical modeling, clinical utility index modeling, and other model-based analyses
  • Maintaining a comprehensive understanding of global regulatory expectations for small molecules and biologics, authoring regulatory documents (INDs, CSRs, CTDs), and representing pharmacometrics at regulatory meetings
  • Overseeing a group of scientists (in a scientific and/or supervisory role) 
  • Mentoring and/or supervising junior colleagues to perform the above duties and to develop the above capabilities


The Principal Scientist is a skilled modeler and a quantitative drug/vaccine developer, with a strong, integrated understanding of the strategic elements of drug discovery and development, and leads the combined efforts of Pharmacometrics alongside the wider Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM).  You will develop strategies for quantitative analyses within and across development programs and/or functions. In addition to the responsibilities described above, Principal Scientists demonstrate outstanding leadership and communication skills. They collaborate within Pharmacometrics teams and with other functional areas, as well as with external vendors and partners, creating an aligned, quantitative framework to impact strategies and decisions of drug development teams. 



  • MSc or equivalent degree with at least 11 years of experience 
  • Ph.D. or equivalent degree with 7+ years of experience or a Pharmaceutical Doctor or equivalent degree with at least nine years of experience in a similar role in pharmaceutical drug development or academia
  • Educational background in biopharmaceutics, pharmaceutical sciences, pharmacometrics, mathematics, statistics/biostatistics, computational biology/chemistry, chemical/biomedical engineering, or a related field.
  • Proficiency in R, Matlab, SAS, or other similar programing language



  • An exemplary record of increasing responsibility, independence, and demonstrated impact in driving drug development decisions through application of model-based approaches in the pharmaceutical industry
  • Experience in performing population PK / PKPD and non-compartmental analyses using standard pharmacometric software (e.g. NONMEM, Monolix, Phoenix, etc.)
  • Expert skills in experimental design, mathematical problem solving, critical data analysis/interpretation, and statistics
  • Scientific understanding of biopharmaceutical and ADME properties 
  • Proficiency in written and verbal communication, interdisciplinary collaboration, and problem scoping and planning
  • Demonstrated ability to participate in and to lead an interdisciplinary team, and to oversee the work of other scientists


I manage a range of other permanent and freelance positions for a broad portfolio of clients, so if the above role isn’t for you but you’d nevertheless like to discuss other opportunities currently available both now and in the near future, we are happy to get in touch at your discretion. Contact Ian Kulka at 617 982 1238 today!

Apply for this job: Principal Pharmacometrician 

Contact Information:

Address:  Head Office
Origin Two 106 High Street, Crawley RH10 1BF
RH10 1BF
Tel:  01293 584 300
Fax:  01293 534 133
Website:  Visit Our Web Site

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