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Job Details

Senior Protein Scientist

Company: Clinical Professionals Ltd
Location: Cambridgeshire
Reference: JO-1806-411557
Closing Date: 29 Dec 18
Type: Full Time
Salary (£): Competitive
Benefits:

Job Summary:

Our client is at the forefront of shaping the future of medicine by developing completely new & proprietary protein therapeutics with their ground-breaking platform.

Requirements:

Our client is at the forefront of shaping the future of medicine by developing completely new & proprietary protein therapeutics with their ground-breaking platform. Their aim is to establish their technology in-line with the growing demand for the next generation of biotherapeutics, surpassing monoclonal antibody therapeutics.

Theyre looking for a unique & driven protein Scientist to express and characterise their technology through phage display, as well as identify, develop & engineer leads for pre-clinical studies.

Duties & Responsibilities:
- Clone, express, purify and characterise proteins for binding, stability & characterisation studies across a range of expression platforms.
- Clone, express, purify and characterise recombinant antigen proteins for phage screens & ELISA or cell-based assays through a range of platforms and completely characterise them using a range of analytical methods.
- Establish and maintain cell lines for protein production.
- Engineer protein constructs with serum half-life extension technologies & design, clone, express & characterise the proteins that are produced.
- Develop SOPs and protocols.
- Carry out assays using HPLC to characterise protein batches.
- Carry out accelerated stability studies on in-house proteins and characterise changes that may occur.
- Establish formulation studies for increasing stability of the proteins produced
- Carry out R&D projects to improve their protein platform for therapeutic development such as improving the biophysical properties of the scaffold
- Present work/data at internal group/company meetings when necessary and produce accurate scientific reports.
- Maintain a current and accurate laboratory record (electronic lab notebook) of all activities
Skills & Experience
- A MSc/PhD in protein biochemistry, protein engineering or molecular biology with a minimum of 2-4 years laboratory experience of working with therapeutic protein scaffolds or antibodies
- Standard DNA manipulation/cloning techniques and protein engineering including working with a range of protein expression platforms (bacterial, Pichia and mammalian)
- Mammalian cell culture - culturing and maintaining cell lines, transfections for protein production. Large-scale protein production experience would be an advantage
- Practical knowledge of the AKTA purification platform, Unicorn software and using conventional chromatography resins e.g. ion exchange
- Developing HPLC based assays for protein characterisation
- Excellent knowledge of a range of methodologies to characterise proteins (e.g. SPR, ELISA, Western blot)
- A good understanding of protein engineering and protein biophysics to investigate structure/functional relationships would be an advantage.
- Knowledge or experience of protein NMR and crystallography would also be an advantage.
- Motivated self-starter who can work independently and collaboratively in a dynamic team environment with a conscientious attitude and enthusiasm
- Excellent written and verbal communication skills
- Strong analytical and critical thinking skills with the ability to interpret complex data
- Organised with an ability to work well under pressure and to challenging timelines


If this role sounds like it could be of interest to you, or you would like to find out more about the position, client or process, please contact Matthew Walsh on 0207 822 1710 or email an up to date version of your CV to matt@scientificprofessionals.com.

If however, you do not feel that this is the right role for you, please forward these details on as we do have a generous referral scheme in place. Please note, due to the high volume of applications, if you do not receive a response within 48 hours, your application has not been successful on this occasion.

Apply for this job: Senior Protein Scientist

Contact Information:

Address:  Clinical Professionals Ltd
33 Blagrave Street,
Reading
RG1 1PW
England
Tel:  0118 959 4990
Fax:  0118 956 0607
Website:  Visit Our Web Site

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