Pharmiweb ChannelsAll | PharmaCo | Clinical Research | R&D/BioTech | Sales/Mktg | Healthcare | Recruitment | Pharmacy | Medical Comms

Pharmiweb.com RSS Feed Pharmiweb.com RSS Feeds

Advertising

Feature

Abbott - Pipeline going from strength to strength

Posted on: 24 Feb 06

Summary

Abbott recently had the largest gain in reputation of any company in its industry when Fortune magazine ranked it number three in the magazine’s list of the most admired companies in the United States – Fortune’s highest ranking for Abbott since 1989. How was this achieved and what factors led up to it?

Abbott recently had the largest gain in reputation of any company in its industry when Fortune magazine ranked it number three in the magazine’s list of the most admired companies in the United States – Fortune’s highest ranking for Abbott since 1989. How was this achieved and what factors led up to it?

In April 2005, Miles White, Abbott’s CEO, summed up the previous year’s performance in one word – “Excellent”. Five years ago, it was clear that the company would have to reposition itself yet again in
order to ensure a future as successful as its past and to carry on Abbott’s legacy for all those who depend on the company – from patients to staff and beyond.

Abbott rationalised its business structure for focus and performance, pulling together the pieces of pharma business that used to be spread across different organisations. Today, Abbott is working as a global
team and focusing its discovery resources on five integrated core therapeutic areas – immunology, infectious disease, diabetes/metabolism, oncology and neuroscience/pain management. Abbott is driven by a straightforward purpose: to focus on serving
patients with superior science across a broad base of technologies and
businesses.

The company has an enviable robust pipeline, with a stream of drugs lined up for market introduction within the next few years and a total of 120 candidates in the advanced preclinical stage. Abbott has been achieving top-tier financial performance, and its success is being recognised – by industry observers, by its
stakeholders, by its peers and by investors.

“Abbott’s mission is to create a top-tier global
pharmaceutical business capable of consistently
discovering, developing and marketing
breakthrough drugs to improve patient health.
This will deliver sustained double-digit sales
and margin growth for Abbott.”
– Jeff Leiden
President and COO, Pharmaceutical Products Group, Abbott

In the past five years, Abbott has increased its R&D investment significantly. In 2004, Abbott spent $1.7 billion on R&D and there are more than 5,000 scientists and engineers at work, pushing the frontiers of its fields and developing products that fill the unmet needs of
patients, healthcare professionals and consumers.
Abbott’s investments are already producing results.

In 2004, Abbott completed a number of significant development programmes. Its Pharmaceutical Products Group submitted seven regulatory applications to the US Food and Drug Administration (FDA) for new medications – a record for Abbott. Abbott’s science has been raised to a new level across its entire range of technologies and businesses and has challenged the
company on all fronts.

Abbott has worked hard to build a world-class global R&D function in recent years, investing in advanced technologies that support faster discovery, development and approval of new medicines. Led by Dr Jeff Leiden, President and Chief Operating Officer of Abbott’s


Pharmaceutical Products Group, Abbott took a strategic decision to focus its R&D effort on fewer therapeutic areas for the more productive use of scientific resources.


“We’re focusing on developing breakthrough drugs rather than ‘me too’ drugs,” says Dr Leiden.
The areas of focus narrowed from thirteen to five, concentrating on where the company has extensive expertise and where it can make the greatest impact in bringing forward important new medicines for
patients.


Shorter R&D Timeframes
With a greater focus on quality going into the pipeline and optimising R&D processes, Abbott is already reaping the rewards with compounds coming through development in much shorter timeframes. Kaletra® (lopinavir/ritonavir), for example, was licensed for use in the UK only six years after it was discovered, and HUMIRA® (adalimumab) had been in development for only seven years when it received EMEA
approval in 2003 for the treatment of rheumatoid arthritis.


Pharmaceutical Innovation
Within this new business framework, Abbott plans to launch five new products or additional indications in the UK over the next three to four years, which should boost sales at Abbott UK by around 70% by 2010

A number of impressive developments in 2005 clearly demonstrate how far Abbott has advanced in recent years. In May 2005, Zemplar® (paricalcitol injection) was launched in the UK for the prevention and treatment of secondary hyperparathyroidism
(SHPT) in dialysis patients with end stage renal disease.


Three months later, the European Commission approved HUMIRA for the treatment of:
• severe, active and progressive rheumatoid arthritis in methotrexate naïve patients
• active and progressive psoriatic arthritis in adults when response to previous disease-modifying anti-rheumatic drug therapy has been inadequate.

In October 2005, Abbott filed for use of HUMIRA in ankylosing spondylitis (arthritis of the spine) and over the next several years, Abbott expects to file for use of HUMIRA in Crohn’s Disease, psoriasis and juvenile rheumatoid arthritis.


“. . . Abbott’s promising pipeline of
experimental drugs and medical devices . . .
should ensure double-digit earnings
growth through 2007.”
– Reuters

In the fourth quarter, Abbott received FDA approval for a new, more convenient formulation of Kaletra which does not need refrigeration and will allow patients to take fewer tablets per dose as part of their
treatment regimen. An application for this formulation was also submitted to the EMEA in June.
On the oncology front, Abbott received permission from the FDA to initiate an expanded access programme for XinlayTM (atrasentan) for men with metastatic, hormone-refractory prostate cancer. Its potential
benefit is also being investigated in other cancers, including ovarian, brain and renal cell cancers.
Abbott is completing its clinical development programme for Simdax® (levosimendan), a novel therapy for the treatment of congestive heart
failure. All in all, an enviable programme of product development.


“We continue to believe Abbott’s pipeline
remains under-appreciated.”
– Bank of America Securities

Abbott is entering the 21st century as a dynamic company with much breakthrough innovation still ahead. Abbott sees its staff as critical components of its business and encourages the sharing of knowledge and interaction of disciplines, and it believes transparency
and collaboration are key to industry success. Indeed, Abbott’s staff are the key to the pipeline’s success and pioneering spirit.

Abbott’s strength comes from the three key determinants of success it sees in the years ahead: business breadth, superior science and taking action to help patients access its medicines.

If you would like to join a pioneering company,
please call the HR Department on 01628 773355.

 

This feature has previously been posted in the Pharmaceutical Field Magazine

Caroline Johnson

Last updated on: 27/08/2010 11:40:18

Advertising
Site Map | Privacy & Security | Cookies | Terms and Conditions

PharmiWeb.com is Europe's leading industry-sponsored portal for the Pharmaceutical sector, providing the latest jobs, news, features and events listings.
The information provided on PharmiWeb.com is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her physician.