CPhI Annual report forecasts CMOs to benefit from double digit approvals for ADCs in the next 3-years.
Summary of trends forecast: the next 1-3 years
- Novel payloads that target tumour-initiating cells on third generation ADCs could come to market in the next couple of years
- ADCs market forecast to expand at nearly 20% CAGR until 2030 driven by a healthy late stage pipeline.
- Outsourcing of ADC manufacturing will continue, with increased co-development – driven by increased needs from biotechs needing specialist development expertise and facilities.
- Longer term (circa 5-years) the expansion of ADCs into therapeutic areas other than oncology will be the next evolution – bioconjugation in infectious disease is one potential area
Madrid, 9th October 2018: The global ADC therapeutics market is expected to grow to $4bn by 2023, with double digit approvals within 3-years, according to a new analysis in the CPhI Annual Report – the complete findings of which were released live at CPhI Worldwide in Madrid (9-11, October 2018).
CPhI Annual Report expert Vivek Sharma, CEO of Piramal Pharma Solutions, expects the global market for ADCs to grow at around 19% CAGR between 2017 and 2030 and reach an estimated value of $4 billion in the next five years, with 17 drugs that are either approved or in late stages of clinical development, catalysing such growth.
“The last few years have seen a progressive evolution of targets from first to second and third generation Antibody Drug Conjugates (ADCs), which is now accelerating growth as new compounds are more targeted, more druggable and potentially have a better chance for approval.” commented Vivek Sharma
The understanding of site-specificity and homogenously conjugated ADCs has accelerated the FDA approval rate and has led to dramatic increase in the number of clinical trials, especially in solid tumours. In total there are now 600 clinical trials being conducted worldwide on ADCs, with 202 ADCs entering clinical trials – out of which 116 are actively progressing. Most encouragingly, there has been an increase of 30% in the last 12 months with 23 new ADCs entering clinical trials.
The report outlines that CMO’s and CDMO's are particularly well set to capitalise on this growing therapeutic product class, and may even lead to new business models, such as co-development partnerships, particularly amongst smaller and medium sized biotechs.
“The global market for ADCs is expected to be driven by the advancement in medical technology, rising incidence of cancer, and an increasing demand for biologic therapies. In the quest for more targeted therapies and potentially more clinically efficacious drugs, bio/Pharma companies are increasing their research and product development in biologics” added Sharma.
Due to technical challenges associated with ADC manufacturing and the substantial investment involved on safety and hazardous material equipment, Vivek estimates that around 70% of ADC manufacturing is outsourced to CMOs. This is expected to rise, particularly for horizontally integrated CDMOs, along with co-development business models, driven by biotechs and smaller companies that need specialist development expertise and facilities.
In the long term, the Annual Report also highlights that ADCs are now being utilized in other therapeutic products classes beyond oncology. Specifically, ADCs are projected to provide more targeted therapeutics in infectious diseases (against multi drug resistant bacteria) and chronic conditions such as autoimmune and cardiovascular diseases.
CPhI Brand Director Europe, Orhan Caglayan added: “The findings in the full CPhI Annual Report further reinforces that there is a clear bridge now forming between small and large molecule industries, with the cross sharing of knowledge in the ADC market leading to less clinical attrition and greater approvals. So whilst it is clearly good news for CPhI and bioLIVE – as we combine small and large molecule exhibitions in 2018 – the market also looks extremely promising for CDMOs, and the wider outsourcing industry with over 70% of future manufacturing set to be contracted to specialist providers. So I encourage all of our attendees at CPhI Worldwide to engage both these findings and with the wider industry this week – by establishing new partnerships we will help accelerate development of the global market”.
The full findings of the CPhI Annual Report – including 11 in-depth expert contributions as well as the CPhI Manufacturing and Bio leagues tables – are available for free at https://www.cphi.com/europe/cphi-annual-report
CPhI drives growth and innovation at every step of the global pharmaceutical supply chain from drug discovery to finished dosage. Through exhibitions, conferences and online communities, CPhI brings together more than 100,000 pharmaceutical professionals each year to network, identify business opportunities and expand the global market. CPhI hosts events in Europe, Korea, China, India, Japan, South East Asia, North America, and the Middle East and Africa. Co-locating with ICSE for contract services; P-MEC for machinery, equipment & technology; InnoPack for pharmaceutical packaging; BioPh for biopharma; and Finished Dosage Formulation for every aspect of the finished dosage supply chain. CPhI provides an online buyer and supplier directory at CPhI-Online.com.
For more information visit https://www.cphi.com
About UBM (and parent company Informa)
CPhI is organised by UBM, which in June 2018 combined with Informa PLC to become a leading B2B information services group and the largest B2B Events organiser in the world.
The UBM annual schedule of Pharmaceutical events includes: BioLIVE (9-11, October, 2018 in Madrid); CPhI, ICSE, P-MEC, FDF and InnoPack Worldwide (9-11 October, 2018 at the IFEMA, Feria de Madrid – Madrid, Spain); CPhI & P-MEC India (12–14 December 2018 at the India Expo Mart, Greater Noida, Delhi NCR – Delhi, India); Pharmapack Europe (6-7 February, 2019 at the Paris Expo, Porte de Versailles – Paris, France); CPhI South East Asia (12-14 March, 2019 at the QSNCC – Bangkok, Thailand). CPhI North America (30 April - 2 May, 2019 at McCormick Place – Chicago, USA); CPhI and P-MEC China (18-20 June, 2019 at SNIEC – Shanghai, China). CPhI Korea (21-23 August 2019, COEX – Seoul, Korea); CPhI Middle East & Africa (16-18 September, 2019 at the ADNEC – Abu Dhabi, United Arab Emirates)
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