Creative Biolabs Provides One-Stop ADC Development Service
Creative Biolabs is committed to providing its clients with one-stop antibody drug conjugate(ADC) development service, featuring superior products, customized services and professional consultation about ADC development projects.
Antibody-drug conjugates (ADCs) have great potential for treating miscellaneous diseases such as cancer, fungal or bacterial infections, cardiovascular disorders, as well as immune diseases. An ADC consists of three major components–the monoclonal antibody, a cytotoxic payload, and a molecular linker that covalently bridges the other two components.
"Designing an ADC is elaborated because it involves thorough planning, careful execution and intensive problem solving. Only when the components are well combined can a successful ADC be produced. Our ADC development services are made up of six independent yet interconnected components. Specifically, at the beginning of an ADC development project, we offer antibody screening services, including consultation about antigen selection, antigen-specific antibody screening, internalization of antibody selection, as well as proof-of-concept feasibility validation," said a scientist at Creative Biolabs.
"After assembling an ADC, we will conduct a detailed analysis of its biochemical characteristics and in vitro efficacy, and assay its pre-clinical pharmacological parameters in ADC in vivo analysis before clinical evaluation and applications. Finally, to meet the needs of the fast-growing fields such as high-resolution imagery, and fast and accurate diagnostics, our company also conjugates different molecular probes to antibodies so as to form antibody-based probes."
Equipped with cutting-edge research and manufacturing facilities, Creative Biolabs boasts an advanced ADC platform covering all the critical steps in ADC development, including antibody design, chemistry synthesis, ADC manufacturing, PtLnX™ and 3D cell culture.
"The ultimate goal for an ADC development project is to cure diseases such as cancer by delivering the resulted ADC into in vivo systems. However, to determine the proceedings and directions of the ADC development project, one must acquire sufficient information about basic biochemical characteristics and in vitro efficacy. In this respect, Creative Biolabs is exactly the supplier of choice that offers comprehensive ADC in vitro analysis services," the scientist from Creative Biolabs added.
ADC analysis can help guide the ADC optimization and its downstream in vivo assessments. ADC in vitro analysis services at Creative Biolabs cover biochemical analysis(structure analysis, ADC stability analysis, DAR determination and conjugation sites analysis), in vitro efficacy evaluation(ADC affinity evaluation, internalization assays, cytotoxicity assays and ADCC and CDC assays) and 3D in vitro culture(ADC targeting profile, ADC tumor penetration and ADC solid tumor efficacy). Creative Biolabs focuses on satisfying the clients’ diverse needs, for example, for timeline and R&D budget, by tailoring specific analytical service packages.
About Creative Biolabs
Creative Biolabs, founded in 2004, provides optimal services targeting antibody biochemistry and engineering, covering the entire new drug discovery and development pipeline, ranging from early discovery, pre-clinical evaluations, cGMP manufacturing, to clinical trials. As of yet, Creative Biolabs has established leadership in targeted immunotherapy and ADC development.