Bioasis Announces Positive Results from Peripheral Whole-Body PET/CT Scan Study in Non-Human Primates with Lead Investigational Candidate xB3-001TM
Bioasis Technologies Inc. (TSX.V:BTI; OTCQB:BIOAF) (the “Company”), a pre-clinical, research-stage biopharmaceutical company developing its proprietary xB3 TM platform technology for the delivery of therapeutics across the blood-brain barrier (BBB) and the treatment of CNS disorders in areas of high unmet medical need, including brain cancers and neurodegenerative diseases, today announced data using the Company’s lead investigational candidate xB3-001 in an advanced positron emission tomography and computed tomography (PET/CT) imaging study in non-human primates suggest selective peripheral distribution. The data also indicates penetration of the lymphatic system with xB3-001.
“These findings with xB3-001 suggest that the Bioasis platform can enhance the distribution of treatments that have their efficacy limited by inability to penetrate relevant tissue compartments,” said Prof. John H. Krystal, M.D., chairman, Bioasis scientific advisory board (SAB); Robert L. McNeil, Jr., professor of translational research, chair of the department of psychiatry, and professor of neuroscience at the Yale University School of Medicine and chief of psychiatry at Yale-New Haven Hospital.
In collaboration with Invicro LLC., whole-body distribution of xB3-001 was examined in the study using advanced PET/CT imaging in non-human primates. Data from this study suggest a more selective peripheral distribution pattern for xB3-001 compared to trastuzumab alone. Importantly, the data also indicate that the xB3 platform has the potential to penetrate the lymphatic system as shown by the accumulation of xB3-001 in the cervical lymph nodes, which is not seen in trastuzumab alone.
“Together, both the peripheral distribution of xB3-001 and penetration of the lymph nodes may indicate additional benefits of xB3 fusions for patients with neurological and oncological diseases,” said Mark Day, Ph.D., lead investigator of the research; director, president and chief executive officer, Bioasis. “The potential of these findings with the xB3 platform are truly exciting and we look forward to conducting additional research as it potentially opens significant opportunities for Bioasis.”
The lymphatic system is an important target for developing new vaccines, cancer treatments and diagnostic agents. For example, most solid cancers initially spread from the primary site via the tumor’s surrounding lymphatics before hematological dissemination. Targeting the lymphatic system by subcutaneous, intestinal and pulmonary routes has been evaluated and subsequently utilized to improve lymphatic penetration as well as retention of drug molecules, reduce drug-related systemic toxicities and enhance bioavailability of poorly soluble and unstable drugs. Lymphatic imaging is an essential tool for the detection and staging of cancer.
“The xB3-001 lymphatic and lymph node penetration observed in the current study supports the utility of the xB3 platform for many CNS and non-CNS disorders,” said Mario Saltarelli, M.D., Ph.D., Bioasis SAB member; former executive vice president and chief medical officer, Syntimmune.
The Company has filed a patent application based on these observations and those data may have broader applicability.
“We are excited to collaborate with the strong team at Bioasis and very eager to work together to generate what appear to be very exciting data,” said Jack Hoppin, Ph.D., Bioasis SAB member; co-founder and chief executive officer of Invicro LLC.
Bioasis also advises investors that an updated version of its corporate presentation is available for review on its website at www.bioasis.us/investors.
On behalf of the Board of Directors of Bioasis Technologies Inc.
Mark Day, Ph.D., Director, President & Chief Executive Officer
Bioasis Technologies Inc. is a biopharmaceutical company developing the xB3TM platform, a proprietary technology for the delivery of therapeutics across the blood-brain barrier (BBB) and the treatment of CNS disorders in areas of high unmet medical need, including brain cancers and neurodegenerative diseases. The delivery of therapeutics across the BBB represents the final frontier in treating neurological disorders. The in-house development programs at Bioasis are designed to develop symptomatic and disease-modifying treatments for brain-related diseases and disorders. The company maintains headquarters in Guilford, Conn., United States. Bioasis trades on the TSX Venture Exchange under the symbol “BTI” and on the OTCQB under the symbol “BIOAF.” For more information about the company, please visit www.bioasis.us.
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