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Creative BioMart Provides Service to Support Endotoxin Removal Projects

Creative BioMart, a leading biotechnology company based in NY, provides service to help remove endotoxins (lipopolysaccharides /LPS) from aqueous solutions of a wide range of samples such as proteins, antibodies, vaccines, nucleic acids, buffers and cell extracts with excellent sample recovery rate.


Endotoxin, or lipopolysaccharide or LPS, is an integral part of the cell membrane of gram-negative bacteria, such as E. coli. The outer layer of the bacterial outer membrane is composed entirely of endotoxin molecules. A single E. coli cell contains about two million LPS molecules, each consisting of a hydrophobic lipid A moiety, a complex array of carbohydrate residues, and a negatively charged phosphate group. Widely existing in our reagent consumables and samples, it is a major pollution source in biomedical trials and pharmaceutical products, and is one of the most troublesome impurities in the purification process of biological macromolecules such as proteins, nucleic acids, and polysaccharides. Endotoxin has a strong irritation to the mammalian immune system, a very small amount of endotoxin can cause fever or even death of animal organisms, has a strong toxicity to animal cells, and seriously affects the safety of various in vitro and in vivo tests and drugs.

Endotoxin has complex structural components, containing polysaccharides, proteins, lipids and other components, with excellent thermal stability and chemical stability, which are removed by conventional methods. In order to ensure the success rate and reliability of biomedical testing, the safety and effectiveness of biomedical products, thorough removal of endotoxin from samples and solutions has become a difficult problem that scientists must overcome.


“Each endotoxin removal project requires a protocol development step that takes into account the biophysical properties of the target molecule, the final sample application, and the desired drug product. Over the years, we have successfully developed endotoxin removal protocols to meet stringent endotoxin presence requirements. We are confident that we can make your endotoxin removal program successful.” Commented Linna, the chief marketing staff at Creative BioMart.


Advantages of the service:

  • Protein losses are minimized by selection of an appropriate endotoxin removal method and its optimization
  • Endotoxin-free samples are sterilized and distributed into multiple aliquots for convenience
  • Quantitative control before and after endotoxin removal
  • More than 99.99% removal of LPS
  • Excellent sample recovery rate >95%


According to Linna, Creative BioMart also provides endotoxin related products like Endotoxin control standard, endotoxin indicator, endotoxin test kits, endotoxin removal kits, endotoxin-free purification kits, etc. for customers to choose. If more information needed, please visit



About Creative BioMart

Starting from a small supplier of proteins and enzymes for academic institutes and biotech companies, Creative BioMart has always been focusing on developing high quality protein products like recombinant proteins, native proteins, GMP proteins, etc. and efficient protein manufacturing services including protein expression, protein labeling, protein interaction etc.

Creative BioMart Provides Service to Support Endotoxin Removal Projects

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Last Updated: 29-Oct-2020