Recombinant Human Endostatin Market Structure by Size, Valuable Shares, Industry Research, Top Manufacturers, Demand & Forecast Till 2026
Endostatin, a protein, is located in most Basement Membranes (BMs) in the body such as vascular basement membranes. Several research have reported the significant survival benefits of recombinant human endostatin in the treatment of late stage Non-Small-Cell Lung Carcinoma (NSCLC). In September 2005, the State Food and Drug Administration of China (CFDA) approved recombinant human endostatin (Endostar) for the treatment of NSCLC. Endostatin is expressed in various organs, with the highest levels in liver, lung, and kidney.
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Recombinant Human Endostatin Market Drivers
Several governments are focused on reducing the cost of anticancer therapies, which is expected to boost growth of the recombinant human endostatin market during the forecast period. For instance, in August 2018, Government of China took initiatives to reduce prices of anticancer drugs by 44%. Chinese National Health and Family Planning Commission organized a national-wide drug price and reimbursement drug list negotiation, in which a total of 39 products have been successfully added including recombinant human endostatin.
Major institutes are focused on R&D in recognizing potential applications of recombinant human endostatin, which is also expected to boost growth of the market. For instance, according to a paper published in the journal Nature, September 2015, a study was conducted to evaluate effects of recombinant human endostatin in combination with radiotherapy for the treatment of esophageal squamous cell carcinoma and to discover its potential mechanisms. The findings suggested that recombinant human endostatin is a potential anti-angiogenic agent in esophageal squamous cell carcinoma mainly when combined with radiotherapy.
Furthermore, according to National Center for Biotechnology Information (NCBI) January 2017, recombinant human endostatin in combination with Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) may aid in treatment of Angioimmunoblastic T Cell Lymphoma (AITL), a form of Peripheral T Cell Lymphoma (PTCL). Such novel therapies for PTCL treatment are immediately desired to improve the outcomes of patients with this disease. This scenario is expected to contribute to growth of the recombinant human endostatin market.
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Recombinant Human Endostatin Market Restraint
High production of recombinant human endostatin faces several challenges, which are expected to restrict the market growth. For instance, in April 2017, according to a National Center for Biotechnology Information (NCBI) report, tumor treatment needs large quantities of biologically active recombinant human endostatin, which in turn requires production of large quantities of recombinant human endostatin. This process is difficult as it based on recombinant DNA technology and also have low success rates for the treatment of cancer. Furthermore, the cost of recombinant human endostatin is high and it has short half-life. Endostatin is unstable since, endostatin-purification process may denature its structure and the resultant yields may be low.
Recombinant Human Endostatin Market – Regional Analysis
On the basis of region, the global recombinant human endostatin market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. North America is expected to hold dominant position in the global recombinant human endostatin market over the forecast period. This is owing to increasing prevalence of cancer in the U.S. For instance, according to a report by the Centers for Disease Control and Prevention (CDC), around 1,633,390 new cancer cases were reported in the U.S. in 2015 and the number is expected to reach to 1,735,350 in 2018.
The market in Asia Pacific is majorly driven by increasing number of clinical trials for recombinant human endostatin. For instance, the PLA General Hospital in China is undertaking clinical phase II study for recombinant human endostatin combination with radiotherapy for the treatment of Hepatocellular Carcinoma (HCC). The study started in January 2017 and is estimated to complete in December 2019. Moreover, Yun-fei Xia University, in China is undergoing clinical phase II study using chemotherapy and Endostar (endostatin). Endostar is administered as an intravenous infusion for the treatment of refractory nasopharyngeal carcinoma. The study started in July 2015 and is expected to complete in December 2020.
Key players operating in the global recombinant human endostatin market include, Pfizer Inc., Novus Biologicals, Biocon, Thermo Fisher Scientific, Yantai Medgenn Ltd., FUJIFILM KYOWA KIRIN BIOLOGICS Co., Ltd., PeproTech, Inc., Onyx Pharmaceuticals, Inc., Genexine, Inc., Hetero., Intas Pharmaceuticals Ltd., and Novartis AG.
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Recombinant Human Endostatin Market – Taxonomy
- Medical Application
- Scientific Application
- North America
- Asia Pacific
- Latin America
- Middle East
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