HLA Typing Market is Expected to Reach CAGR of 6% by the End of 2030

HLA Typing Market Overview:

The global HLA typing market is expected to expand at a compound annual growth rate (CAGR) of approximately 6% during the forecast period. Market growth is driven by the rising demand for organ and tissue transplantation, continuous advancements in molecular diagnostics—particularly next-generation sequencing (NGS) and PCR-based technologies—expanding applications of HLA typing in infectious disease research, increasing numbers of stem cell and bone marrow transplants, and the growing prevalence of autoimmune disorders and cancers. In addition, greater public awareness and improved organ donation rates worldwide are further supporting market expansion.

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Report Overview

Human leukocyte antigen (HLA) testing, also referred to as HLA or tissue typing, is a genetic diagnostic procedure used to identify antigens present on the surface of cells and tissues. Its primary role is to assess compatibility between transplant donors and recipients, which is critical for minimizing immune-mediated rejection. HLA testing also enables the detection of pre-existing antibodies in transplant recipients that may target donor tissues, directly influencing transplant outcomes. The extent of donor-recipient matching required varies by transplant type, thereby determining the specific HLA genes and testing methodologies employed.

Advancements in molecular diagnostics accelerate HLA typing adoption

Since the introduction of polymerase chain reaction (PCR), DNA-based methods have become the standard in HLA typing laboratories due to their superior accuracy, sensitivity, reproducibility, and resolution. Commonly used techniques include PCR with sequence-specific primers (SSP), sequence-specific oligonucleotides (SSO), real-time PCR, sequencing-based typing (SBT), and next-generation sequencing (NGS).

Among these, NGS—also known as high-throughput sequencing—is increasingly favored as the preferred HLA typing technology. Its ability to deliver high-resolution results with greater speed and throughput, while resolving allele ambiguities at costs comparable to SBT, has significantly enhanced its adoption. NGS workflows involve DNA library preparation, targeted gene amplification using emulsion or solid-phase PCR, sequencing, and alignment against reference databases such as the IMGT/HLA database. Ongoing improvements in sequencing platforms, coupled with artificial intelligence integration, have further enhanced automation, portability, accuracy, and operational efficiency. As diagnostic technologies advance, the combined use of qPCR and NGS is becoming increasingly critical to address the growing demand for precision and personalized medicine, particularly in oncology, where rapid and accurate genetic insights can directly inform treatment decisions.

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Rising organ transplantation demand fuels market growth

According to data from the World Health Organization (WHO), the Global Observatory on Donation and Transplantation (GODT), and the Organización Nacional de Trasplantes (ONT), global organ donation and transplantation activity continues to rise. The 2023 International Report on Organ Donation and Transplantation reported a 9.5% year-on-year increase in solid organ transplants, reaching 172,397 procedures worldwide. This growth is largely attributed to the increasing burden of end-stage organ failure, including kidney, liver, heart, and lung diseases. Chronic conditions such as diabetes, hypertension, and cardiovascular disorders remain major contributors to kidney failure, while hepatitis, cirrhosis, and alcohol-related liver disease continue to drive demand for liver transplantation.

As transplant volumes increase, accurate donor-recipient matching has become more critical than ever. HLA typing plays a central role in improving transplant outcomes by reducing rejection risk and enhancing long-term graft survival. High-precision HLA typing is particularly vital in kidney, bone marrow, liver, and heart transplants, where compatibility significantly affects success rates. Consequently, the growing need for organ and tissue transplantation is directly driving demand for advanced HLA typing solutions.

Competitive Landscape Analysis

The global HLA typing market comprises a mix of established and emerging players, including Thermo Fisher Scientific Inc., Bio-Rad Laboratories Inc., QIAGEN N.V., Omixon Inc., GenDx, Illumina Inc., TBG Diagnostics Limited, Becton, Dickinson and Company, Takara Bio Inc., F. Hoffmann-La Roche Ltd., Pacific Biosciences, Immucor, Inc., and CareDx, Inc., among others. Key competitive strategies adopted by these companies include new product launches, strategic partnerships and collaborations, and continued investment in research and development to strengthen technological capabilities and market presence.

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Market Segmentation

This report by Medi-Tech Insights provides the size of the global HLA typing market at the regional and country levels from 2023 to 2030. The report further segments the market based on technology, product and service, application, and end user.

• Market Size & Forecast (2023-2030), By Technology, USD Million
  • Molecular Assay
    • PCR
    • Next Generation Sequencing
  • Non-Molecular Assay
• Market Size & Forecast (2023-2030), By Product & Service, USD Million
  • Reagents & Consumables
  • Instruments
  • Software & Services
• Market Size & Forecast (2023-2030), By Application, USD Million
  • Diagnostic Applications
    • Donor-Recipient Cross-Matching
    • Infectious Disease Testing
    • Cancer Diagnosis & Prevention
    • Transfusion Therapy
    • Other Diagnostic Applications
  • Research Applications
• Market Size & Forecast (2023-2030), By End User, USD Million
  • Commercial Service Providers
  • Hospitals & Surgical Centers
  • Research Laboratories & Academic Institutes
• Market Size & Forecast (2023-2030), By Region, USD Million
  • North America
    • US
    • Canada
  • Europe
    • UK
    • Germany
    • France
    • Italy
    • Spain
    • Rest of Europe
  • Asia Pacific
    • China
    • India
    • Japan
    • Rest of Asia Pacific
  • Latin America
  • Middle East & Africa

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