Almanac Health Raises $10 Million to Empower Clinicians Across Specialties with Safe, Research-Validated Clinical AI

Seed round led by F-Prime, with participation from General Catalyst and Lightspeed Venture Partners. General Catalyst previously led the pre-seed round.

BOSTON--(BUSINESS WIRE)--Almanac Health, a research-validated clinical AI platform and evidence-based clinical decision support company founded by physician-researcher Cyril Zakka, MD, whose work at Stanford introduced retrieval-augmented generation to clinical medicine, has raised $10 million in a seed round led by F-Prime, with participation from General Catalyst and Lightspeed Venture Partners. General Catalyst previously led the company’s pre-seed round with participation from Soma Capital. This financing brings Almanac Health’s total funding to nearly $12 million and will accelerate the company’s mission to bring safe, evidence-grounded AI to clinicians and health systems.

Almanac Health is a unified clinical AI platform for clinical decision support that brings specialist-grade knowledge to every clinician at the point of care. It is designed to work within existing electronic health record (EHR) systems, governed by institutional controls, and grounded in peer-reviewed evidence. The platform is currently undergoing rigorous clinical validation in academic medical center settings.

“There is no shortage of technologies promising to transform medicine. But few are grounded in real evidence, built with integrity and deserving of trust from the people and organizations using them. Almanac Health’s goal is to build clinical AI held to that standard. Validated through research, with incentives aligned with clinicians and patients. We’re focused on getting that right,” said Cyril Zakka, MD, founder and CEO of Almanac Health.

Cyril Zakka, MD has worked at the intersection of medicine and AI across clinical practice, academic research, and industry. After earning his MD, he went on to conduct machine learning research at Stanford, where he developed the first retrieval-augmented generation system for clinical medicine, an approach to grounding AI in trusted medical knowledge that has since been widely adopted across clinical AI. That work, published in NEJM AI, became one of the journal’s most-cited papers and established the foundational approach used by most clinical evidence AI products today. He subsequently led health AI at Hugging Face, the largest open-source AI platform, before founding Almanac Health.

“Cyril is one of the rare founders who has both the clinical training and the technical depth to build AI that clinicians will actually trust as well as the discipline to validate it before deploying it. Almanac Health represents what we believe the next generation of healthcare AI should look like: grounded in research, governed by institutions, and built with incentives that put clinicians and patients first,” said Carl Byers, Partner at F-Prime.

The funding will allow the company to grow its team across clinical medicine, AI research, and health systems infrastructure, as well as advance R&D with a focus on privacy, reliability, and rigorous evaluation before deployment.

“We believe the next generation of healthcare infrastructure will be defined by how effectively it translates frontier intelligence into everyday clinical decisions. Almanac is doing exactly that: building a physician-centric platform that brings trusted, evidence-based intelligence into the workflow, with the alignment and accountability required for true health assurance,” said Alexandre Momeni, Partner at General Catalyst.

Almanac Health is hiring across engineering, AI research, and clinical development. Interested candidates can contact cyril@almanac.chat or visit https://almanac.chat/.

Clinicians and health system leaders interested in early access to Almanac Health can reach the team at support@almanac.chat.

About Almanac Health

Almanac Health is a clinical AI platform that brings specialist-grade knowledge to clinicians at the point of care, providing evidence-based clinical decision support across medical specialties, free from pharmaceutical advertising, and governed by institutional controls. The platform integrates with existing EHR systems and is clinically validated through peer-reviewed research. Almanac Health was founded by Cyril Zakka, MD, author of one of NEJM AI’s most-cited papers on retrieval-augmented generation for clinical medicine, and is backed by F-Prime, General Catalyst, and Lightspeed Venture Partners. For more information, visit https://almanac.chat/.

Media Contact: press@almanac.chat