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Amygdala Neurosciences Acquires GS-6637 from Gilead Sciences

17 Feb 17

Amygdala Neurosciences Inc., a biopharmaceutical company focused on the development and commercialization of first-in-class drug candidates for addiction disorders, has entered into an agreement with Gilead Sciences, Inc. for the acquisition of GS-6637, a highly selective ALDH2 inhibitor with the potential to treat behavior and substance addictions based on a mechanism of action that prevents pathophysiologic dopamine surges and associated craving without changes to basal dopamine.  

"Completion of this transaction launches Amygdala Neurosciences with a Phase-2 ready asset that we believe has the potential to become a treatment for addiction," said Peter Strumph, Amygdala's co-founder and CEO. "In 2017, we look forward to initiating clinical trials for the treatment of both cocaine and alcohol use disorders."

"Preventing relapse is a critical treatment objective. When exposed to stimuli associated with drug use, addicts experience a pathophysiologic dopamine surge that leads to craving and promotes drug relapse," said Ivan Diamond, MD, PhD, and Amygdala's co-founder and CSO. "In animal studies, GS-6637 decreased drug use and relapse by preventing the stimuli induced pathophysiologic dopamine surges which result in craving and drug seeking behavior."

About GS-6637
GS-6637 is a Phase-2 ready compound that utilizes a novel pathway for the treatment of addiction. GS-6637 is highly selective ALDH2 inhibitor that modifies dopaminergic tone by preventing pathophysiologic dopamine surges and associated craving without changes to basal dopamine. This profile, which prevents craving and drug seeking behavior, has the potential to be used as a pharmacotherapy for substance and behavior and based addictions.

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