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DESCRIPTION:The ubiquitin-proteasome\, lysosome and autophagy systems are 
 all well-controlled\, selective degradation pathways that are key cellula
 r regulators in cancer\, CNS and other diseases. A new generation of hete
 ro bi-functional chimeras and small molecule monovalent degraders are bei
 ng developed to hijack these systems for targeted protein degradation or 
 stabilization. These molecules that include Proteolysis-targeting chimera
 s (PROTACs) and molecular glues are being used to seek out previously &am
 p\;amp\;ldquo\;undruggable&amp\;amp\;rdquo\; targets for therapeutic inte
 rvention. However\, challenges do exist in terms of specificity\, stabili
 ty\, biodistribution and penetration of these degrader molecules.\n\nThe 
 2nd Annual conference on Next-Generation Degraders &amp\;amp\; Glues brin
 gs together experts in the field to discuss these new therapeutic modalit
 ies\, as well as issues underlying the use of targeted degradation as a n
 ew therapeutic approach.\n
DTEND:20230622T040400
DTSTAMP:20260514T145939Z
DTSTART:20230620T103000
LOCATION:South Quay\, Marsh Wall\, London\, Greater London\, E14 9SH\,
SEQUENCE:0
SUMMARY:The ubiquitin-proteasome\, lysosome and autophagy systems are all 
 well-controlled\, selective degradation pathways that are key cellular re
 gulators i...
UID:e1b784ec-7f69-4359-80c1-2515a45a6008
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