BEGIN:VCALENDAR
PRODID:-//github.com/rianjs/ical.net//NONSGML ical.net 4.0//EN
VERSION:2.0
BEGIN:VEVENT
DESCRIPTION:This is online short course will look at biocatalysed/biotrans
 formation reactions to make pharma/agrochem chem intermediates\, API’s an
 d fine chemicals. the focus is on scale-up issues and getting productive 
 process established.\n\nJune 17th\, 1.30 – 4.30 pm (UK) | Session 1\n\nJu
 ne 18th\, 1.30 – 4.30 pm (UK) | Session 2\n\nMany forays by organic chemi
 sts into using biocatalysis in chemical synthesis stall at the initial sc
 ale-up stage. Screening and small scale (gram) reactions progress as plan
 ned\, but when scaled -up\, reactions stall\, take more enzyme than expec
 ted\, work-ups end up with emulsion issues etc. This course will look at 
 some of the techniques and technologies ( tricks of the trade) that can h
 elp derisk scaling up biocatalysed reactions .A further barrier to the ad
 option of more biocatalytic reactions are production / EHS scientists who
  are unsure how to handle enzymes in the plant/pilot plant. the course wi
 ll also look at good sources of information/data to facilitate the use of
  enzymes at scale.\n\nEnzyme supply chain: Storage\, stability etcTechno-
 economic analysis – will the transformation ever hit the required targets
 ?Different types of strains used and its safety impactions.Using GMO’s an
 d GMO derived materialsHandling concerns related to enzyme -SHE/EHS issue
 s.\, Safety issues in scaling up biocatalytic reactionsPros and cons of d
 ifferent enzyme formulationsEnzyme stability: General to pH\, co-solvent\
 , temperature as linked to process design and developmentEnzyme analysis 
 / characterisation – needed to assess purity in order to calculate activi
 ty and so expected long term cost\, spec setting / quality control (ensur
 e plant samples match lab samples and measure variation over time).Scale-
 up – reactor options – various reactor types\, std batch\, continuous\, m
 embrane separated\, continuous liquid extraction\, etcProduct isolation f
 rom complex mix . Enzyme removal/ downstream processing– to be intelligen
 t in terms of what can and can’t be removed vs effects on process includi
 ng downstream chemistry.Use of immobilised enzymes/ Recycling of immobili
 sed enzymesSome IP considerations\n\n&nbsp\;\n\nTime: 1:30 PM - 4:30 PM\n
DTEND:20240618T163000
DTSTAMP:20260512T230904Z
DTSTART:20240617T133000
LOCATION:Online\, Event\, Crowborough\, East Sussex\, TN6 1DH\,
SEQUENCE:0
SUMMARY:This is online short course will look at biocatalysed/biotransform
 ation reactions to make pharma/agrochem chem intermediates\, API’s and fi
 ne chemic...
UID:2028c7eb-f5c2-4bda-a0b2-d673da9f2d11
END:VEVENT
END:VCALENDAR