BEGIN:VCALENDAR PRODID:-//github.com/rianjs/ical.net//NONSGML ical.net 4.0//EN VERSION:2.0 BEGIN:VEVENT DESCRIPTION:Session DescriptionVisualizing the extracellular matrix (ECM) in real-time has long been a challenge. Dr. Kayvon Pedra’s group has deve loped a novel\, cell-impermeant fluorophore that red-shifts and activates upon binding glycans. This allows for seamless\, wash-free imaging of gl ycosylated ECM architecture—from in vitro models to in vivo mouse tumors— providing a powerful new tool for live fluorescence microscopy.\n\nHighli ghts of the presentationA cell-impermeable small molecule fluorophore tur ns on and red-shifts upon binding glycosylated biomolecules.Application o f the dye to live biological samples enables wash-free visualization of e xtracellular matrix structure.Observations demonstrate no toxicity\, a br oad substrate profile\, deep tissue penetration\, and negligible photoble aching in a variety of model organisms.\n\nWebinar SpeakerDr. Kayvon Pedr amGroup Leader at HHMI's Janelia Research CampusKayvon is a Group Leader at HHMI's Janelia Research Campus near Washington\, D.C. He received his bachelor's degree in 2015 from MIT working with Prof. Alice Ting and his Ph.D. in 2021 from Stanford working with Prof. Carolyn Bertozzi. The Pedr am Lab\, established in 2021\, aims to discover principles by which extra cellular assemblies govern mammalian biology across spatial scales\, deve lop therapies that take advantage of the unique and underexplored propert ies of extracellular biomolecules\, and widely distribute methods that wi ll allow others to join those long-term efforts. For more information\, s ee https://pedramlab.com.\n\nPlease note this is an online event! Registe r first: https://www.bocsci.com/webinar-live-imaging-of-the-extracellular -matrix-with-a-glycan-binding-fluorophore.html\n\n\n \;\n DTEND:20260609T110000 DTSTAMP:20260512T213554Z DTSTART:20260609T100000 LOCATION:\, SEQUENCE:0 SUMMARY:Session DescriptionVisualizing the extracellular matrix (ECM) in r eal-time has long been a challenge. Dr. Kayvon Pedra’s group has develope d a nove... UID:e5103d8f-9f93-4e40-9170-b7b4b9f5b73c END:VEVENT END:VCALENDAR