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pharmiweb.com today | 25 August 2016

Novartis announces positive phase III results showing efficacy of BAF312 in patients with secondary progressive MS

Novartis today announced the Phase III EXPAND study, evaluating the efficacy and safety of oral, once-daily, BAF312 (siponimod) in secondary progressive multiple sclerosis (SPMS), met its primary endpoint of a reduction in the risk of disability progression, compared with placebo. The EXPAND study represents the largest randomized, controlled study in SPMS to date.[1]

"SPMS is a particularly disabling form of MS, and there is a need for effective treatment options to helpdelay disability progression in those living with the condition," said Vasant Narasimhan, Global Head of Drug Development and Chief Medical Officer for Novartis. "The positive EXPAND data are encouraging for a disease with such a high unmet need. We look forward to sharing the results at the upcoming ECTRIMS congress, and thank all of the study participants and investigators."...

Topline results of the EXPAND study, including primary and key secondary endpoints, will be presented as a late breaking oral abstract at the 32 nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), September 17 th , in London, UK. Novartis will complete full analyses of the data and evaluate next steps in consultation with health authorities.

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