Global Cytometry Market: Addressing the Barriers to Cell Cytometry Adoption in the Market

In both Allogeneic and Autologous cell therapy products, cell cytometry helps to evaluate key drug parameters that help to understand the effectiveness of the drug delivered to the patient. It has become a revolutionizing tool for the identification and analysis of cell characteristics, cell cycle analysis, hematological studies, and proliferation assays. Despite its significance, the complexity of the cytometry techniques and lack of standard references emerge as a key challenge for the pharmaceuticals to adopt this assay as quality control equipment during drug validation. The conventional cytometry technology is insufficient to handle large data sampling and processing software. To overcome challenges, several researches are ongoing to bring advanced cytometry technology that can help to boost the analysis process. Driven by the factors above, it is expected that the global cell cytometry market is expected to grow at a CAGR of 9.9% in the future, according to Roots Analysis.

Cell Cytometry And Its Applications in Biological Research

Cell cytometry serves as a visualization tool that helps in measuring cell size, cell morphology, cell count, cell cycle phase, and presence/absence of specific proteins on the surface of the cells. The study of cell characterization helps in drug development, specifically target-specific therapeutics for the treatment of chronic disease. The major application of cytometry in modern clinical research settings for research-oriented tasks includes:

• Protein expression: Cell cytometry completes cell analysis and even the nucleus to understand protein expression.
• RNA Analysis: It helps in the analysis of mRNA and miRNA transcripts.
• Cell Cycle Status: cytometry is a tech-driven tool to assess the cell cycle status in G0/G1 phases vs G2, S phase, and polyploidy, as well as detailed analysis of activation and cell proliferation.
• Protein Post Translational Modifications: cytometry helps to analyze the presence of phosphorylated proteins and cleaved proteins.

Types of Cell Cytometry

Some of the common type of cell cytometry use in the clinical applications for cell analysis includes:

1. Image Cytometry

The techniques involve optical microscopy to image a large number of cells. Prior to cytometry, cells were labeled with fluorochromes to detect specific molecules on the basis of color imparting when they pass through optical microscopy.

1. Flow Cytometry

It is a laser-based technology commonly used for the analysis of physical and chemical characteristics of cells and their particles. Flow cytometry is widely accepted to evaluate the peripheral blood, bone marrow, and other body fluids present in the body.

Common Barriers to Wide-Scale Adoption of Cell Cytometry

Though cell cytometry provides valuable insight into immune phenotyping information, it does possess some limitations. The conventional cytometry approach provides a low amount of information, which is not sufficient for the confirmation of disease or malignancy of the tumor—thereby causing a problem in detection and treatment. Pharmaceutical companies may be constrained to adopting cell cytometry on a large scale because of the following issues:

• Fresh Sample Requirement

cytometry requires fresh samples because previously stored samples can result in natural apoptosis of the cells, which further affects the specificity of the analysis of the cells through cytometry. Moreover, cell cytometry cannot be done on formalin-fixed tissues as it leads to false results because of the chemical hindrance. The cellular debris and apoptotic cells also result in non-specificity antibody adsorption—leading to the generation of false positives. Flow cytometry companies may or may not rely on the conventional method as it lacks the cell morphological correlation. Sampling problems such as haemo-diluted bone marrow aspirates and particulates can influence the flow of cytometry results.

• Complex Technology

Cell cytometry is a complex technology; an appropriate technology is required to generate efficient results. For instance, gating on CD34 versus SSC is frequently used to estimate the blast lymphocyte population in presumptive acute leukemia, yet some acute leukemia is CD34 negative. The use of expired or contaminated reagents can also cause problems in calculating final results. Therefore, companies have to focus on leveraging advance technology to get appropriate analysis results.

• Low Throughput

The conventional cytometry methods are unable to handle a large amount of samples because they lack advanced data processing software. Therefore, multiple cycles have to be run by researchers to get maximum output, which can be a cost endeavor. To overcome the challenge, the cell cytometry market is shifting towards high throughput cell cytometers. The trend of using high throughput flow cytometry methods changes the future market scenario and is expected to grow at a steady rate.

Cell Cytometry Current Market Landscape and Developments

Novel cell cytometry is a crucial visualization tool that is used for cell sorting, cell proliferation assays, biological sample analysis, characterization, and hematological studies. However, due to limited throughput and complex software, the cell cytometry market has witnessed an increase in the demand for the latest technological cell analyzers that are capable of handling large amounts of samples and identification of potent biomarkers. Moreover, the adoption of flow cytometry methods and image cytometry in numerous research applications such as cytogenomics, proteomics, and oncology research further accelerated the cell cytometry market. Several research studies have taken place in the cytometry field, such as 3D printing and others—some of the recent developments are as follows:

• In July 2023, Desktop Health entered into a partnership with Carbon in order to validate the Flexacera Smile Ultra+ to utilize the Carbon Digital manufacturing platform and to gain access to nanoceramic resin in high-volume dental labs.
• In May 2023, HP Multi Jet Fusion collaborated with Metal JET with the aim of expanding the medical 3D printing potential by combining Metal Jet S100 systems and Jet Fusion 5420W.

Who Are the Top Cell cytometry Market Players?

Some of the key cell cytometry market players who are actively looking for high throughput flow cytometry solutions include:

• Agilent
• Beckton Dickinson
• Beckman Coulter Life Sciences
• Bio-Rad
• Chemometec
• Milkotronic
• Nexcelom Bioscience
• Sartorius
• Sony Biotechnology
• ThermoFisher Scientific
• Union Biometrica.

Promising Future of Cell cytometry

With increasing pressure on pharmaceuticals to find innovative solutions for cell isolation and identification, the cell cytometry market is looking forward to developing advanced solutions, including 3D printing and high throughput cytometry, to help researchers identify and characterize cells more effectively.

About Roots Analysis

Roots Analysis is a global leader in the pharma/biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists, and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights. All reports provided by us are structured in a way that enables the reader to develop a thorough perspective on the given subject. Apart from writing reports on identified areas, we provide bespoke research/consulting services dedicated to serving our clients in the best possible way.