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Enzymes have a variety of applications including technical applications, food manufacturing, animal nutrition, cosmetics, pharmaceuticals, and research and development tools.
Enzymes are protein molecules that act as specific catalysts for chemical reactions. Researchers have made significant contributions to the traditional and modern chemical industries by improving existing processes. Representative industrial applications of enzymes are concentrated in the fields of technology applications, feed industry, food processing and cosmetics. Enzymes are natural catalysts. They are produced by living organisms to increase the speed of the enormous and diverse learning reactions required for life. They involve all processes necessary for life, such as DNA replication and transcription, protein…
Resistance to anticancer drugs results from a variety of factors, and individual genetic difference is just one of them. This article is about how to overcome drug resistance against KRAS inhibitors in cancer treatment.
Recently, KRAS and KRAS-G12C mutant inhibitors, which were previously considered to be "non-drugable" targets, have ignited a development boom. However, KRAS inhibitors are not a "magic bullet" for once and for all. Drug resistance is a major problem that frequently occurs in cancer treatment. In clinical practice, tumor tissue becomes significantly smaller after targeted therapy, but soon deteriorates again. Such scenes are commonly observed in real situations. Amgen's latest clinical trial results also indicate that some patients treated with the KRAS-G12C inhibitor AMG 51…
The severe side effects of conventional chemotherapeutic treatments can’t be ignored since in most cases, the valid drug dose that can remove the tumor are too toxic for patients. To solve the limitations, the antibody drug conjugates (ADCs) have emerged consisting of tumor-selective antibody-linked drugs, with the potential to significantly broaden the therapeutic range.
The severe side effects of conventional chemotherapeutic treatments can’t be ignored since in most cases, the valid drug dose that can remove the tumor are too toxic for patients. To solve the limitations, the antibody drug conjugates (ADCs) have emerged consisting of tumor-selective antibody-linked drugs, with the potential to significantly broaden the therapeutic range.   Antibody-drug conjugates (ADCs), the focus o…
Dr. Dennise Broderick, President and Managing Director of global speciality pharmaceutical company, Galen, was the first member to participate in Northern Ireland Chamber of Commerce and Industry’s CEO Spotlight Series.
Craigavon, N.I., 7 Oct 2019 - Dr. Dennise Broderick, President and Managing Director of global speciality pharmaceutical company, Galen, was the first member to participate in Northern Ireland Chamber of Commerce and Industry’s CEO Spotlight Series. Supported by KPMG, the series, which was formally launched on Thursday 3rd October, aims to inspire business growth in local companies through exchanging leadership stories of successful entrepreneurs and senior managers. The inaugural event took place at KPMG’s Soloist Building in Belfast and consisted of a business breakfast fe…
Enzymes, in other words, are just proteins. Since there are only a lot of enzymes for industrial use in the future, it is known that the future development and optimization of catalytic proteins is essential. So what is enzymes development and optimization?
The interpretation of enzymes in the modern industry certainly does not refer to yeast, but to proteins with catalytic functions. As a natural catalyst, enzymes promote various chemical reactions in cells and play a vital role in the existence of living organisms. From the concept of enzymes, to the mature industrial enzyme production, it has probably gone through 130-40 years. The Greek translation of the enzyme is "in yeast", meaning from yeast. In 1897, after the methods of disruption for yeast, the extract obtained had the…
This is why, in 2017, colored display monitors held a 68.5% revenue share in the medical display monitor market. On the basis of panel size, the market is divided into displays under 22.9 inch, 23.0–26.9 inch, 27.0–41.9 inch, and above 42.0 inch. Out of these, during the 2013–2017 period, the 23.0–26.9 inch division exhibited a CAGR of 3.9%, which is anticipated to surge to 5.4% during 2018–2023.
The growth of the global medical display monitor market is mainly driven by the rising incidents of chronic diseases, increasing usage of hybrid operating room (OR) technologies, surging demand for minimally invasive treatments, and availability of advanced monitors. In 2017, the market attained a size of $2.1 billion, and it is predicted to witness a CAGR of 4.9% during the forecast period (2018–…
Healthcare Mobility Solutions Competitive Trend Analysis By Product and Service Type mobile devices, mobile apps, and enterprise mobility platform), By Application mHealth, enterprise mobility management, and others
Healthcare Mobility Solutions Market Research By Product and Service Type (mobile devices, mobile apps, and enterprise mobility platform), By Application (mHealth, enterprise mobility management, and others), By End Users (hospital/clinics, laboratories, patients and others) - Forecast to 2022 Healthcare mobility solutions market is growing rapidly post 2016 with the CAGR of ~24%, thus growth period of this market can be stated as from 2017-2022. According to a recent study report published by the Market Research Future, the global healthcare mobility solutions market is booming…
North America Dental Equipment Market Research Report By Product (Dental Radiology Equipment, Dental Hand Pieces, CAD/CAM), Application (Examining The Mouth & Teeth, Cavity Removal, Condensing Filling Materials), End User –  Forecast To 2023
North American Dental Equipment Market Overview Over the last two hundred years, dentistry has made countless strides and also experienced a few setbacks globally. Though, the ultimate goal of the profession has always remained the same, which is to meet the treatment needs of the patient. Dental technology remains an important and valuable key to providing excellence in patient care. The role of today’s dental specialist has extended and evolved to being a gatekeeper of new product information, advisor on new restorative materials, imaging devices and…
Compared to polyclonal antibodies, monoclonal antibodies have multiple advantages, featured by strong specificity for a single epitope, little or no variability, and the easy operation to modify and customize in terms of different needs, thereby turning out to be the most suitable candidate for recombinant antibodies (rAbs). The rAbs are obtained through sequencing of the animal's immune cells and inserting the gene into a suitable cell strain, such as bacterium, yeast, and mammalian cells. Even if the original cell strain dies or is mutated, the desired cell strain can be generated by gene insertion since the antibody is definitive.
In general, polyclonal antibodies are made by collecting blood from an immunized animal stimulated with a target antigen, which can be provided all the time as…
Bispecific antibody (BsAb) is an artificially engineered antibody that can simultaneously bind two specific epitopes or target proteins with some special biological functions, such as directly targeting effector cells to tumor cells, to enhance cytotoxicity, improve antibody selectivity and functionality, and avoid immune escape mechanisms, thereby improving therapeutic efficacy. BsAb also reduces the cost of drug development and clinical trials compared to the combination of two monoclonal antibody drugs.
Bispecific antibody (BsAb) is an artificially engineered antibody that can simultaneously bind two specific epitopes or target proteins with some special biological functions, such as directly targeting effector cells to tumor cells, to enhance cytotoxicity, improve antibody selectivity a…
The human insulin (HI) market size is predicted to reach $70.6 billion by 2023, according to P&S Intelligence.
On account of the growing number of diabetic patients, increasing geriatric population, technological advancements in insulin delivery devices, and rising population exposed to risk factors are leading to the growth of the human insulin market. The global market generated a revenue of $42.9 billion in 2017, and it is expected to witness a CAGR of 8.8% during the forecast period (2018–2023). Human insulin (HI) is synthetic insulin, which mimics the effects and functionality of natural insulin in humans. It is generally created by growing the insulin protein in the E. coli bacteria. In a recent P&S Intelligence research, the human insulin market is segmented by type, application,…
Global ADHD Therapeutics Information, by drug types (Stimulants and Non-stimulants), by distribution channels (hospitals, clinics, pharmacies, research laboratories and others) - Forecast to 2024
Attention Deficit Hyperactivity Disorder (ADHD) Market Highlight Attention Deficit Hyperactivity Disorder (ADHD), a neuro-developmental condition mostly occurs in childhood. However, if not appropriately treated in time, the disorder continues in adulthood as well. Patients, suffering from ADHD show symptoms of tenacious issues, such as impulsive behavior, difficulty in sustaining attention, and hyperactivity, etc. The exact cause leading to ADHD is still not known. However, prenatal tobacco exposure, premature birth, and genetics are some of the environmental factors considered as major risk fac…
Investment in biotechnology has been on the rise for nearly a decade, with biotech startups raising just shy of 29 billion USD in 2018. For smart investors, due diligence is now a necessity, as it can make the difference between landing a possible billion-dollar blockbuster or a multi-million dollar dud.
In recent years the biotech and pharmaceutical industries have seen an unprecedented increase in investment. Both large pharma and investors are all searching for the next big thing to expand their portfolios and continue growth. Risk is high and a key part of mitigating this is effective due diligence. Simply put, due diligence is the investigation of a business or asset prior to signing a contract. As with any transaction, information is never perfect and the concept is that by conducting…
Enzymes, as a biologically active catalyst, also have some special properties compared to other industrial catalysts. Understanding these characteristics is of great significance for us to understand enzymes, and better utilize enzymes for industrial use and production.
Cellular activity carrying out in the living body depends on different chemical reactions. If there is no enzyme, then the body's metabolism and other life-related reactions can only be carried out at an extremely slow rate. Under such circumstances, life activities cannot be maintained. Scientists predict that if there is no enzyme, the body temperature needs to reach about 300 °C to digest food.   The human body may lack certain enzymes for some reasons, causing the reaction catalyzed by the enzyme to be abnormal, and…
More than 2,000 enzymes have been identified, and each enzyme is involved with one specific chemical reaction. Enzymes are therefore substrate-specific. They are grouped into a half-dozen classes on the basis of the kinds of reactions they take part in.
Enzymes are key protein molecules in living systems. Once synthesized, they are not usually converted to other kinds of molecules, and so are the substances taken in as fuel for digestive and respiratory processes (such as sugar, fat, and molecular oxygen). This is because enzymes are catalysts, which means they can participate in chemical reactions without themselves being changed, just like the moderator of a public debate who ideally moves the participants and the audience toward a conclusion by dictating the terms of the argument while n…
Here are the top Pharma and Life Science recruitment organisations advertising in September on PharmiWeb.jobs.
Barrington James Clinical - 206 Jobs RBW Consulting - 163 Jobs i-Pharm Consulting - 141 Jobs CHASE - 133 Jobs SEC Recruitment - 116 Jobs ID Search & Selection - 86 Jobs Clinical Professionals Ltd - 85 Jobs Hobson Prior - 76 Jobs CK Clinical - 68 Jobs Barrington James Europe - 63 Jobs X4 Life Sciences - 63 Jobs Advanced Regulatory (UK & Europe) - 60 Jobs Barrington James Medical / Executive - 58 Jobs Thornshaw Recruitment - 56 Jobs Barrington James Scientific - 48 Jobs Only Medics Recruitment ltd - 46 Jobs Planet Pharma Staffing Limited - 45 Jobs Umbilical Life - 44 Jobs ProClinical Ltd - 39 Jobs CTC Resourcing Solutions - 34 Jobs Volt - 31 Jobs Haybury - 31 Jobs Advanced S…
A list of the TOP Pharma Companies who are hiring this month (September)
Covance - 388 Jobs BSI Group - 167 Jobs PRA Health Sciences - 105 Jobs PPD- 81 Jobs Roche - 77 Jobs Synteract- 74 Jobs United BioSource Corporation. - 69 Jobs Cytel - 68 Jobs Syneos Health - 52 Jobs CROMSOURCE - 51 Jobs IQVIA - 36 Jobs AstraZeneca - 36 Jobs Celgene - 32 Jobs IQVIA Biotech - 21 Jobs Oxford BioMedica (UK) Limited - 16 Jobs Lonza - 16 Jobs Grunenthal GmbH - 14 Jobs   Register and Upload Your CV Now