PharmiWeb.com - Global Pharma News & Resources

Articles

In-house legal teams are an indispensable resource to a business, especially in heavily IP-driven sectors such as life sciences and pharmaceuticals. The current economic choppy waters mean having talented legal brains in the boardroom to tackle a range of business-critical decisions is more important than ever. However, against this challenging backdrop, how can pharma companies compete with the pay wars being waged by law firms to lure talented lawyers in-house?
In-house legal teams are an indispensable resource to a business, especially in heavily IP-driven sectors such as life sciences and pharmaceuticals. The current economic choppy waters mean having talented legal brains in the boardroom to tackle a range of business-critical decisions is more important than ever. However, against thi…
Whole genome sequencing (WGS) has the capacity to greatly enhance genomic knowledge and understand mysteries of life by utilizing the most advanced genetic sequencing technologies. WGS can be used for variant calling, genome annotation, phylogenetic analysis, reference genome construction, and more. WGS tries to cover the whole genome, but actually covers 95% of the genome with technical difficulties in sequencing regions such as centromeres and telomeres. Another challenge for WGS is data management. As larger datasets become more accessible and affordable, computational analysis will be the rate-limiting factor rather than sequencing technology. Here we will discuss the bioinformatics workflow for detection of genetic variations in WGS to help you get through it.
Whole genome sequencing (…
Decentralisation allows for more diverse patient participation and improved data collection, leading to faster, more accurate results in clinical trials.
With the emergence of COVID-19, Decentralisation of Clinical Trials became necessary to comply with social distancing requirements while carrying out clinical research. Over the past few years, the clinical trial landscape has shifted its focus to patient-centric practices to promote patient engagement. But now as the pandemic is long gone, it is time to reflect on how DCT studies are genuinely addressing long-standing issues in research and development for sponsors, study teams, and of course, the patients! The digital shift in clinical trials has brought about the potential to improve both patient experience and clinical data quality si…
Chronic Obstructive Pulmonary Disease, or COPD, has been branded as the "silent killer." It is because some people do not even know they have it until it becomes too dangerous to handle. Millions of people in the United States have COPD but have not been diagnosed because they are unaware of it. This implies that they also do not get treatment for it. This is when the disease becomes a threat to life. Let us first learn more about COPD.
Chronic Obstructive Pulmonary Disease, or COPD, has been branded as the "silent killer." It is because some people do not even know they have it until it becomes too dangerous to handle. Millions of people in the United States have COPD but have not been diagnosed because they are unaware of it. This implies that they also do not get treatment for it. This i…
Carbon nanomaterials have been speedily developed due to their unique electronic, optical, thermal, mechanical, and chemical nature.
History of Development As early as 1985, the discovery of fullerene with the “football” structure immediately attracted the world’s attention. Then, carbon nanotubes with a hollow cylindrical structure are formed based on mild modifications toward fullerenes. In 1991, Japanese researchers discovered carbon nanotubes in carbon fibers for the first time. In 2004, researchers discovered the 2D planar nanomaterial whose planar thickness is confined to the nanoscale range. At the same time, researchers also developed a practical “scotch tape” technique to separate single-layer graphene from bulk graphene. Buckyballs (fullerenes), carbon nanotubes, and graphene all…
Clinical Research Associates (CRA) are responsible for organising and monitoring clinical trials, helping to identify the benefits and risks of new and pre-existing drugs, ensuring they’re effective and safe for their intended use. CRAs are often involved in all stages of a clinical trial, from identifying a relevant investigational site and setting up the trial, to closing down the trial and preparing final reports.
Clinical Research Associates (CRA) are responsible for organising and monitoring clinical trials, helping to identify the benefits and risks of new and pre-existing drugs, ensuring they’re effective and safe for their intended use. CRAs are often involved in all stages of a clinical trial, from identifying a relevant investigational site and setting up the trial, to closing dow…
Bachem is a leading, innovation-driven company specialising in the development and manufacture of peptides and oligonucleotides. With 50 years of experience, Bachem provides products for research, clinical development and commercial application to pharmaceutical and biotechnology companies worldwide and offers a comprehensive range of services. Bachem operates internationally, with headquarters in Switzerland and locations in Europe, the US and Asia. The company is listed on the SIX Swiss Exchange.
Oligonucleotides are short, single or double-stranded fragments of DNA or RNA that can be used for therapeutic purposes. Originally, there was an emphasis on using this new drug modality for treating rare diseases, yet they have also shown great potential to be used for more common diseases. …
ICH Q3D presents major challenges to testing and risk assessments associated with meeting current rigorous limits for specific components to assess patient risk. The probability that sure elemental impurities area unit gift in a very healthful product ought to be determined through a legitimate risk assessment.
The mission of the International Council for Harmonisation of Technical needs for prescription drugs for Human Use (ICH) is to make sure safe, effective, and high-quality medicines area units are developed and distributed. This is often accomplished by making worldwide harmonization. Harmonization achievements within the quality space include: Essential milestones like the conduct of stability studies Process relevant thresholds for impurities testing A lot of versatile approaches t…
The biotech industry is a large and growing field with many opportunities for those who want to pursue it professionally. The growth of this industry has been rapid in recent years, with more than 200 new products being marketed every year. In this article, we will look at the current trends in the industry and discuss how they affect marketers and consumers.
What is Biotechnology? Biotechnology is the application of biological processes and materials, including biochemistry, microbiology and molecular biology. Nobel-prize-winning chemist George Wald coined the term in 1949. Biotechnology is not the same as traditional biochemistry: it encompasses a diverse range of techniques we can use for industrial processing and research purposes. For example, it includes processes such as recombin…
Lung cancer is a major type of cancer in the world, with the highest morbidity and mortality among all malignant tumors. ALK-positive non-small cell lung cancer (ALK+ NSCLC) is a relatively rare and dangerous subtype, with patients suffering from a high incidence rate of brain metastases.
Lung cancer is a major type of cancer in the world, with the highest morbidity and mortality among all malignant tumors. ALK-positive non-small cell lung cancer (ALK+ NSCLC) is a relatively rare and dangerous subtype, with patients suffering from a high incidence rate of brain metastases. Statistics show that about 55% of ALK-positive advanced NSCLC patients will develop brain metastases during the treatment process, which is a serious challenge facing oncologists. In recent years, the application of targe…
Protein identification here refers to the accurate screening and identification of proteins using certain biochemical and physical methods. Traditional protein identification methods, including immunoblotting, comigration analysis of known or unknown proteins, and chemical sequencing of endopeptides, are complicated, time-consuming, and less accurate.
Methods in protein identification Protein identification here refers to the accurate screening and identification of proteins using certain biochemical and physical methods. Traditional protein identification methods, including immunoblotting, comigration analysis of known or unknown proteins, and chemical sequencing of endopeptides, are complicated, time-consuming, and less accurate.   Protein identification methods have evolved fro…
16S/18S/ITS amplicon sequencing has now been a well-established method. Due to its low cost, shorter cycle and low quality requirement of the sample, 16S/18S/ITS amplicon sequencing is widely used in the study of microorganisms.
16S/18S/ITS amplicon sequencing has now been a well-established method. Due to its low cost, shorter cycle and low quality requirement of the sample, 16S/18S/ITS amplicon sequencing is widely used in the study of microorganisms. 16S/18S/ITS amplicon sequencing reveals the species of microorganisms in environmental samples and their differences, relative abundance, population structure and evolutionary relationships. It plays an important role in the research of microorganisms and human health, agriculture and animal husbandry, environmental detection and t…
16S/18S/ITS amplification sequencing uses the next/third generation sequencing platform and performs high throughput sequencing of PCR products from specific regions such as 16S rDNA/18S rDNA/ITS/ functional genes. It overcomes the disadvantage of some microorganisms that is difficult or impossible to culture, and obtains the information of microbial community structure, evolutionary relationships and microbial correlation with environment in environmental samples.
16S/18S/ITS amplification sequencing uses the next/third generation sequencing platform and performs high throughput sequencing of PCR products from specific regions such as 16S rDNA/18S rDNA/ITS/ functional genes. It overcomes the disadvantage of some microorganisms that is difficult or impossible to culture, and obtains the inf…
Microbial whole genome sequencing is an important tool for mapping genomes of novel organisms, finishing genomes of known organisms, or comparing genomes across multiple samples. Sequencing the entire microbial genome is important for construction of accurate reference genomes, microbial identification, and other comparative genomic studies.
Microorganisms widely exist in nature and are closely related to human life and production. They are generally divided into fungi, actinomycetes, bacteria, spirulina, rickettsia, chlamydia, mycoplasma and viruses. Microbial whole genome sequencing is an important tool for mapping genomes of novel organisms, finishing genomes of known organisms, or comparing genomes across multiple samples. Sequencing the entire microbial genome is important f…