Articles

As an early-stage life sciences business, securing the right lab space is one of your most important tasks. However, finding a facility that meets all your requirements while remaining affordable can be a significant challenge. Pioneer Group shares a guide to unlocking the perfect lab space.
Here is Pioneer Group's three-step guide for life science start-ups on how to find the right facility while you’re still busy finding your feet. Step 1: Assess Your Lab Space Requirements Equipment and infrastructure: List all the equipment you will need, from essential tools to more specialised pieces of kit. Your lab space needs to provide the equipment and optimal number of workstations you need, with consideration to power sources, ventilation, and utility connections required. Workflow: How many pe…

Generative AI is set transform the healthcare sector in a number of ways, promising to reshape traditional medical practices and improve patient outcomes. However, before the technology’s widespread adoption, it is important to understand all of its potential impacts and how to manage them responsibly.
Generative AI is set transform the healthcare sector in a number of ways, promising to reshape traditional medical practices and improve patient outcomes. However, before the technology’s widespread adoption, it is important to understand all of its potential impacts and how to manage them responsibly. Enhancing emergency care There is no doubt that Gen AI will play a key role in emergency care. Through rapid access and clinical analysis of a patient’s past episodes of care, healthcare profes…

One of those technologies is the Enzyme Structure Characterization Service, which provides an in-depth investigation into the structure of enzymes. This article will elucidate this remarkable service that aids the challenge of interpreting and understanding enzyme structure and function relationships.
Enzymes, nature's impressive catalysts, play indispensable roles in numerous fundamental biological processes. Understanding the intricate design of enzymes down to the atomic level is the key to unraveling the mysteries of life, leading to revolutionary advancements in biotechnology, pharmaceutical, and medical fields. One of those technologies is the Enzyme Structure Characterization Service, which provides an in-depth investigation into the structure of enzymes. This article will elucidate…

Enzymes – the silent soldiers of biological systems. They catalyze a staggering number of biological reactions, quietly carrying out vital functions in our bodies, from digestion to DNA replication. The ability to harness the power of enzymes has had far-reaching implications in the realm of biotechnology and medicine. A service that has taken the spotlight in this context is enzyme screening
Enzymes – the silent soldiers of biological systems. They catalyze a staggering number of biological reactions, quietly carrying out vital functions in our bodies, from digestion to DNA replication. The ability to harness the power of enzymes has had far-reaching implications in the realm of biotechnology and medicine. A service that has taken the spotlight in this context is enzyme screening.   E…

The biotechnological world significantly thrives on groundbreaking developments and the continuous advancement of previously established methods to facilitate and enhance biological processes. One such pivotal development is enzyme synthesis, a service that ingeniously combines chemical synthesis with biotechnological applications. This article aims to provide an insightful overview of enzyme synthesis services, outlining its main features, applications, and advantages.
The biotechnological world significantly thrives on groundbreaking developments and the continuous advancement of previously established methods to facilitate and enhance biological processes. One such pivotal development is enzyme synthesis, a service that ingeniously combines chemical synthesis with biotechnological applic…

Lipids are the basic substances that make up biological membranes. Through lipid-lipid interactions and interactions between lipids and other biomolecules, a complex network of lipid metabolism is formed, which is involved in a large number of life activities.
Lipids are the basic substances that make up biological membranes. Through lipid-lipid interactions and interactions between lipids and other biomolecules, a complex network of lipid metabolism is formed, which is involved in a large number of life activities. By studying lipid extracts, information about the lipidome can be obtained. Lipidomics studies lipids in organisms at a systematic level, revealing their interactions and interactions with other biomolecules.   Many abnormal physiological states are associated wit…

Mass spectrometry is one of the most important techniques for antibody drug analysis. It is divided based on its applications in analyzing primary structures and advanced structures.
Mass spectrometry is one of the most important techniques for antibody drug analysis. It is divided based on its applications in analyzing primary structures and advanced structures.   The significant improvement in the performance of the mass spectrometer is mainly based on the development of two ionization technologies: one is the medium-assisted laser desorption/ionization technology, and the other is the electrospray ionization technology. The emergence of these two ionization technologies enables mass spectrometry, which can only detect small molecules, to detect biological macromolecules. In the past…

ICH Q6B provides a set of internationally recognized principles for the characterization of biotechnology products to support the market application of monoclonal antibodies. Before monoclonal antibody drugs are marketed, they must go through a detailed monoclonal antibody characterization process to ensure quality and safety.
ICH Q6B provides a set of internationally recognized principles for the characterization of biotechnology products to support the market application of monoclonal antibodies. Before monoclonal antibody drugs are marketed, they must go through a detailed monoclonal antibody characterization process to ensure quality and safety.   Determination of amino acid composition and extinction coefficient ICH Q6b recommends the use of a variety of hydrolysis and a…

Depending on the position of the first unsaturated bond, PUFAs can be divided into ω-3, ω-6, ω-7, ω-9 series. ω-3 PUFAs mainly include α-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA), etc.
Polyunsaturated fatty acids (PUFAs) are fatty acids that contain two or more unsaturated double bond structures. Depending on the position of the first unsaturated bond, PUFAs can be divided into ω-3, ω-6, ω-7, ω-9 series. ω-3 PUFAs mainly include α-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA), etc. ω-6 PUFAs mainly include linoleic acid (LA), dihomo-γ-linolenic acid (DHGLA), γ-linolenic acid (GLA) and arachidonic acid (AA), etc. There are also ω-7 series and ω-9 series, su…

Despite Alzheimer’s being discovered over 100 years ago, the complexity of the brain and limitations surrounding research/diagnostic methods have historically acted as barriers for Alzheimer's disease (AD) drug development. As a result, market authorisations for AD have been particularly low, with only four drugs treating the symptoms, rather than the causes, approved between 1996 and 2020.
Despite Alzheimer’s being discovered over 100 years ago, the complexity of the brain and limitations surrounding research/diagnostic methods have historically acted as barriers for Alzheimer's disease (AD) drug development. As a result, market authorisations for AD have been particularly low, with only four drugs treating the symptoms, rather than the causes, approved between 1996 and 2020. Recently, how…

With the continuous innovation in bio-technologies, diagnostic development is expected to accelerate rare disease therapy development worldwide.
Rare diseases are characterized by their low prevalence, affecting a small number of people across the world. These diseases often come with significant challenges, including accurate diagnosis, availability of effective treatments, and limited resources for research and development. However, recent advancements in diagnostics technology hold promise for speeding up the field of rare disease therapies.   Rare disease diagnosis can often be a complex and time-consuming process. Many rare diseases have symptoms that overlap with more common conditions, causing misdiagnosis or delayed diagnosis. Additionally, traditional diagnostics methods may…

Life scientists investigate the structure, function, behaviour, interactions, and evolution of living organisms, from the smallest microorganisms to complex ecosystems. They aim to understand the principles and processes that govern life, including biological systems, organisms’ mechanisms, and the relationship between living organisms and their environment. Life science plays a crucial role in fields such as medicine, biotechnology, agriculture, environmental science, and conservation.
What is Life Science? Life science is a branch of science that focuses on the study of living organisms. It encompasses various disciplines such as genetics, zoology, botany, microbiology, ecology, biochemistry, and physiology. Life scientists investigate the structure, function, behaviour, interactions, and…

The COVID-19 pandemic has killed millions of people. Vaccines certainly are the most outstanding ways to prevent major diseases and death, though they haven't eliminated infections. At present, the most effective vaccine is the mRNA vaccine developed by Pfizer-BioNTech and Moderna. Before that, mRNA technology stopped in the lab phase. How to apply mRNA technology to more complex diseases in the future? The ideal and safe delivery vector may be the answer.
Although lipid nanoparticles (LNPs) are the most advanced mRNA delivery carriers in clinical practice, further optimization is still ongoing. An ideal ionizable cationic lipid needs to meet three characteristics: The ionizable hydrophilic amine head can fully realize mRNA enrichment Hydrophobic hydrocarbon tail can promote self-assem…

Paclitaxel is a natural anticancer drug with the molecular formula C47H51NO14. It has been widely used in the clinical treatment of breast cancer, ovarian cancer, and certain head and neck cancers, as well as lung cancer. Its novel and complex chemical structure, extensive and significant biological activity, unique mechanism of action, and scarce natural resources have gained immense favor among botanists, chemists, pharmacologists, and molecular biologists, making it a prominent anticancer star and research focus in the latter half of the 20th century.
Paclitaxel is a natural anticancer drug with the molecular formula C47H51NO14. It has been widely used in the clinical treatment of breast cancer, ovarian cancer, and certain head and neck cancers, as well as lung cancer. Its novel and comp…

The cosmetics and skincare industry is constantly evolving and a recent trend that has emerged is the use of fermented ingredients in skincare products. Fermentation is a microbial metabolic process that has been used for centuries in food and beverage production, and now it has been extended to the cosmetic industry.
What are Fermented Raw Materials? Fermented raw materials are natural ingredients that have undergone a fermentation process. The substrates of fermentation utilized in cosmetics industry include rice, soybeans, milk, and fruits. The substrates are used by microorganisms like yeast, bacteria, and fungi for metabolism or biosynthesis to create beneficial compounds that served as the fermented raw materials for cosmetic skincare product. Here are a few examples of fermentation-g…

Diabetes is a common clinical disease, and with the improvement of living standards, an increase in the number of obese people, and the intensification of aging populations, the incidence of diabetes is increasing year by year.
Diabetes has various types and requires long-term treatment. Antidiabetic drugs are essential for people with the disease. These drugs can be classified into insulin injections and oral antidiabetic medications. Commonly used oral antidiabetic drugs in clinical practice include biguanides (such as metformin), sulfonylurea insulin secretagogues (e.g., glimepiride, glipizide, gliclazide), non-sulfonylurea insulin secretagogues (e.g., repaglinide, nateglinide), α-glucosidase inhibitors (acarbose, voglibose, miglitol), DPP-4 inhibitors (sitagliptin, etc.), and GLP-1 rec…

Nanobodies are the smallest functional single-domain antibodies known to be able to stably bind to antigens, and have unique structural and functional advantages.
What is a Nanobody? The molecular weight of nanobodies is only 12-15 kDa, which retains the antigen binding ability of traditional antibodies. However, nanobodies have higher solubility and stability, and have unique advantages in biological function and biochemical characteristics. Therefore, nanobodies have shown good control effects in disease diagnosis, cancer and infectious diseases. What are Nanobody-Drug Conjugates (NDCs) The development concept of nanobody-drug conjugates (NDCs) is similar to that of antibody drug conjugates (ADC), that is, the antibody in ADC is replaced by a nanobody with higher affinity. Because nanobod…

For a long time, the research and development of each new drug has faced the challenges of high cost and long cycle. In response to these challenges, major pharmaceutical companies have shifted from targeting common diseases to developing drugs for specific diseases. At the same time, these companies are constantly looking for new technologies for new drug development, such as high-throughput screening technology, DNA encoded chemical library, computer-aided drug discovery, and artificial intelligence.
The use of computer simulation for drug development may reduce costs and increase the efficiency and success rate of the drug development process. Since the 1990s, computer methods such as homology modeling, molecular docking, quantitative structure-activity relationship and molecular dynamic…

Cytokinin is a potent growth hormone and is commonly used in plant tissue culture, induction of cell division and shoot proliferation, plant regeneration, and in vitro production of plant secondary metabolites and bioactive molecules.
Introduction of Cytokinin Cytokinin is an organic compound that belongs to the cytokinin family. It is widely used in plant physiology and agriculture due to its beneficial effects on plant growth and yield. Cytokinin is a potent growth hormone and is commonly used in plant tissue culture, induction of cell division and shoot proliferation, plant regeneration, and in vitro production of plant secondary metabolites and bioactive molecules. Cytokinins are a class of natural plant growth regulators that play a crucial role in the regulation of cell divisio…

Organic Field Effect Transistor (OFET) materials have shown great promise for their use in organic bioelectronic devices. These materials offer several advantages that make them attractive for biomedical applications.
What are the Organic Field Effect Transistors (OFETs)? Organic Field Effect Transistors (OFETs) have gained significant attention in recent years due to their unique properties and potential applications in the field of organic electronics. As the demand for flexible and stretchable electronics continues to grow, the development of OFET materials that can withstand mechanical stress and strain becomes crucial. What are the Advancements in Flexible and Stretchable OFET Materials? 1. Elastomeric Substrates: One of the key requirements for achieving flexibility and stretchability…