Articles

Precision-fermented proteins offer the tantalising prospect of radically uncoupling our nutrition from arable land. However, the journey from laboratory titre to multi-kiloton commodity supply chains has many non-trivial hurdles in between.
Protein fermentation describes the microbial population's controlled breakdown and build-up of nitrogenous compounds under specific redox potential, pH balance and substrate limitation constraints. The process generally begins with the extracellular degradation of high molecular weight proteins. Protein hydrolysis by microbial aspartic proteases (fungi) or metalloproteases (bacteria) yields oligopeptides (2–20 residues) that are taken up into the cell via specific oligopeptide permeases. Intracellular di- and tri-peptidases further hydrolyze peptide…

In chemistry, materials science and many industries, polyethylene glycol (PEG) and ethylene glycol (EG) are two very crucial chemicals. Both are structurally similar but very different in terms of physical characteristics, chemical characteristics and functional fields.
Chemical Structure and Molecular Weight Polyethylene Glycol is the polymer form of EG, with its molecular weight varying depending on the degree of polymerization. The molecular weight of PEG generally ranges from hundreds to tens of thousands, while EG has a molecular weight of only 62. This difference in molecular weight leads to significant differences in their physical properties and applications. The polymer structure of PEG gives it higher viscosity and better biocompatibility, whereas EG's low molecular weight r…

In today’s biotech landscape, quality is essential. Good Manufacturing Practice (GMP) guidelines are the cornerstone of safe, effective, and consistent pharmaceutical production. For therapeutics based on peptides or oligonucleotides (TIDES), many of which treat complex or life-threatening conditions, GMP compliance is a foundational element of regulatory approval and patient trust.
Growing Importance of Peptide & Oligonucleotide Therapeutics Peptides and oligonucleotides are transforming modern medicine. Peptide-based drugs have become the fastest-growing segment of chemically synthesized therapeutics, with over 80 approved worldwide, more than 200 in clinical development, and hundreds in preclinical stages (Rossino et al., 2023). Oligonucleotide-based therapies have also seen signi…

In the third quarter of 2025 Coulter Partners drove global executive search for a wide range of life sciences, health, and technology organizations. We successfully placed executives for independent and VC & PE-backed firms, alongside large-cap and mid-cap public companies, filling critical roles across diverse disciplines worldwide.
In the third quarter of 2025, Coulter Partners drove global executive search for a wide range of life sciences, health, and technology organizations. We successfully placed executives for independent and VC & PE-backed firms, alongside large-cap and mid-cap public companies, filling critical roles across diverse disciplines worldwide.   CEO/ C-suite/ Board CEO, Diagnostic & laboratory services (PE-backed), France CEO, Small-molecule therap…

The evolution of China pharmaceutical distributors reflects the nation’s shift toward high-value, globally compliant healthcare exports. From China Medicine Wholesaler networks to HongKong Drug Wholesale Distributor hubs, these enterprises combine scale, precision, and reliability. As global demand for affordable, high-quality medicine continues to grow, collaboration with a reputable China Drug Import and Export Wholesaler or a licensed HongKong Pharmaceutical distributor like HongKong DengYue Medicine offers the best route to sustainable, long-term success.
Introduction: How China Pharmaceutical Distributors Shape Global Trade In the past decade, China pharmaceutical distributors have moved from low-cost suppliers to strategic global partners in healthcare logistics. They not only manufac…

Learn how to create a successful Clinical Development Plan covering Preclinical Development to regulatory approval, ensuring patient safety.
For a drug to be discovered and supplied in the market, it takes 10 to 15 years and costs over $2.6 billion on average. Out of 10,000 compounds that reach early research, only one secures regulatory approval. The life cycle of a drug from research to launch requires the expertise of hundreds of scientists, clinicians, statisticians, regulatory specialists, and extensive animal studies with human clinical trials. Any one error in the whole process can be expensive and time-consuming. A clinical development plan acts as the plan for the whole process, ensuring the proper workflow of the drug discovery.    Clinical Development Plan: An Over…

Many “hard” regions are operationally complex, not clinically weak. Sponsors that hire local CRA and regulatory consultants gain language and regulatory fluency on the ground, faster submissions, fewer errors, and stronger site relationships—turning delays into predictable startup.
Early in my career, I was helping coordinate a Phase II oncology trial across multiple time zones. One site, located in Eastern Europe, kept falling behind. The issue wasn’t patient recruitment. It was communication. The sponsor was based in California, the CRA was based in London, and the site team didn’t speak much English. Even simple updates took days. We lost time, strained relationships, and nearly missed key milestones. That experience stuck with me. And it taught me a lesson more sponsors are starting to…

As hurricanes become more frequent in the Southeast, seismic activity challenges facilities in the West, and snowstorms weigh heavily on the North, disaster-resilient cold storage has become a cornerstone of business continuity planning.
Disaster-Resistant Cold Storage: The New Standard for Business Continuity Engineering for Continuity in Extreme Weather By: Oscar Infanzon, Design Engineer & Manager, Amerikooler For many businesses, cold storage protection is as critical as power or shelter during a natural disaster. Walk-in coolers and freezers safeguard everything from food and beverages to vaccines and raw materials. A single breakdown can mean thousands of dollars in lost product, extended interruptions to business, and in some cases, a breakdown of supply chains that communities r…

New technologies, changed requirements in production and ever more frequent product changes, but also more strict specifications with regard to occupational and environmental protection are significantly changing many production processes. Three trends in mechanical process engineering show this by way of example.
Process intensification  Forward-looking technologies in process technology rely on process intensification and thus efficient use of the time, energy and raw materials used in a process. When mixing and dispersing with new optimised processes, the differences with regard to required energy, volume-specific capacity or newly created phase boundaries compared to conventional technologies such as agitators, injectors or High Speed Dissolvers are significant.   With t…

Achieve clearer, more radiant skin with REFORM Skincare Anti-Blemish Creme. This hyper pigmentation treatment cream is designed to target dark spots, blemishes, and uneven skin tone, helping you restore your skin’s natural glow. Its gentle yet effective formula works to reduce redness, calm inflammation, and prevent future breakouts, making it ideal for all skin types. As a trusted blemish removal cream and face dark spot remover cream, it gradually fades acne scars, age spots, and discoloration for a smoother, even complexion. Lightweight, fast-absorbing, and dermatologist-approved, this cream is your daily solution for healthy, flawless skin.
Say goodbye to stubborn dark spots and uneven skin tone with REFORM Skincare Anti-Blemish Creme. Specially formulated for all skin types, this hyper…

The global cough assist devices market is projected to expand at a compound annual growth rate (CAGR) of around 7% during the forecast period. Market growth is being driven by the increasing prevalence of respiratory and neuromuscular disorders, ongoing technological advancements, and the rising adoption of home-based respiratory care solutions.
Global Cough Assist Devices Market Overview The global cough assist devices market is projected to expand at a compound annual growth rate (CAGR) of around 7% during the forecast period. Market growth is being driven by the increasing prevalence of respiratory and neuromuscular disorders, ongoing technological advancements, and the rising adoption of home-based respiratory care solutions. Cough assist devices, also referred to as mechanical insuffla…

Bioinformatics Market size is growing with a CAGR of 10.2% during the forecast period (2024-2031), and the market is projected to be valued at USD 32,663.77 Million by 2031 from USD 15,135.48 Million in 2023.
Bioinformatics Market Size: Bioinformatics Market size is growing with a CAGR of 10.2% during the forecast period (2024-2031), and the market is projected to be valued at USD 32,663.77 Million by 2031 from USD 15,135.48 Million in 2023. Bioinformatics Market Overview: The Bioinformatics Market focuses on developing software tools, databases, and algorithms that facilitate the collection and analysis of biological data. It supports various applications such as genomics, proteomics, drug discovery, and personalized medicine. The market is driven by the rapid advancement in next-generatio…

Pharmaceutical and life sciences businesses of all types, including smaller or cost-constrained corporates and those with larger budgets, are increasingly familiar with legal finance. It is an essential tool in high-value patent infringement cases in which plaintiffs whose patents have been infringed protect their rights and seek significant damages against one or more defendants, with funding used to cover legal fees and expenses or to accelerate expected damages attributable to asserted patent
Pharmaceutical and life sciences businesses of all types, including smaller or cost-constrained corporates and those with larger budgets, are increasingly familiar with legal finance. It is an essential tool in high-value patent infringement cases in which plaintiffs whose patents have been infringe…

The world of manufacturing is in a constant state of evolution. Across industries, there's a relentless drive for materials that are not only versatile and high-performing but also cost-effective and sustainable. In this landscape, thermoplastic elastomers (TPEs) and thermoplastic polyurethanes (TPUs) have emerged as frontrunners, particularly in the realm of extrusion. Their unique blend of properties makes them ideal for a wide range of demanding market applications. This in-depth exploration will delve into the world of TPE and TPU extrusion, examining their characteristics, benefits, and the pivotal role they play in shaping the future of manufacturing.
The Rise of TPEs and TPUs: A Paradigm Shift in Material Science For decades, traditional materials like rubber and PVC dominated the la…

Because it directly improves lives, clinical research is referred to as a "human impact" career. Researchers help create new treatments, guarantee patient safety and advance medical knowledge each study advances healthcare providing professionals with the fulfillment of truly improving people's health and well-being.
Introduction: The Power of Purpose When people think about careers in science or healthcare, their minds often jump straight to doctors, nurses or lab technicians but there is a vital, often overlooked profession that serves as the bridge between brilliant scientific discovery and a patient receiving a life saving treatment clinical research this field is fundamentally driven by a single purpose making a tangible, positive change in people lives it is a career for those who cra…

Clinical trials are the cornerstone of medical innovation, playing a vital role in advancing health care and developing new therapies. However, the process of conducting clinical trials is becoming increasingly complex and costly. One major challenge is efficient staffing. Is there a framework that can point to a solution? Here’s what you need to know about the current state of play.
The Clinical Research Workforce Crisis Traditional staffing methods are struggling to keep pace with the growing demand for qualified clinical research professionals. Among patient-facing clinical research professionals (CRPs), turnover can be as high as 61% in places.1 A study from the Association of Clinical Research Professionals (ACRP) found that for experienced clinical research associates (CRAs), turno…

China’s pharmaceutical export sector is experiencing a significant transformation, evolving from a primary supplier of generic drugs and raw materials to a global exporter of high-value, innovative therapies. This strategic shift is driven by massive R&D investments and regulatory harmonization with international standards. Major players like Sinopharm, Shanghai Pharmaceuticals, and Jiangsu Hengrui are crucial for global access to essential medicines and new oncology treatments. Specialized wholesalers, including Hong Kong DengYue Medicine Limited, are also vital, focusing on the trade of rare and specialty drugs. This new focus positions Chinese companies as key partners in both commodity supply and cutting-edge biomedical innovation worldwide, boosting global health security and therapeutic diversity.

Adaptive clinical trials indicate a major shift in the drug development process as they implement pre-specified and data-driven changes in medical or drug interventions during the healing process, without violating scientific integrity. Adaptive trials differ from traditional fixed designs in that changes to a treatment, sample size, dose, treatment arms, or endpoints can modified on the basis of interim analyses, and they are conducted in real time rather than waiting until the study is completed.
Adaptive clinical trials are constructed with the flexibility to amend aspects of the study based on interim data analysis, while maintaining the rigor or validity of the clinical trial. Traditional trials, by contrast, follow a predetermined protocol from start to finish. Adaptive clinical trial…

Dental Services Market size is estimated to reach over USD 793.96 Billion by 2032 from a value of USD 425.80 Billion in 2024 and is projected to grow by USD 452.70 Billion in 2025, growing at a CAGR of 8.1% from 2025 to 2032.
Pharmaceutical Grade Sodium Chloride Market Size: Pharmaceutical Grade Sodium Chloride Market size is estimated to reach over USD 810.4 Million by 2032 from a value of USD 502.38 Million in 2024 and is projected to grow by USD 524.37 Million in 2025, growing at a CAGR of 6.20% from 2025 to 2032. Pharmaceutical Grade Sodium Chloride Market Introduction: Pharmaceutical Grade Sodium Chloride (NaCl), commonly known as high-purity salt, is a highly refined and essential raw material used exclusively in medical and pharmaceutical applications. Unlike industrial or food-grade…

The future of clinical trial management is being reshaped by technology, data intelligence, and patient-centric innovation. From AI-driven analytics and blockchain transparency to virtual trials and wearable integration, modern research is becoming faster, smarter, and more compliant. These innovations enhance data accuracy, streamline workflows, and improve participant engagement. With evolving global regulations and decentralized models, life sciences companies are partnering with a reliable Clinical Trial Management Software Development Company to ensure seamless digital transformation. The convergence of automation, cloud platforms, and predictive insights marks a new era of efficiency and collaboration in clinical research.
Clinical trials form the backbone of modern medicine, bridging…