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In the dynamic realm of pharmaceutical innovation, DNA Encoded Libraries (DELs) have emerged as a transformative force, reshaping the landscape of drug discovery.
With the global DNA encoded library market estimated at USD 840 million in 2023 and a projected compound annual growth rate (CAGR) of 16%, their significance cannot be overstated, DELs, integrating cutting-edge technologies from X-Chem, Haystack Sciences, and ZebiAI, are revolutionizing hit identification and lead optimization. Pioneering companies like Relay Therapeutics exemplify the tangible impact of DELs in targeting proteins linked to conditions such as cystic fibrosis and lung diseases. As Pharma leaders navigate the intricate terrain of DNA sequencing, chemical libraries, and machine learning, this guide illuminates the s…
82% of employers rate employee referrals above all other sources for generating the best ROI, with employers saving an average of 13 days and $1,000+ in recruiting costs when hiring a referral. The benefits of an effective ERP go above and beyond financial and time-saving advantages to include things such as improved retention, engagement, productivity, and commitment from employees, helping your workforce thrive.
As a recruitment professional in the life science industry, employee referral programs (ERPs) are a highly effective way of expanding your talent pool, identifying high-quality candidates, and engaging both active and passive talent. 82% of employers rate employee referrals above all other sources for generating the best ROI, with employers saving an average of 13 days and $1,000+…
Omega-3 fatty acids are crucial in proper body functioning. Its main three forms are docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), and eicosapentaenoic acid (EPA).1 Several studies have proved the positive impact of this nutrient on heart and brain health, yet the latest one takes a new spin on auditory health.
Omega-3 fatty acids are crucial in proper body functioning. Its main three forms are docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), and eicosapentaenoic acid (EPA).1 Several studies have proved the positive impact of this nutrient on heart and brain health, yet the latest one takes a new spin on auditory health. A recent study dove into the potential benefits of one type of omega-3 fatty acid in hearing functions, citing DHA levels are inversely correlated with aud…
The 18th Project Portfolio and Resource Management Excellence Conference, set for February 13-15, 2024 in Northern New Jersey, is a crucial event for industry leaders. The conference focuses on optimizing resource management, aligning project strategies, navigating market pressures, and embracing innovation. With a lineup of industry experts and insightful sessions, attendees can expect to gain actionable strategies and valuable connections.
Northern New Jersey, February 13-15, 2024 In an ever-evolving pharmaceutical and biotechnology landscape, effective portfolio and project management are paramount. The 18th Project Portfolio and Resource Management Excellence Conference, set to take place in Northern New Jersey from February 13th to 15th, 2024, promises to be a crucible of insights and…
There is no doubt that Generative AI will transform IT delivery. Dirk Bode, CEO of fme, recommends optimising core business strategy and identifying where Generative AI could be harnessed to support the strategy.
AI, and specifically Generative AI, is going to transform IT delivery as well as a whole host of other corporate functions. Via secure company-wide intranets that draw on open, cloud-based AI platforms, to intelligent bot-enabled business functions and regulatory processes, ChatGPT and tools like it are going to transform the way entire organisations access, collate and distribute knowledge, and create new assets – as well as what they do with all of it. Very soon (if they aren’t already piloting projects) companies will first scrutinise and clean up, then migrate content to a sec…
In this article, we highlight some of the top associations dedicated to regulatory affairs for you to explore. These associations have a proven track record of providing exceptional opportunities for regulatory affairs professionals, and of working collaboratively with members to advocate for excellence in the field.
As a regulatory affairs professional, you’ll know how challenging it can be to navigate complex regulations and ensure compliance. To excel in this dynamic field and advance your career, you could benefit greatly from joining a reputable professional association dedicated to regulatory affairs, opening you up to endless networking and learning and development opportunities. In this article, we highlight some of the top associations dedicated to regulatory affairs for you to exp…
EU GMP Annex 1 requirements related to the Manufacture of Sterile Medicinal Products have come into force. Anna Cluet of Rephine delves into the challenges faced by certain manufacturers when implementing effective Contamination Control Strategies and practical Quality Risk Management, sharing valuable insights and tips for addressing the issues.
In August, the revised EU GMP Annex 1 requirements related to the Manufacture of Sterile Medicinal Products came into force, with implications for contamination control strategies and, by extension, for plant facilities, equipment, manufacturing processes and Quality systems. The updated requirements are designed to increase confidence in these products. Now that they are live, the expectations of auditors have adapted accordingly which will have a…
As a recruiter or hiring manager in the life science industry, it’s crucial to remain objective and impartial during the hiring process to build a diverse and inclusive workforce that brings together a wide range of perspectives and experiences. Biases in the hiring process, whether conscious or not, all too often lead to talented candidates being overlooked, and missing out on opportunities that should be equal for all.
As a recruiter or hiring manager in the life science industry, it’s crucial to remain objective and impartial during the hiring process to build a diverse and inclusive workforce that brings together a wide range of perspectives and experiences. Biases in the hiring process, whether conscious or not, all too often lead to talented candidates being overlooked, and missing ou…
This comprehensive guide to healthcare covers three main aspects: mental health, physical health, and diseases. Mental health, often unseen, is about our cognitive, behavioral, and emotional wellbeing. It’s crucial at every stage of life and affects how we handle stress, relate to others, and make decisions. Common mental health disorders include depression, anxiety disorders, schizophrenia, eating disorders, and addictive behaviors. Physical health is the more visible aspect of healthcare. It involves maintaining a healthy body through good nutrition, regular exercise, and a healthy lifestyle. Common physical health conditions include heart disease, stroke, cancer, diabetes, and respiratory diseases. Diseases pose significant challenges in healthcare. They can be acute or chronic and can affect both mental and physical health.
Biotechnologists work in a variety of settings, including pharmaceutical companies, research laboratories, agriculture companies, and government agencies. In this article, we dive deeper into the role of a Biotechnologist, focusing on the main benefits of this career path and the essential requirements needed to succeed in the field.
A Biotechnologist is a scientist who uses living cells, organisms, and bioprocesses to create new products and technologies that benefit society. Some of their responsibilities include researching and developing new drugs, creating genetically modified crops, studying the mechanisms and functions of living organisms, and using biotechnology to solve environmental issues. Biotechnologists work in a variety of settings, including pharmaceutical companies, researc…
Buffer solutions play an important role in most biopharmaceutical processes, such as purification, isolation, filtration, protein capturing, chromatographic filtration, crystallization steps, and reactions. Being a vital formulation of drug development, buffers are also used to control pH and maintain the stability of drugs in their final form. Buffer manufacturing requires space, higher titers, resources, and a lean operation system, which adds to the cost of drug development. Conventional buffer manufacturing is tedious and consumes time. To overcome the challenges, pharmaceutical industries are either looking for advanced tech-driven buffer manufacturing or outsourcing buffers from third-party vendors.
Recently, the trend of outsourcing buffer manufacturing system has been adopted by ph…
Cell cytometry is a powerful technology that allows rapid multi-parametric analysis of single cells inside the solution. It utilizes fluorescent light signals that pass through the cell suspension and read through detectors such as photomultiplier tubes and photodiodes. The signals are then converted into electronic signals and transferred on the computer devices to create standard written format data files. This novel technology has enabled scientists to do clinical research more efficiently. Cell cytometry plays a crucial role in determining the immune system response, particularly during cancer immunotherapy and drug development.
In both Allogeneic and Autologous cell therapy products, cell cytometry helps to evaluate key drug parameters that help to understand the effectiveness of the…
Most biological agents enter the body directly without passing through the gastrointestinal tract, so in addition to biological activity, relevant authorities have very strict requirements on impurities in drugs. Among them, the host cells residual DNA has always been the focus of regulatory agencies because of its special potential safety risks.
Most biological agents enter the body directly without passing through the gastrointestinal tract, so in addition to biological activity, relevant authorities have very strict requirements on impurities in drugs. Among them, the host cells residual DNA has always been the focus of regulatory agencies because of its special potential safety risks.   Although recombinant protein drugs, antibody drugs, vaccines and other produ…
Car-t cell therapy involves genetically engineering T cells isolated from patients or allogeneic donors to express chimeric antigen receptors (CAR) that specifically recognize and kill tumor cells.
What is CAR T-cell therapy? Car-t cell therapy involves genetically engineering T cells isolated from patients or allogeneic donors to express chimeric antigen receptors (CAR) that specifically recognize and kill tumor cells.   As a "living" drug, CAR-T therapy is very different from traditional drugs. It is a new type of precision targeted therapy for the treatment of tumors. Compared with traditional chemotherapy and hematopoietic stem cell transplantation, it is more precise in killing tumor cells and significantly reduces toxic side effects while improving efficacy.   Cytokines in C…
Fc fusion protein (Fc-Fusion) has a complex and diverse molecular structure, and may contain glycosylation modification sites at amino acid 297 of its Fc fragment and the Fab region of some molecules. Moreover, its biological ligands are structurally diverse, and their glycosylation modifications may also be complex, usually involving multiple N-glycan and O-glycan sites and a large number of sialic acids.
Fc fusion protein (Fc-Fusion) has a complex and diverse molecular structure, and may contain glycosylation modification sites at amino acid 297 of its Fc fragment and the Fab region of some molecules. Moreover, its biological ligands are structurally diverse, and their glycosylation modifications may also be complex, usually involving multiple N-glycan and O-glycan sites&nb…
Phosphatidylglycerol (PG) is a type of phospholipid, a class of molecules that are crucial components of biological membranes. These membranes are found in cells and organelles, and they serve as barriers that separate the interior of these structures from the external environment.
What is Phosphatidylglycerol? Phosphatidylglycerol (PG) is a type of phospholipid, a class of molecules that are crucial components of biological membranes. These membranes are found in cells and organelles, and they serve as barriers that separate the interior of these structures from the external environment.   What are The Sources of Phosphatidylglycerol? Phosphatidylglycerol (PG) is found in a variety of organisms, and its sources can be categorized based on the different biological systems in which it i…
The antibiotics market, valued at a staggering USD 36 billion in 2023, stands as a critical pillar in global healthcare, combating bacterial infections—one of the leading causes of death worldwide. However, as multi-drug resistant bacteria infections loom larger, the arsenal of antibiotics faces depletion, with shortages in key players like penicillin and amoxicillin intensifying the challenge.
Traditional discovery methods, strained by these shortages and hindered by the rise of antimicrobial resistance, are struggling to keep pace. In this tumultuous landscape, the emergence of Artificial Intelligence (AI) becomes a beacon of hope, offering transformative potential. This article delves into the intricacies of the antibiotics market, exploring challenges posed by multi-drug resistant bacte…
In the intricate landscape of bioprocessing, the precision of buffer manufacturing emerges as a critical factor shaping the success of pharmaceutical and biotechnological endeavors. As we navigate the digital age, the art and science of buffer production have evolved significantly, becoming a fascinating journey marked by innovation and sophistication.
The importance of precise buffer design in bioprocessing cannot be overstated. Buffers, aqueous solutions tasked with controlling pH in drug manufacturing processes, serve as the unsung heroes, ensuring the stability of biologics and small molecules throughout production and in their final forms. This becomes particularly pertinent in an era where the global buffer preparation market is projected to grow at a notable CAGR of around 5.9% until…
The pharmaceutical industry is a huge contributor to climate change - what changes can help it go green at last?
The pharmaceutical industry is currently responsible for over four per cent of global carbon emissions and this figure is on track to grow in the coming years. The UK Government has committed in legislation to reach net-zero carbon emissions by 2050, but achieving this goal could hinge on whether or not the industry finds a way to go green. Here Simon Farnfield, event director at Lab Innovations, discusses the changes that are allowing the pharmaceutical industry to go green at last.  Despite being an emissions-producing juggernaut, the pharmaceutical industry rarely faces the same level of scrutiny as other industries because of its role in providing crucial healthcare solu…
Chromatography, a sophisticated analytical technique, plays a pivotal role in various industries, offering a powerful means of separating and analyzing complex mixtures. Derived from the Greek words "chroma" (color) and "grapho" (to write), chromatography enables the detailed examination of compounds within a sample, allowing for precise identification and quantification. Its significance extends across pharmaceuticals, biotechnology, environmental science, food and beverages, and more.
The roots of chromatography can be traced back to the early 20th century when Mikhail Tswett introduced the concept of liquid-phase chromatography. Over the years, chromatography techniques have evolved significantly, driven by technological advancements and a growing demand for more sophisticated analytical…