Articles
The human genome, the genetic code that makes us uniquely human, has been the subject of scientific study and fascination for decades. The human genome contains approximately 3.055 billion base pairs.
The human genome, the genetic code that makes us uniquely human, has been the subject of scientific study and fascination for decades. The human genome contains approximately 3.055 billion base pairs. These are the molecular building blocks of DNA, consisting of adenine (A) paired with thymine (T) and cytosine (C) paired with guanine (G). This vast number is a testament not only to the complexity of the human race, but also to the intricate interplay of genetic factors that influence our physiology, behavior, and predispositions. Billions of base pairs and complex sequences determine ever…
The human genome, the genetic code that makes us uniquely human, has been the subject of scientific study and fascination for decades. The human genome contains approximately 3.055 billion base pairs. These are the molecular building blocks of DNA, consisting of adenine (A) paired with thymine (T) and cytosine (C) paired with guanine (G). This vast number is a testament not only to the complexity of the human race, but also to the intricate interplay of genetic factors that influence our physiology, behavior, and predispositions. Billions of base pairs and complex sequences determine ever…
08-Apr-2024
The Basic Local Alignment Search Tool (BLAST) a heuristic system, meaning it uses clever shortcuts to speed up the search process. "Local" alignments are performed by BLAST. Functional domains are frequently repeated within the same protein as well as across various proteins from different species, indicating that most proteins are modular in nature.
Introduction to FASTQ Format/Files A FASTQ file is a text file that stores the sequence data from clusters that pass the flow cell's filter. Demultiplexing is the first phase in creating a FASTQ file if specimens were multiplexed. Demultiplexing assigns clusters to a specimen based on the index sequence of each cluster (s). The assembled sequences are published to FASTQ files per specimen after demultiplexing. If specimens were not multiplexed…
Introduction to FASTQ Format/Files A FASTQ file is a text file that stores the sequence data from clusters that pass the flow cell's filter. Demultiplexing is the first phase in creating a FASTQ file if specimens were multiplexed. Demultiplexing assigns clusters to a specimen based on the index sequence of each cluster (s). The assembled sequences are published to FASTQ files per specimen after demultiplexing. If specimens were not multiplexed…
08-Apr-2024
A FASTQ file is a text file that stores the sequence data from clusters that pass the flow cell's filter. Demultiplexing is the first phase in creating a FASTQ file if specimens were multiplexed. Demultiplexing assigns clusters to a specimen based on the index sequence of each cluster (s). The assembled sequences are published to FASTQ files per specimen after demultiplexing. If specimens were not multiplexed, the demultiplexing step is skipped, and all clusters are allocated to a single specimen for each flow cell lane.
Introduction to FASTQ Format/Files A FASTQ file is a text file that stores the sequence data from clusters that pass the flow cell's filter. Demultiplexing is the first phase in creating a FASTQ file if specimens were multiplexed. Demultiplexing assigns clusters to a specim…
Introduction to FASTQ Format/Files A FASTQ file is a text file that stores the sequence data from clusters that pass the flow cell's filter. Demultiplexing is the first phase in creating a FASTQ file if specimens were multiplexed. Demultiplexing assigns clusters to a specim…
It’s no secret that the NHS is more stretched than ever before, dealing with tightening budgets, a shortage of staff, and growing waiting lists, all with the constant pressure to see more patients, faster than ever before. This tension trickles down to every member of NHS staff. In fact, a survey found that just a quarter of the NHS workforce believe there are enough staff to do their jobs properly, and a third feel burnt out.
It’s no secret that the NHS is more stretched than ever before, dealing with tightening budgets, a shortage of staff, and growing waiting lists, all with the constant pressure to see more patients, faster than ever before. This tension trickles down to every member of NHS staff. In fact, a survey found that just a quarter of the NHS workforce believe there are enough…
It’s no secret that the NHS is more stretched than ever before, dealing with tightening budgets, a shortage of staff, and growing waiting lists, all with the constant pressure to see more patients, faster than ever before. This tension trickles down to every member of NHS staff. In fact, a survey found that just a quarter of the NHS workforce believe there are enough…
Injected Veterinary Pain Management Drugs Market Size, Share & Industry Analysis Report By Type(Opioids, α2-Adrenergic Agonists, Local Anesthetics, Nonsteroidal Anti-Inflammatory Drugs (NSIDs), Sedatives), By Application (Veterinary Hospitals, Veterinary Clinics, For Retail) By Region, And Forecasts
The injected veterinary pain management drugs market addresses the growing need for effective pain relief solutions for animals, including companion pets, livestock, and exotic species. Pain management in veterinary medicine is essential for improving animal welfare, enhancing recovery outcomes, and maintaining quality of life. Injected pain management drugs play a crucial role in providing rapid and targeted relief for acute and chronic pain in animals undergoing various medical procedures, sur…
The injected veterinary pain management drugs market addresses the growing need for effective pain relief solutions for animals, including companion pets, livestock, and exotic species. Pain management in veterinary medicine is essential for improving animal welfare, enhancing recovery outcomes, and maintaining quality of life. Injected pain management drugs play a crucial role in providing rapid and targeted relief for acute and chronic pain in animals undergoing various medical procedures, sur…
It’s no secret that the NHS is more stretched than ever before, dealing with tightening budgets, a shortage of staff, and growing waiting lists, all with the constant pressure to see more patients, faster than ever before. This tension trickles down to every member of NHS staff. In fact, a survey found that just a quarter of the NHS workforce believe there are enough staff to do their jobs properly, and a third feel burnt out.
It’s no secret that the NHS is more stretched than ever before, dealing with tightening budgets, a shortage of staff, and growing waiting lists, all with the constant pressure to see more patients, faster than ever before. This tension trickles down to every member of NHS staff. In fact, a survey found that just a quarter of the NHS workforce believe there are enough…
It’s no secret that the NHS is more stretched than ever before, dealing with tightening budgets, a shortage of staff, and growing waiting lists, all with the constant pressure to see more patients, faster than ever before. This tension trickles down to every member of NHS staff. In fact, a survey found that just a quarter of the NHS workforce believe there are enough…
In this era of rapidly expanding biological technology, metagenomic screening for enzymes has emerged as a pivotal approach in many industrial and scientific processes. This process paves the way for the discovery of novel enzymes, serving as a powerful tool in biotechnology. To facilitate a better understanding of this intricate yet mind-boggling domain, we, at Creative Enzymes, are presenting a comprehensive yet easy-to-grasp overview of metagenome screening for enzymes.
In this era of rapidly expanding biological technology, metagenomic screening for enzymes has emerged as a pivotal approach in many industrial and scientific processes. This process paves the way for the discovery of novel enzymes, serving as a powerful tool in biotechnology. To facilitate a better understanding of this i…
In this era of rapidly expanding biological technology, metagenomic screening for enzymes has emerged as a pivotal approach in many industrial and scientific processes. This process paves the way for the discovery of novel enzymes, serving as a powerful tool in biotechnology. To facilitate a better understanding of this i…
Understanding the function and behavior of enzymes in various biological processes is essential to numerous scientific sectors, including pharmaceuticals, food, and chemical industries. As the catalytic machinery responsible for driving chemical reactions, the activity of enzymes plays a vital role in these processes. One crucial procedure that aids in the comprehensive understanding of enzymes is Enzyme Activity Measurement (EAM).
Understanding the function and behavior of enzymes in various biological processes is essential to numerous scientific sectors, including pharmaceuticals, food, and chemical industries. As the catalytic machinery responsible for driving chemical reactions, the activity of enzymes plays a vital role in these processes. One crucial procedure that aids in the compre…
Understanding the function and behavior of enzymes in various biological processes is essential to numerous scientific sectors, including pharmaceuticals, food, and chemical industries. As the catalytic machinery responsible for driving chemical reactions, the activity of enzymes plays a vital role in these processes. One crucial procedure that aids in the compre…
The NHS waiting list isn’t going away anytime soon, but by leveraging innovative solutions, such as digital patient engagement portals, the NHS can help patients wait well and transform waiting from a burden to an opportunity. Mark Gannon, Head of Client Solutions at Netcall, emphasises the importance of proactive reassurance for those currently on the waiting list and calls on NHS trusts to place control back into the patient's hands.
By John Clarke, Head of Client Solutions – Health at Netcall Imagine a patient eagerly awaiting their long-anticipated appointment with a specialist, consumed by anxiety and uncertainty. Time seems to stand still as they wait for weeks, or even months, in anticipation. The enduring struggle of patients waiting for healthcare services is a deeply rooted issue…
By John Clarke, Head of Client Solutions – Health at Netcall Imagine a patient eagerly awaiting their long-anticipated appointment with a specialist, consumed by anxiety and uncertainty. Time seems to stand still as they wait for weeks, or even months, in anticipation. The enduring struggle of patients waiting for healthcare services is a deeply rooted issue…
28-Mar-2024
There are various techniques for the preparation of microspheres, and the selection of an appropriate method depends on the physicochemical properties of the drug. Currently, the most widely used methods include emulsion evaporation, phase separation, spray drying, and hot-melt extrusion, each with corresponding products on the market.
Emulsion Evaporation Method The solvent evaporation method is the most widely applied technique for microsphere preparation. In industrial production, it can be carried out using a reaction vessel or a static mixer, each with its advantages and disadvantages. Preparation Techniques in a Reaction Vessel For lipophilic drugs, the water-in-oil (O/W) emulsion method is employed. This involves dissolving lipophilic raw materials in an organic solvent as the oil ph…
Emulsion Evaporation Method The solvent evaporation method is the most widely applied technique for microsphere preparation. In industrial production, it can be carried out using a reaction vessel or a static mixer, each with its advantages and disadvantages. Preparation Techniques in a Reaction Vessel For lipophilic drugs, the water-in-oil (O/W) emulsion method is employed. This involves dissolving lipophilic raw materials in an organic solvent as the oil ph…
28-Mar-2024
In order to more effectively deliver chemotherapy drugs, Small Molecule Drug Conjugates (SMDC), Antibody Drug Conjugates (ADC), and Degradation Antibody Conjugates (DAC) have been successively explored and developed, enhancing the therapeutic index while providing selective delivery. What are their similarities and differences? What are their respective advantages? What is the current status of research and development? What are the prospects? This article analyzes each aspect.
Definitions SMDC consists of a small molecule drug (usually a highly active chemotherapy drug) and a targeting ligand (usually a small molecule), connected through conjugation technology. This conjugate can selectively deliver the drug to disease-related cells, such as cancer cells, thereby increasing efficacy and re…
Definitions SMDC consists of a small molecule drug (usually a highly active chemotherapy drug) and a targeting ligand (usually a small molecule), connected through conjugation technology. This conjugate can selectively deliver the drug to disease-related cells, such as cancer cells, thereby increasing efficacy and re…
28-Mar-2024
Peptide Nucleic Acid (PNA) is a synthetic polymer similar to DNA or RNA. PNA can be said to have been born in Denmark, where it was originally developed by Peter E. Nielsen (University of Copenhagen), Michael Egholm (University of Copenhagen), Rolf H. Berg (Risø National Laboratory), Technical University of Denmark) and Ole Buchardt (University of Copenhagen) invented it in 1991.
Applications of PNA include altering gene expression, serving as inhibitors and promoters, antigene and antisense therapeutics, anticancer agents, antiviral agents, antibacterial and antiparasitic agents, molecular tools and probes for biosensors, DNA Sequence detection and nanotechnology. Genome editing In October 2022, Neubase shifted the focus of its PNA business to gene editing. Neubase, in partnership with a g…
Applications of PNA include altering gene expression, serving as inhibitors and promoters, antigene and antisense therapeutics, anticancer agents, antiviral agents, antibacterial and antiparasitic agents, molecular tools and probes for biosensors, DNA Sequence detection and nanotechnology. Genome editing In October 2022, Neubase shifted the focus of its PNA business to gene editing. Neubase, in partnership with a g…
28-Mar-2024
In recent years, various nucleic acid-based therapies (NBT) have emerged as effective and specific activators of endogenous gene expression.
Unlike gene therapy approaches supplementing gene expression, RNA-targeted therapy enhances protein production by selectively modulating cellular mechanisms mediated by endogenous RNA, such as transcription, splicing, translation, mRNA stability, and subcellular localization. Currently, the US Food and Drug Administration (FDA) and the European Medicines Agency have approved several therapies targeting splicing mechanisms to regulate mutations in exons. These methods can increase the expression of coding and non-coding genes specifically and controllably, reducing development and manufacturing costs and thus expanding the range of treatable diseases. B…
Unlike gene therapy approaches supplementing gene expression, RNA-targeted therapy enhances protein production by selectively modulating cellular mechanisms mediated by endogenous RNA, such as transcription, splicing, translation, mRNA stability, and subcellular localization. Currently, the US Food and Drug Administration (FDA) and the European Medicines Agency have approved several therapies targeting splicing mechanisms to regulate mutations in exons. These methods can increase the expression of coding and non-coding genes specifically and controllably, reducing development and manufacturing costs and thus expanding the range of treatable diseases. B…
From nurturing a positive work culture to empowering and developing your people for success, Pioneer Group sets out some top tips for building a high-performance team as a life science company.
When it comes to recruitment, the life sciences industry is undoubtedly highly competitive. With demand for skilled professionals often outpacing the supply, attracting (and retaining) qualified candidates with the right expertise can be a significant challenge for many life science companies. From nurturing a positive work culture to empowering and developing your people for success, Pioneer Group sets out some top tips for building a high-performance team as a life science company. Invest in Graduate Programmes Investing in graduate outreach can help to bridge the skills gap in life sciences, and…
When it comes to recruitment, the life sciences industry is undoubtedly highly competitive. With demand for skilled professionals often outpacing the supply, attracting (and retaining) qualified candidates with the right expertise can be a significant challenge for many life science companies. From nurturing a positive work culture to empowering and developing your people for success, Pioneer Group sets out some top tips for building a high-performance team as a life science company. Invest in Graduate Programmes Investing in graduate outreach can help to bridge the skills gap in life sciences, and…
Neuropsychiatric Disorders And Treatment Market is projected to reach USD 1,62,214 Million by 2030 at 11.5% CAGR during the forecast period 2022-2030.
Neuropsychiatric Disorders And Treatment Market is projected to reach USD 1,62,214 Million by 2030 at 11.5% CAGR during the forecast period 2022-2030. The Neuropsychiatric Disorders and Treatment Market refers to the segment of the pharmaceutical and healthcare industry that focuses on the diagnosis, management, and treatment of neuropsychiatric disorders, which encompass a broad range of conditions affecting the brain and nervous system, including psychiatric illnesses and neurological disorders. These disorders often involve complex interactions between genetic, environmental, and neurobiological factors, leading to disturbances in mood, co…
Neuropsychiatric Disorders And Treatment Market is projected to reach USD 1,62,214 Million by 2030 at 11.5% CAGR during the forecast period 2022-2030. The Neuropsychiatric Disorders and Treatment Market refers to the segment of the pharmaceutical and healthcare industry that focuses on the diagnosis, management, and treatment of neuropsychiatric disorders, which encompass a broad range of conditions affecting the brain and nervous system, including psychiatric illnesses and neurological disorders. These disorders often involve complex interactions between genetic, environmental, and neurobiological factors, leading to disturbances in mood, co…
One of the most promising technologies that has emerged in recent years is nanoparticle development for drug delivery systems. Nanoparticles are tiny particles with dimensions in the nanometer range, making them ideal for targeting specific tissues or cells in the body.
The field of medicine is constantly evolving, with researchers and scientists striving to find innovative ways to deliver drugs effectively and efficiently. One of the most promising technologies that has emerged in recent years is nanoparticle development for drug delivery systems. Nanoparticles are tiny particles with dimensions in the nanometer range, making them ideal for targeting specific tissues or cells in the body. In this article, we will explore different types of nanoparticle development that are revolutionizing…
The field of medicine is constantly evolving, with researchers and scientists striving to find innovative ways to deliver drugs effectively and efficiently. One of the most promising technologies that has emerged in recent years is nanoparticle development for drug delivery systems. Nanoparticles are tiny particles with dimensions in the nanometer range, making them ideal for targeting specific tissues or cells in the body. In this article, we will explore different types of nanoparticle development that are revolutionizing…
Oxide nanoparticles have found applications in the field of medicine and healthcare. Metal oxide nanoparticles, such as iron oxide nanoparticles, are widely used as contrast agents in magnetic resonance imaging (MRI) due to their paramagnetic properties.
Oxides nanoparticles have gained significant attention in various fields due to their unique properties and potential applications. Synthesis Methods of Oxides Nanoparticles The synthesis of these nanoparticles requires careful consideration of the method employed, as it can greatly influence their physical and chemical characteristics. Chemical Precipitation Method The chemical precipitation method is one of the most widely used techniques for the synthesis of oxides nanoparticles. In this method, a precursor solution containing metal…
Oxides nanoparticles have gained significant attention in various fields due to their unique properties and potential applications. Synthesis Methods of Oxides Nanoparticles The synthesis of these nanoparticles requires careful consideration of the method employed, as it can greatly influence their physical and chemical characteristics. Chemical Precipitation Method The chemical precipitation method is one of the most widely used techniques for the synthesis of oxides nanoparticles. In this method, a precursor solution containing metal…
In recent years, some studies have been conducted on the delivery of anticancer drugs, genes and peptides through garphene derivatives.
The Importance of Drug and Gene Delivery Due to its poor water solubility, non-specific delivery and severe side effects, chemotherapy drugs have many limitations in fighting cancer clinically. On the other hand, gene therapy has also been widely explored as another option for cancer treatment, but the lack of safe, selective and effective gene delivery vectors hinders the further clinical application of gene therapy. Recently, various nanomaterial-based drug and gene delivery systems have been intensively studied and proved to be promising in cancer treatment. Accelerate Research and Practice of Graphene in Drug and Gene Delivery Graphene is cons…
The Importance of Drug and Gene Delivery Due to its poor water solubility, non-specific delivery and severe side effects, chemotherapy drugs have many limitations in fighting cancer clinically. On the other hand, gene therapy has also been widely explored as another option for cancer treatment, but the lack of safe, selective and effective gene delivery vectors hinders the further clinical application of gene therapy. Recently, various nanomaterial-based drug and gene delivery systems have been intensively studied and proved to be promising in cancer treatment. Accelerate Research and Practice of Graphene in Drug and Gene Delivery Graphene is cons…
18-Mar-2024
Learn Clinical Research, Clinical Data Management Training in Bangalore. (CDM)Clinical Data Management Online Classes 2024 for Life Science graduates Industry Expert.
Career in Clinical Data Management In the rapidly evolving landscape of healthcare, the role of Clinical Data Management (CDM) is gaining prominence as a crucial driver of innovation and progress. This blog explores the future of healthcare through the lens of professionals in Clinical Data Management, offering valuable career perspectives and insights into the transformative impact of data in the industry. Opportunities: Career opportunities in Clinical Data Management are diverse and rewarding, career offering as Clinical Data Coordinator which is an Entry-level role, responsible for data entry, verification, an…
Career in Clinical Data Management In the rapidly evolving landscape of healthcare, the role of Clinical Data Management (CDM) is gaining prominence as a crucial driver of innovation and progress. This blog explores the future of healthcare through the lens of professionals in Clinical Data Management, offering valuable career perspectives and insights into the transformative impact of data in the industry. Opportunities: Career opportunities in Clinical Data Management are diverse and rewarding, career offering as Clinical Data Coordinator which is an Entry-level role, responsible for data entry, verification, an…
19-Apr-2024
Clinical Research Organisations (CROs) play a crucial role in advancing medical knowledge and therapeutic innovations. As vital intermediaries between pharmaceutical and biotechnology companies, healthcare professionals, and regulatory bodies, CROs help facilitate the clinical development of new drugs, devices, and treatments.
Clinical Research Organisations (CROs) play a crucial role in advancing medical knowledge and therapeutic innovations. As vital intermediaries between pharmaceutical and biotechnology companies, healthcare professionals, and regulatory bodies, CROs help facilitate the clinical development of new drugs, devices, and treatments. In this article, we explore the multifaceted functions of modern CROs, highlighting the significant impact they have on shaping the future of h…
Clinical Research Organisations (CROs) play a crucial role in advancing medical knowledge and therapeutic innovations. As vital intermediaries between pharmaceutical and biotechnology companies, healthcare professionals, and regulatory bodies, CROs help facilitate the clinical development of new drugs, devices, and treatments. In this article, we explore the multifaceted functions of modern CROs, highlighting the significant impact they have on shaping the future of h…
