Articles

At present, the application of AI technology in the field of biomedicine mainly covers four sub-fields: drug research and development, medical imaging, auxiliary diagnosis and treatment, and genetic analysis.
Thanks to the technological revolution of computer information technology and thanks to the accumulation of a large amount of data, artificial intelligence (AI) technology has achieved rapid development in the past decades. At present, the application of AI technology in the field of biomedicine mainly covers four sub-fields: drug research and development, medical imaging, auxiliary diagnosis and treatment, and genetic analysis. According to a data report from Global Market Insight, drug development is the largest market segment of the global artificial intelligence medical market, wit…

During the Covid pandemic, digital has transformed everything from patient engagement and recruitment to continuous health monitoring and remote treatment. Kathleen O’Brien of Amplexor Life Sciences reflects on the challenges and considerations.
Process digitalisation is one positive development that has emerged from the Covid pandemic. Reliance on digital channels for conducting consultations, managing treatments and measuring outcomes has allowed many services to continue almost unhindered and the way has been paved for a more digital future. Life sciences companies must now lean into the trend and make the most of the bigger part that remote care and monitoring will play in ongoing treatment models. The FDA’s Digital Health Center of Excellence in the US sets out many of the opportunitie…

With the increasing supply of good quality fresh and cryo-preserved human hepatocytes (such as ABC-TC3646, AcceGen advanced technology), researchers can further apply this in vitro model to advance our knowledge of liver functions, the mechanisms underlying the regulation and drug-induced changes of metabolic enzyme expression and hepatocellular integrity.
Hepatocytes are parenchymal cells that constitute as much as 80% of the total liver volume and mediate a number of vital liver functions, such as the control of lipid and carbohydrate homeostasis, the synthesis of various proteins, the storage of vitamins, the processing of bile, immunological defense, and the biotransformation of endogenous molecules and xenobiotics [1]. Human hepatocytes directly reflect the specific metabolism and func…

A brief introduction to human tumor cell lines. History, benefits and applications of human cancer cell lines.
Tumor cell lines (or cancer cell lines) are derived from the cancerous growths on an organ in a human or animal subject. These cell lines have undergone laboratory modifications that render them immortalized—they are capable of proliferating indefinitely in an in vitro environment. For that reason, tumor cell lines have become invaluable tools in the field of cancer research.   History of Human Cancer Cell Lines In the first half of the 20th century, various experiments demonstrated that animal cell lines could be maintained in an in vitro environment. The first human cell line was established in 1951, from cervical carcinoma cells taken from 30-year-old H…

BV-2 shares properties with body macrophages with respect to the antigen profile, their phagocytic capacity and antimicrobial activity. BV-2 is widely used as an alternative model system for primary microglia and neurodegenerative disease model in vitro. The model is usually induced by Lipopolysaccharide (LPS) treatment.
BV-2 Cells Derivation and biomarker BV-2 is a type of microglial cell derived from C57/BL6 murine. The BV2 cells are immortalized by v-raf /v-myc carrying J2 retrovirus. BV2 express nuclear v-myc and the cytoplasmic v-raf oncogene products as well as the env gp70 antigen at the surface level. BV2 microglia cell line retains microglia morphological and functional characteristics. In accordance with v-raf/v-myc expressed characters, the metabolic and proliferation rate of in…

A white paper shedding new light on the accelerated shift to digital engagement in Medical Affairs.
COVID-19 has had devastating effects on individuals, economies, and health systems around the world. If there is a pandemic silver lining, part of it may be that the disruption has created an opportunity for biopharmaceutical companies of all sizes to revisit how they engage with customers, including the chance to take a fresh look at how their Medical Affairs teams communicate with increasingly important stakeholders. While communication prefer- ences had already been shifting toward more digital platforms over the last several years, COVID amplified the dynamic, creating an urgency for biopharma manufacturers to quicken the pace of change.This paper sheds new light on several aspects of…

ASAP Innovations diversifies its pipeline of niche PPE products for workers and advises on the importance of implementing a stricter selection process.
Organisations must stop applying a one-size-fits-all approach to PPE and ensure workers are provided with protection specially designed for an intended use. This is according to leading glove and face mask manufacturer, ASAP Innovations which says that it is imperative that distributors and purchasers understand the importance of tailoring PPE for specific industry needs. Providing suitable PPE has been at the epicentre of multiple news stories, with The Royal College of Nursing calling for an update on guidelines for suitable protective equipment. However, whilst PPE plays a major role in the healthcare industry, it is a…

Pharmacovigilance workloads are soaring during the pandemic but regulators still require reports to be filed within 24 hours. With notifications of adverse effects coming in via a whole host of sources and in multiple languages, the mounting workload creates risks for pharma companies. Kathleen O’Brien of Amplexor Life Sciences outlines an action plan to bring worldwide AE reporting under control.
During the pandemic, pharmacovigilance (PV) workloads have soared. Patients already taking drugs long-term also tend to be at higher risk for Covid, so some risk factors have multiplied and clinicians have had to be extra vigilant about drug interactions. At the same time, the market has been flooded with new or updated products as regulators and pharma companies have rushed to develop medicines t…

The COVID pandemic has been the catalyst to change the way the pharmaceutical industry (Pharma) engages with HCPs. Partnering with large and small pharma alike, this whitepaper explores Amplity's flexible model tailored to each customer’s needs leveraging the benefits of remote and in-person promotion, optimizing the promotional mix across personal and non-personal channels, and ultimately providing relevant, timely, and credible information to HCPs.
COVID-19 has had a profound impact on the commercialization of pharmaceuticals in the United States. Health Care Provider (HCP) information-seeking needs and preferences have changed dramatically in response to the outbreak, as have the options for pharmaceutical manufacturers to meet these new needs and preferences. Indeed, in a curious twist…

In this article, we outline ten of the top pharmaceutical companies in the world, including Roche, Johnson and Johnson and Pfizer.
In this article, we outline ten of the top pharmaceutical companies in the world… Roche Founded in Switzerland in 1896, Roche has been a pioneer in healthcare for almost 125 years. The company discovers innovative pharmaceuticals and diagnostics to help millions of patients globally, and is the global leader in cancer treatments; with medicines treating breast, skin, colon, lung, and numerous other cancers. Roche also offers a diverse portfolio of biopharmaceuticals, with 17 currently on the market. The company has over 90,000 employees working across more than 100 countries, and group sales at the end of 2020 reached over $63 billion, with Roche’s pharmaceutica…

Updated insights on the U.S. infusion pump market have been released, addressing brand-level metrics including average selling prices (ASPs), revenue by brand, market share by revenue, market share by unit, and total units sold. Based on the data, revenue and units sold have continued to decline as COVID-19 hit.
Infusion pumps are used for patients who require an infusion of fluids as part of their therapy. These fluids contain medication for disease management, pain control, provision of nutrients, faster recovery, hydration, and blood replenishment. Within this analysis, five market segments were analyzed in detail: Electronic ambulatory pumps PCA pumps Syringe pumps Large volume pumps Others iData’s recently completed MedSKU analysis includes an overview of the companies, products, and…

Online interviewing platforms are becoming more important in 2021 than ever before, and pharma companies including Novo Nordisk, Novartis and Takeda are already making the most of them. In this article, we outline 17 online interviewing platforms for both on-demand applicant screening and live interviewing for you to consider, drawing on the unique features each has to offer.
Online interviewing platforms are becoming more important in 2021 than ever before, and pharma companies including Novo Nordisk, Novartis and Takeda are already making the most of them. In this article, we outline 17 online interviewing platforms for both on-demand applicant screening and live interviewing for you to consider, drawing on the unique features each has to offer… Retorio Retorio is an AI video interviewing…

Penn State academics are using SR-Tek transparent pressure vessels to determine optimum production conditions for biopharmaceuticals in a bid to increase yields and prevent contamination events.
Biopharmaceuticals, or biologically produced medications, are rapidly being used to treat a host of chronic and genetic conditions. Expected to be worth $535 billion by 2027, the biopharmaceutical market is currently undergoing significant growth. However, production issues are hampering the industry’s ability to meet demand. Now a research team from Pennsylvania State University is looking to tackle one of the major bottlenecks in biopharmaceutical production – purification and filtration. Led by Dr Andrew Zydney, 14 graduate students from the university are investigating system effects, including…

Australia is home to a multi-billion-dollar pharmaceutical market that has been growing continuously over the past decade especially. Here are ten of the top pharmaceutical companies in the country as of 2021.
Australia is home to a multi-billion-dollar pharmaceutical market that has been growing continuously over the past decade especially. Here are ten of the top pharmaceutical companies in the country as of 2021… Pfizer Pfizer has manufacturing sites in Sydney, Melbourne, Perth and Adelaide, and its products are used in hospitals and pharmacies across the country. Pfizer Australia offers a portfolio containing some of the world’s best-known prescription medicines, vaccines, and OTC products. Roche Roche is dedicated to improving the health and wellbeing of people in Australia and has had…

All drugs have side effects and can be poisonous if used in in too large doses. Pharmacovigilance is a set of legally required activities performed by the pharmaceutical companies to ensure their drug has an acceptable benefit-risk profile. The adverse drug reactions can lead to hospitalization and even to death in worst cases. We list here how drugs could be made safer and how the number of deaths and hospitalization caused by drugs could be reduced. There are other ways to do it, and the actions presented here might not be the best ways in all countries, but we have explained our choices and we would be happy to hear alternative opinions from other people, authorities, and companies.
What is pharmacovigilance? The goal of pharmacovigilance is to make drugs safer by monitoring the benefit…

With its unique manufacturing technology, 3D printing allows us to produce unprecedented types of items.
With its unique manufacturing technology, 3D printing allows us to produce unprecedented types of items. However, the real advantage of 3D printing technology lies in its printing materials. Only by developing more new materials can the application fields of 3D printing technology be expanded. At present, 3D printing materials mainly include engineering plastics, photosensitive resins, rubber materials, metal materials, and ceramic materials. In addition, food materials such as colored plaster materials, artificial bone meal, cellular biological materials, and sugar can also be used in the field of 3D printing. What kind of polymer materials can be used in 3D Printing? Engineering plasti…