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Following a series of disruptions to worldwide supply chains, regulators across the globe have initiated fresh guidelines for manufacturers in the Life Sciences sector and those responsible for marketing authorisations. The aim is to safeguard uninterrupted global availability of crucial medication supplies. Juan Torrijos Lopez, GMP consultant at Rephine, discusses the regulatory requirements set by the FDA and EMA regarding the maintenance of robust supply chains.
Following a series of disruptions to worldwide supply chains, regulators across the globe have initiated fresh guidelines for manufacturers in the Life Sciences sector and those responsible for marketing authorisations. The aim is to safeguard uninterrupted global availability of crucial medication supplies. Juan Torrijos Lopez,…
The Signal Heads Market is witnessing substantial growth, driven by increasing urbanization, expanding road networks, and the need for advanced traffic management solutions.
Introduction In today's fast-paced world, traffic management is of paramount importance, ensuring safety and smooth flow of vehicles on our roads. A crucial component of this system is the signal head, those familiar red, yellow, and green lights we encounter daily at intersections. Signal heads play a pivotal role in controlling traffic, and understanding the Signal Heads Market is essential for both industry players and stakeholders. In this article, we delve into the key takeaways from a recent market research report on the Signal Heads Market, including market size, segmentation, top players, and the competitive lan…
This market research report dives deep into the Smartphone LiDAR Market, exploring its size, segmentation, competitive landscape, market developments, and top players. Let's delve into the key takeaways from this comprehensive study.
In the ever-evolving landscape of technology, the Smartphone LiDAR market has emerged as a significant player, reshaping the way we interact with our handheld devices. This market research report dives deep into the Smartphone LiDAR Market, exploring its size, segmentation, competitive landscape, market developments, and top players. Let's delve into the key takeaways from this comprehensive study. Smartphone LiDAR Market Size: The Smartphone LiDAR market has witnessed impressive growth in recent years. According to our research, the market size is projected to…
multiplex assays market is valued at an estimated USD 3.5 billion in 2022 and is projected to reach USD 5.3 billion by 2027, at a CAGR of 8.8%
Introduction In recent years, the healthcare and biotechnology industries have witnessed a paradigm shift with the introduction of cutting-edge technologies. One such breakthrough is the Multiplex Assays Market, which has revolutionized the way researchers conduct various diagnostic and research applications. This article aims to provide an in-depth overview of the Multiplex Assays Market, exploring its significance, applications, advantages, and potential for the future. "Multiplex Assays Market by Product & Service (Consumables, Instruments, Software & Services), Type (Nucleic Acid, Protein), Technology (Flow Cytometry, Luminescence), Appli…
B-lymphocyte antigen CD20 (called CD20) is known as an activated-glycosylated phosphoprotein which is expressed on the surface of all B-cells. CD20 is involved in the regulation of trans-membrane Ca2+ conductance and also play critical roles in cell‐cycle progression during human B cell proliferation and activation.
Structure of CD20 The CD20 protein presents a unique arrangement, featuring four membrane-spanning domains. Notably, both the amino and carboxy termini of the protein are positioned within the cytoplasm. An intriguing aspect of this structure is the existence of a short extracellular segment comprising approximately 43 residues, found between the third and fourth transmembrane regions[1]. This distinctive configuration, deeply embedded in the cell membrane, serves to prevent t…
Retaining remote life science talent requires special attention to keeping these employees engaged, motivated and productive, whilst also ensuring they feel connected to the company culture. In this article, we explore 10 strategies for retaining remote life science talent, helping your workforce to thrive regardless of where they work.
As the life science industry continues to adapt to the changing work landscape, remote working has become a prevalent practice. While remote work offers flexibility and convenience for employees, it can pose unique challenges for recruiters and hiring managers in the industry. Retaining remote life science talent requires special attention to keeping these employees engaged, motivated and productive, whilst also ensuring they feel connected to the company cu…
Interleukin-1 family is a family of cytokine proteins, which includes IL-1α, IL-1β, IL-18 and a series of related molecules. Members of the IL-1 family play an important role in immune regulation and inflammatory responses. By binding to specific receptors, they trigger intracellular signaling, triggering inflammation, activation of immune cells, and modulation of biological effects
IL-1α and IL-1β: Key Players in Inflammation and Disease Pathogenesis IL-1α and IL-1β represent the prototypical and crucial members of the IL-1 family, which are synthesized by various cells, including monocytes, macrophages, dendritic cells, and others. These interleukins assume a significant regulatory function in the inflammatory response, stimulating immune cells to generate additional inflammatory mediat…
Programmed death protein 1 (PD1) is a common immunosuppressive member on the surface of T cells and plays an imperative part in downregulating the immune system and advancing self-tolerance. Its ligand programmed cell death ligand 1 (PDL1) is overexpressed on the surface of malignant tumor cells, where it binds to PD1, inhibits the proliferation of PD1-positive cells, and participates in the immune evasion of tumors leading to treatment failure. The PD1/PDL1-based pathway is of great value in immunotherapy of cancer and has become an important immune checkpoint in recent years.
The Structure and Function of PD-1 PD-1 is a type I membrane protein composed of 288 amino acids. As a member of the CD28/CTLA-4 family of T cell regulators, PD-1 plays a crucial role in modulating T cell responses…
If you’re a medical doctor seeking new career paths beyond clinical practice, the pharmaceutical and life science sector offers a wide range of opportunities that can capitalise on your unique skill set. Here, we explore 10 potential career paths for you to consider, allowing you to continue making a valuable impact on patients’ lives whilst diversifying your professional experiences.
If you’re a medical doctor seeking new career paths beyond clinical practice, the pharmaceutical and life science sector offers a wide range of opportunities that can capitalise on your unique skill set. Here, we explore 10 potential career paths for you to consider, allowing you to continue making a valuable impact on patients’ lives whilst diversifying your professional experiences. Read the full article on…
DEGs, or Differentially Expressed Genes, are genes whose expression levels show significant differences between two or more conditions or experimental groups. In genetics and genomics research, gene expression refers to the process by which information encoded in a gene's DNA sequence is converted into functional proteins or RNA molecules.
What Are DEGs in Genetics? DEGs, or Differentially Expressed Genes, are genes whose expression levels show significant differences between two or more conditions or experimental groups. In genetics and genomics research, gene expression refers to the process by which information encoded in a gene's DNA sequence is converted into functional proteins or RNA molecules.   When studying gene expression, researchers often compare gene expression profiles b…
Single-cell RNA sequencing enables improved disease understanding through cell subtyping, which can aid in identifying and prioritizing novel drug targets. By profiling gene expression patterns at the single-cell level, researchers can identify dysregulated cell populations or specific cell types associated with diseases. This information helps in selecting relevant targets for further investigation.
What Are the Advantages of Single-Cell RNA Sequencing? One of the significant advantages of scRNA-seq in drug discovery is its impact on target identification. By allowing researchers to dissect complex tissues and diseases at the cellular level, scRNA-seq enables the identification of distinct cell subtypes and their gene expression profiles. This information can lead to a better und…
Diverse microbial communities play a vital role in the different biochemical processes and energy production and occupy a particular niche in the environment. Mapping the microbiome aids in understanding key events and interactions in a specific ecosystem. Metagenomics and other omics technology help in profiling and recognizing the function of microbiomes.
The term microbiome comes from the Greek word micro which means small and bios meaning life. It is defined as "a characteristic microbial community occupying a reasonable well-defined habitat which has distinct physiochemical properties". Many researchers in the past defined microbiome based on different contexts such as ecological and genetic aspects. However, scientists noted some gaps in these proposed definitions, and in a recently p…
Microorganisms, specifically bacteria, have been classified into several groups depending on different characteristics such as physical appearance, culture properties, energy and nutrient requirement, biosynthetic capacity, optimal growth temperature, oxygen requirement, among others. One of the classifications used to separate bacteria is oxygen requirement, which divides the lot into two main groups namely the aerobes or the bacterial species that generally require oxygen for growth, and the anaerobes or the bacteria that do not need oxygen for growth.
Microorganisms, specifically bacteria, have been classified into several groups depending on different characteristics such as physical appearance, culture properties, energy and nutrient requirement, biosynthetic capacity, optimal growth t…
Due to their rarity, rare diseases often face challenges in research funding, clinical trials, and access to specialized healthcare services.
What is a rare disease? A rare disease, also known as an orphan disease, is a medical condition that affects a small number of people. In most countries, a disease is considered rare when it affects fewer than 1 in 2,000 individuals. However, this definition may vary from country to country.   Rare diseases can be genetic, meaning they are caused by an alteration or mutation in a person's genes, or they can be acquired later in life due to infections, environmental factors, or other causes. These conditions are often chronic, progressive, and potentially life-threatening. They can have a wide range of symptoms and affect various organs and system…
Thermo Fisher Scientific (US) and Tecan Group (Switzerland) are Leading Players in the Lab Automation Market
Introduction In the fast-paced world of scientific research and discovery, time and precision are of the essence. Laboratories across the globe are constantly seeking ways to optimize their workflows, reduce manual errors, and enhance overall efficiency. This quest for progress has led to the rapid growth of the Lab Automation Market, offering innovative solutions that redefine the way science is conducted. From pharmaceuticals to biotechnology, from academics to industrial applications, Lab Automation has become an indispensable tool, empowering researchers and scientists alike. The global lab automation market is projected to reach USD 7.1 billion by 2028 from USD 5.1 billion in 20…
There are only a few months left before the final November 27th, 2023 deadline for DSCSA regulations take effect, yet many manufacturers have yet to reach compliance. Christoph Krahenbuhl, Senior Director at Excellis Health Solutions and former AstraZeneca serialisation lead, shares insight into the current challenges; and how to overcome them in time.
The forthcoming Drug Supply Chain Security Act (DSCSA) final milestone will affect every pharmaceutical manufacturer operating in the US market. This critical legislation requires pharma companies to serialise their products with a unique identifier on each item of medication to make every product fully traceable. Some basic US requirements are similar to what manufacturers have had to put in place for other markets – such as each pack requir…
In this article Paul Vanden Branden, Director at SciMed, an exhibitor at Lab Innovations 2023 and member of the show’s advisory board, discusses ways that laboratories can update experimental methods and solvent selection to be more sustainable without harming results.
Research labs are complicated environments and it is not always clear what can be done to improve sustainability. To date, most of the discussion around sustainability has focussed on the energy efficiency of instruments and equipment, such as fume hoods and cryogenic freezers. While this is important, it means that things like chemical and solvent selection are overlooked. Here Paul Vanden Branden, Director at SciMed, an exhibitor at Lab Innovations 2023 and member of the show’s advisory board, discusses ways that laboratori…
Enzymes, nature's molecular architects, have been at the heart of industrial processes for decades. Today, the dynamic field of Enzyme Engineering and Modification is driving these biocatalysts towards unprecedented capabilities, triggering a wave of transformative applications across diverse sectors.
Enzymes, nature's molecular architects, have been at the heart of industrial processes for decades. Today, the dynamic field of Enzyme Engineering and Modification is driving these biocatalysts towards unprecedented capabilities, triggering a wave of transformative applications across diverse sectors.   Decoding Enzyme Engineering Enzyme Engineering stands as a cornerstone of modern biotechnology, involving the strategic redesign of enzymes to amplify their inherent functionalities or int…