Articles

RNA synthesis is a fundamental technique in molecular biology that allows researchers to design and create specific RNA molecules tailored to their experimental needs.
These custom RNA molecules play crucial roles in a wide range of applications, including gene expression studies, functional genomics, and RNA interference experiments. The process of custom RNA synthesis involves the production of RNA molecules with precise sequences and modifications, enabling researchers to investigate various biological processes with high specificity and efficiency.   In RNA synthesis, there are two main methods commonly used: chemical synthesis and enzymatic synthesis. Custom chemical synthesis involves the step-by-step assembly of RNA molecules using nucleotide building blocks and chemic…

PG is commonly used as an excipient in a variety of drugs and is also approved for use in food and cosmetics.
About Propylene Glycol Propylene glycol (PG) is a clear, odorless, and viscous liquid that is miscible with water and many organic solvents. It is a small molecule that is structurally different and unrelated to PEG, despite a similar name. PG is commonly used as an excipient in a variety of drugs and is also approved for use in food and cosmetics. In addition, it has a wide range of other practical applications, such as antifreeze agent, cutting fluid, and as an additive to latex paints and coatings to increase freeze-thaw capabilities. Propylene Glycol as An Excipient Excipients are essential supports for active ingredients in drugs, vaccines and other products, contributing…

In an ever-evolving field like medical writing, versatility is not just a skill – it’s a necessity. As the demands of the healthcare sector grow increasingly complex, you should be looking for new ways to diversify your portfolio and effectively demonstrate your range of skills and depth of knowledge.
In an ever-evolving field like medical writing, versatility is not just a skill – it’s a necessity. As the demands of the healthcare sector grow increasingly complex, you should be looking for new ways to diversify your portfolio and effectively demonstrate your range of skills and depth of knowledge. A well-crafted, diverse portfolio will showcase your competence across various sub-disciplines, demonstrating your versatility and positioning you for success in the competitive 2024 job market. …

Mtech Access are now part of Petauri. This marks a significant and exciting milestone in our journey, and aligns with our commitment to partnering with industry to bring life-enhancing technologies to market, providing more patient choice and meeting the needs of the healthcare environment.
What this means for our clients: Enhanced services: This strategic move will allow us to offer greater breadth and depth of technical and consulting experience, as well as market coverage for our clients. Continuity and stability: The quality of work and client service that you have come to expect, along with your current projects and relationships, will remain unchanged. Innovative solutions: Leveraging the strengths of the Petauri group, we will build on our commitment to growth and inn…

Personalised benefits packages are tailored to meet the individual preferences and needs of each employee, replacing standard benefits packages that are offered to all employees. According to a 2022 survey, 50% of workers would be prepared to accept a pay reduction in exchange for more tailored benefits, and 74% said they would work harder for an employer that provided benefits that support individual needs.
Personalised benefits packages are tailored to meet the individual preferences and needs of each employee, replacing standard benefits packages that are offered to all employees. According to a 2022 survey, 50% of workers would be prepared to accept a pay reduction in exchange for more tailored benefits, and 74% said they would work harder for an employer that provided benefits that sup…

The growing number of investments in T-cell transfer looks promising for market growth. Several new clinical trial initiations for T-cell therapies have risen exponentially over the years. The lack of manufacturing capacity for commercial-scale gene therapy production and viral-vector manufacturing has led to the opening of a wide number of CDMOs and in-house facilities for gene therapy manufacturing. This is anticipated to build profitable opportunities for the players.
The need to treat rare genetic diseases, enhance quality of life, and unlock the next wave of treatment innovations is projected to promote the growth of the gene therapy market.  Various universities and institutes are home to a broad-ranging portfolio of products in the pipeline. In addition, several researchers are…

Both liquid and semi-solid formulations require a series of steps during the preparation process to ensure the quality and stability of the final product.
Similarities and Differences Between Liquid Formulation and Semi-solid Formulation Both liquid and semi-solid formulations require a series of steps during the preparation process to ensure the quality and stability of the final product. The similarities and differences between them are mainly reflected in the following aspects: Overall process: The preparation process of liquid preparations is usually more straightforward, which involves dissolving the drug in a solvent and completing the steps of mixing and stirring. The preparation process of semi-solid preparations requires more steps, such as mixing, heating, cooling, stir…

Global vascular patches market is projected to witness a CAGR of 6.97% during the forecast period 2024–2031F
Global vascular patches market is projected to witness a CAGR of 6.97% during the forecast period 2024–2031F, growing from USD 507.68 million in 2023 to USD 870.12 million in 2031F. The market has experienced significant growth in recent years and is expected to maintain a strong pace of expansion in the coming years. Vascular patches are used to treat aneurysms, arterial stenosis, and undesirable blood clots, in addition to reconstructing tissue or arteries in cardiovascular illnesses. Heart arteries (coronary arterial bypass), kidneys, legs (femoropopliteal bypass), and the abdominal aorta are the usual surgical sites. The increasing global prevalence of cardiovascular disorders is…

Transitioning from a Medical Doctor's traditional path to the world of a Freelance MedComms Consultant has been exciting and seasoned with opportunities. This shift has allowed me to leverage my extensive international medical training, teaching, and biomedical research experience and introduced me to a world where flexibility, continuous learning, and building long-standing client relationships are paramount.
Transitioning from a Medical Doctor's traditional path to the world of a Freelance MedComms Consultant has been exciting and seasoned with opportunities. This shift has allowed me to leverage my extensive international medical training, teaching, and biomedical research experience and introduced me to a world where flexibility, continuous learning, and building long-standing client re…

Different techniques have been developed to functionalize nanotubes, including covalent and non-covalent approaches.
Nanotubes, with their unique properties and structure, have revolutionized various fields of science and technology. Over the past few decades, tremendous efforts have been made to functionalize nanotubes, unlocking their true potential for a wide range of applications. Understanding Functionalization of Nanotubes Functionalization refers to the process of modifying the surface properties of nanotubes, enabling them to interact with specific molecules or materials. This modification plays a crucial role in tailoring the physical and chemical properties of nanotubes, making them suitable for a variety of applications. Different techniques have been developed to functionalize…

In the recruitment sector, having a specialist by your side makes all the difference. Our dedicated team combines industry savvy with the skills and a personalised touch to deliver results that matter. Find out more!
At Amanda Wright, we're proud to be not just another recruitment agency. We're your strategic partner in the fast-paced, ever-changing world of Recruitment to Recruitment (Rec2Rec). Our mission? To bridge the gap between extraordinary talent and the agencies that need them.  In the recruitment sector, having a specialist by your side makes all the difference. Our dedicated team combines industry savvy with the skills and a personalised touch to deliver results that matter.      Our team is highly experienced and passionate about Rec2Rec. This passion drives…

A recent poll conducted among clinical trial professionals has highlighted the most significant trends expected to transform the industry over the next five years
A recent poll conducted among industry professionals reveals significant insights into the evolving landscape of clinical trials. With 70% of respondents identifying increased use of AI and machine learning (ML) as the biggest trend, it is clear that integrating advanced technologies will play a pivotal role in shaping the future of clinical trials. Other notable trends include the rise of decentralized trials (14%), enhanced patient engagement tools (13%), and regulatory harmonization (4%). The Future of Clinical Trials: Key Trends As the clinical trials industry evolves, it faces numerous challenges, including data management in…

In a snap analysis of the social media conversations of healthcare professionals following the news that the NHS has launched its world-first personalised cancer vaccination programme, Creation Healthcare found that, while the response was overwhelmingly positive, some apprehension remained that vaccine hesitancy and anti-vax sentiment could hinder uptake among patients.
Healthcare professionals across the globe have reacted “overwhelmingly positively” to news that thousands of NHS patients in England will be fast-tracked onto a world-first personalised cancer vaccine scheme.  In a snap analysis following the breaking news, leading digital insights consultancy Creation Healthcare found that online healthcare professionals heralded the vaccine as a “game changer”, although som…

Babies who cannot access breast milk are one step closer to benefitting from a pioneering microbiome supplement that will provide them with the crucial microbes required for healthy development.
That’s after the healthcare startup BoobyBiome collaborated with technology innovation centre, CPI. to scale-up their cutting-edge bacterial supplement.  The organisations have announced that the collaboration has brought the supplement closer to commercial reality.  The supplement contains live bacteria identified and sourced from the microbiomes of donated breast milk that can boost the immune systems of babies whose mothers cannot breastfeed.  The product can be added to formula milk, or breast milk for babies who require additional support to improve gut health and develop their…

The collaboration between the Centre for Process Innovation (CPI), academia, and industry leaders within pharma and digital could help medicines reach patients up to a year faster (30 April 2024).
The collaboration will develop a working model of a cloud-first manufacturing facility that will use technologies such as artificial intelligence (AI), machine learning and the Internet of Things (IoT) to accelerate the speed at which new medicines are made.  Using these technologies in pharma could lead to patients gaining faster access to innovative treatments and could reduce operational costs for manufacturers by up to 30 per cent.  Alongside cost reduction, digital manufacturing technologies also allow greater agility to scale production and meet changing demand, with som…

Non-coding RNAs (ncRNAs) are RNA molecules that cannot be translated into proteins. ncRNAs are found in a wide range of organisms and serve a number of roles. Transfer RNAs (tRNAs) are traditional noncoding RNAs (ncRNAs) that transform genetic information from messenger RNA (mRNA) to amino acid sequence information in nascent proteins.
Non-coding RNAs (ncRNAs) are RNA molecules that cannot be translated into proteins. ncRNAs are found in a wide range of organisms and serve a number of roles. Transfer RNAs (tRNAs) are traditional noncoding RNAs (ncRNAs) that transform genetic information from messenger RNA (mRNA) to amino acid sequence information in nascent proteins.   The anticodon loop of tRNAs may be precisely spliced into tRNA halves under the influence of sex hormone, hypoxia…

With the development of next-generation sequencing (NGS) technologies and new sequencers, the exponential growth of biological information generated by the scientific community has brought benefits as well as new challenges to researchers. In the era of big data, the field of bioinformatics has made significant progress in the analysis and interpretation of biological data. Therefore, there is a need to develop computational techniques and tools for effective data analysis and visualization to help understand biological processes.
With the development of next-generation sequencing (NGS) technologies and new sequencers, the exponential growth of biological information generated by the scientific community has brought benefits as well as new challenges to researchers. In the era of big data,…

Bioinformaticsis a rapidly evolving field filled with a plethora of tools for processing and manipulating next-generation sequencing (NGS) data. The performance of NGS alignment tools continues to improve, but it now takes more time to sort aligned data than to align it. SAMtools and sambamba are two commonly used tools for sorting binary alignment map (BAM) files.
Bioinformaticsis a rapidly evolving field filled with a plethora of tools for processing and manipulating next-generation sequencing (NGS) data. The performance of NGS alignment tools continues to improve, but it now takes more time to sort aligned data than to align it. SAMtools and sambamba are two commonly used tools for sorting binary alignment map (BAM) files.   SAMtools SAMtools, developed by the 1000 Genomes…

Whole genome bisulfite sequencing (WGBS) converts unmethylated cytosine (C) to thymine (T) with the bisulfite treatment on genomic DNA. Subsequently, whole genome resequencing of the treated DNA and comparison with the reference genome were performed to achieve single-base resolution and high-accuracy methylation level analysis from the genomic level.
DNA methylation is an important component of epigenetics and plays an important role in maintaining normal cellular function, genetic imprinting, embryonic development, and human tumorigenesis. Whole genome bisulfite sequencing (WGBS) converts unmethylated cytosine (C) to thymine (T) with the bisulfite treatment on genomic DNA. Subsequently, whole genome resequencing of the treated DNA and comparison with the…

RNA methylation stands as a pivotal focus within the realm of epigenetics. With a repertoire exceeding 100 distinct modifications, notable examples include methylation, hydroxymethylation, and acetylation. Among these, m6A stands as the most prevalent methylation modification on RNA, averaging 1 to 3 m6A modifications per transcript.
RNA methylation stands as a pivotal focus within the realm of epigenetics. With a repertoire exceeding 100 distinct modifications, notable examples include methylation, hydroxymethylation, and acetylation. Among these, m6A stands as the most prevalent methylation modification on RNA, averaging 1 to 3 m6A modifications per transcript. Ubiquitous across eukaryotes, encompassing mammals, insects, plants, yeast, and select viruses, m6A occurs not only on mRNA…