Articles

With patients demanding more control over their health, patient-centered care has recently become the main trend in healthcare service delivery. But to make informed decisions, patients need to have a better insight into their health, which means they need to have access to their health records. At the same time, medical professionals also want to have patients’ health histories at hand to tailor care to particular patients and their unique needs.
This makes electronic health records one of the key tools in patient-centric healthcare. According to PEW research, 61% of US patients want to be able to access their medical records via a mobile device or an online patient portal. The same study states that most respondents also agree that clinicians should be able to easily exchange patients’ in…

On Thursday the 23 November 2023, the PDA Ireland Chapter hosted an event on Microbiology – The Key to Compliance with Annex 1 and Risk Based Regulations. This sold-out event was led by industry leaders, experts, regulators, and pharmaceutical company representatives and was attended by professionals from across Ireland as well as overseas. The latest revision of the Annex 1 came into force in August 2023 and remains a hot topic within the industry.
On Thursday the 23 November 2023, the PDA Ireland Chapter hosted an event on Microbiology – The Key to Compliance with Annex 1 and Risk Based Regulations. This sold-out event was led by industry leaders, experts, regulators, and pharmaceutical company representatives and was attended by professionals from across Ireland as well as overseas. The…

Life Sciences manufacturing has experienced a demanding year, with continued pressure to innovate, reduce costs and overcome global supply chain disruption through improved visibility and contingency planning. These will continue to be priorities over the coming year, which will also bring new challenges, outlined by REPHINE’s Dr. Eduard Cayón.
2023 has been a demanding year for Life Sciences manufacturing, with continued pressure to innovate, bring costs down and overcome very real global supply chain disruption through improved visibility and contingency planning. The most significant and serious pharma R&D projects are concentrated in the biotech space now. Although small-molecule developments are still a focus of investment, this once dominant field is becoming steadily less strateg…

Here, we’ve compiled a list of life science recognition and awareness days taking place in 2024.
Here, we’ve compiled a list of life science recognition and awareness days taking place in 2024. Read the full article on PharmiWeb.Jobs.

As we celebrate 25 years of PharmiWeb, we wanted to summarise some of the key ways we can help you to locate and engage top life science talent. Whether you’ve been partnering with us for years or are discovering us for the first time, this list of 25 services, features and free resources will ensure you’re getting the most out of our platforms.
As we celebrate 25 years of PharmiWeb, we wanted to summarise some of the key ways we can help you to locate and engage top life science talent. Whether you’ve been partnering with us for years or are discovering us for the first time, this list of 25 services, features and free resources will ensure you’re getting the most out of our platforms. Read the full article on PharmiWeb.Jobs.

In this article, we look at 25 of the most transformative milestones in the life science industry over this period, from decoding the human genome to the celebration of the 75th birthday of the NHS.
Over the past 25 years, the life science industry has witnessed an array of groundbreaking achievements that have revolutionised human health, fuelled industry expansion, and propelled innovation in healthcare, clinical research, biotechnology, and medical devices. In this article, we look at 25 of the most transformative milestones in the life science industry over this period, from decoding the human genome to the celebration of the 75th birthday of the NHS. Read the full article on PharmiWeb.Jobs.

In this article, we’ve rounded up some of the most significant predictions on what life sciences could look like by 2050, with insights presented by futurologists and life science experts.
As we celebrate PharmiWeb turning 25, we’ve been reflecting on just how much the life science industry has transformed over the past quarter century, and imagining what it will look like in another 25 years’ time. In this article, we’ve rounded up some of the most significant predictions on what life sciences could look like by 2050, with insights presented by futurologists and life science experts.  Read the full article on PharmiWeb.Jobs.

The preparation of microspheres by spray drying method is a method of spraying the liquid raw excipients into the hot drying medium to convert the raw excipients into dry powder in the spray dryer.
Microsphere Preparation Steps The preparation of microspheres by spray drying method is a method of spraying the liquid raw excipients into the hot drying medium to convert the raw excipients into dry powder in the spray dryer. The specific preparation process can be divided into three steps: the atomizer atomizes the original excipient solution into small droplets; the drying gas cures and dries the small droplets; and the dry particles are separated from the drying medium. Advantages of Spray Drying Technology Applicable to a variety of drugs, especially protein and peptide drugs with biol…

CRISPR-Cas9 is a gene editing technology that has changed the landscape of biological research. It stands for Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-Associated Protein 9. CRISPR-Cas9 uses a two-component system consisting of a guide RNA (gRNA) and a Cas9 protein. The gRNA is designed to complement specific target sequences in the genome to guide the Cas9 protein to the desired location. Once the Cas9 protein reaches the target site, it causes a double-strand break in the DNA helix, which initiates a cellular repair process that can lead to gene modification or insertion.  Explore with our CRISPR Screen Sequencing Data Analysis Service and CRISPR Validation Sequencing Data Analysis Service for more information.
What is CRISPR-Cas9? CRISPR-Cas9 is a gene edi…

Nanopore sequencing, a pivotal component of long-read sequencing technology, has emerged as a formidable and promising approach in the realm of genomics and molecular biology. Spearheaded by the Oxford Nanopore Company, this innovative technology bears the potential to revolutionize genomic research and clinical applications.
  Nanopore sequencing, a pivotal component of long-read sequencing technology, has emerged as a formidable and promising approach in the realm of genomics and molecular biology. Spearheaded by the Oxford Nanopore Company, this innovative technology bears the potential to revolutionize genomic research and clinical applications.   The fundamental principle of nanopore sequencing revolves around the passage of individual DNA or RNA molecules through nanometer-s…

MicroRNAs (miRNAs) are a class of small endogenous non-coding RNAs of about 22 nt in length, with hairpin structures as precursors, which are widely found in animal, plant and viral organisms. Numerous studies have shown that miRNAs are involved in a wide range of biological processes, including cell proliferation, apoptosis, differentiation, metabolism, tumor and growth development, as well as in response to stress (including drought, high salt and nutrient stress).
What is Degradome Sequencing? MicroRNAs (miRNAs) are a class of small endogenous non-coding RNAs of about 22 nt in length, with hairpin structures as precursors, which are widely found in animal, plant and viral organisms. Numerous studies have shown that miRNAs are involved in a wide range of biological processes, including ce…

A fusion gene is a chimeric gene formed by the fusion of partial sequences of two genes, usually due to chromosomal translocations or deletions. These chimeric genes can form abnormal transcripts or proteins in subsequent biological processes, which can lead to or promote the development of tumors.
What is fusion gene? What is Chimeric RNAs? A fusion gene is a chimeric gene formed by the fusion of partial sequences of two genes, usually due to chromosomal translocations or deletions. These chimeric genes can form abnormal transcripts or proteins in subsequent biological processes, which can lead to or promote the development of tumors.   For example, in chronic granulocytic leukemia, molecular biology is characterized by the detection of a BCR-ABL fusion gene; this fusion gene translat…

Experimental design plays a crucial role in various research areas, providing a systematic framework for conducting experiments and obtaining reliable and interpretable results. Experimental design is critical, especially when trying to avoid attrition bias.
Experimental design plays a crucial role in various research areas, providing a systematic framework for conducting experiments and obtaining reliable and interpretable results. Experimental design is critical, especially when trying to avoid attrition bias.   Components of Experimental Design Within the realm of scientific inquiry, the formulation of a rigorous experimental design necessitates a profound comprehension of its intricate components and their interrelationships. To embark upon such a design, the foremost task ent…

AI in drug discovery has revolutionized the pharmaceutical industry by accelerating the process of drug development, making it more efficient and cost-effective. It combines advanced algorithms, machine learning, and big data analysis to expedite the identification of potential drug candidates and optimize their properties.
One significant area where AI shines is in predicting molecular properties and interactions. Machine learning models can analyze vast datasets of molecular structures, biological data, and chemical properties to predict how a compound might interact with specific targets in the body. This predictive power expedites the identification of potential drug candidates, saving considerable time and resources in the initial stages of drug discovery. Additionally, AI enables the…

Cytokines are small molecular peptides or glycoproteins synthesized and secreted by a variety of tissue cells, mainly immune cells. Cytokines mediate cellular interactions and have a variety of biological functions that can be involved in immune diseases, inflammation, and infectious diseases. Some cytokines play a positive role in metabolic activities, while others have negative metabolic effects related to the induction of metabolic dysfunction.
Cytokines are small molecular peptides or glycoproteins synthesized and secreted by a variety of tissue cells, mainly immune cells. Cytokines mediate cellular interactions and have a variety of biological functions that can be involved in immune diseases, inflammation, and infectious diseases. Some cytokines play a positive role in metabolic activ…

The application of HPLC in the field of anti-counterfeiting drugs has developed rapidly. Counterfeit drugs and inferior drugs are one of the important issues that plague the development of global drugs, and they have been taken seriously by governments of various countries. About 6% of drugs in global drug sales are counterfeit and inferior products. HPLC is one of the most effective testing instruments for the crackdown on counterfeit and inferior drugs.
In recent years, high-performance liquid chromatography (HPLC) has been used more and more widely in conventional drug analysis and detection. The 1975 edition of the "United States Pharmacopeia" (19th edition) included HPLC as a standard analysis method for the first time, and there were only 6 varieties at that time. By the 20t…

Some carotenoids have shorter (C30) or longer (C45 or C50) side carbon chains and are usually divided into two classes: xanthophylls and carotenes. In nature, more than 1100 carotenoids have been found, the common ones are lycopene, a-carotene, β-carotene, astaxanthin, lutein, zeaxanthin, cryptoxanthin and violet xanthin. 
Carotenoids are lipophilic natural pigments synthesized by all photosynthetic organisms and some non-photosynthetic prokaryotes and fungi. Typical carotenoids are C40 mushroom compounds and their derivatives consisting of eight isoprene units linked end to end. Some carotenoids have shorter (C30) or longer (C45 or C50) side carbon chains and are usually divided into two classes: xanthophylls and carotenes. In nature, more than 1100 carotenoids have been found, the co…

Anthocyanin is one of the important pigments that determine the color of flowers, fruits and seed coats of angiosperms. It is found in the vesicles of plant epidermal cells and appears orange, red to blue. Anthocyanins also play an important role in plant resistance to stress.
Structure and classification of anthocyanins The basic structure of anthocyanins is an α-phenylchroman cation with a basic C6 (A ring)-C3 (C ring)-C6 (B ring) carbon skeleton structure. Due to the methylation and hydroxylation modifications occurring at different positions on the ring, mainly for the different groups at the R1 and R2 positions on the B ring, different anthocyanin species are formed. There are at least 650 anthocyanins identified in nature. Despite the increasing number of anthocyanin structures, they…

Auxin is the most important class of hormones in plants, and its asymmetric distribution pattern in plants regulates the developmental processes of plant cells and tissues, including cell division, cell elongation, landwardness, apical dominance, plant flowering and leaf order development, primary root development and lateral root genesis, senescence, and various stress responses.
Auxin is the most important class of hormones in plants, and its asymmetric distribution pattern in plants regulates the developmental processes of plant cells and tissues, including cell division, cell elongation, landwardness, apical dominance, plant flowering and leaf order development, primary root development and lateral root genesis, senescence, and various stress responses.   The endogenous growth…

In the realm of biochemistry, one enzyme that has shown significant medical implications is proline dipeptidase, also known as prolidase. At Creative Enzymes, we have successfully isolated this enzyme from its biological host, pig (porcine tissue), and have cataloged it as Native Porcine Prolidase.
In the realm of biochemistry, one enzyme that has shown significant medical implications is proline dipeptidase, also known as prolidase. At Creative Enzymes, we have successfully isolated this enzyme from its biological host, pig (porcine tissue), and have cataloged it as Native Porcine Prolidase.   Native Porcine Prolidase, also called peptidase D, is an enzyme catalyzing the splitting of dipeptides with a proline or hydroxyproline residue in the C-terminal position. In other words, this e…