How does leaky Gut affect your Nervous System? And its best remediation

Both the Gut and nervous system communicate regularly through the "nervous system language" to perform the various functions. This useful interaction of Gut and the nervous system helps Gut to respond to the variety of dietary products that it absorbs, the broad spectrum of pathogens that it encounters, and the diverse microbiome that it harbors [1] To understand the Leaky gut syndrome, one need to get aware of Autonomic nervous system.

The autonomic nervous system is responsible for various body functions; ANS controls the blood flow throughout the gastrointestinal tract. It has two main types, the sympathetic and parasympathetic nervous systems. [2]

Role of CNS

The primary role of the sympathetic nervous system is to stimulate the body's fight-flight-or-freeze response and gives many physiological appearances and manifestations of tight clenching high pitch constipation. SNS prepares the body for immediate responses and quick actions. SNS swift response prepares the body to respond to an emergency or acute stress. [3]

The reaction of stress in the body is different for everyone and varies depending upon the stage of stress. Stress factor is highest among students who could not complete their assignments on time and they opt to get the assignment help. So in all stress-related issues like Cholesterol raise or high pulse rate, our body starts pumping various hormones and different neurotransmitters. So that's how the stress keeps our SNS stimulated.

Blood immune barriers like Neurovasculature in the brain prevent the small molecules and bacteria from entering the mind. External and internal stress impacts the activity of blood immune barriers. Likewise, intestinal blood barriers stop leakage of particles in the blood. But, the integrity of the intestinal blood barrier is compromised owe to a leaky Gut. External stress relays into the leaky Gut from where the particles leak into the bloodstream that causes the inflammatory response and immune response, which ultimately causes the burden to the body. [4]

Parasympathetic nervous system

Opposite to SNS, there is the parasympathetic nervous system which is responsible for the digestion and relaxation in the body. It is responsible for sexual arousal, bowel movements, the body, heals, sleep, and body to relax. The parasympathetic nervous system is also responsible for slowing the heart rate and contractility, bonding bronchial musculature, arousing bronchial excretions, and boosting gut motility to customize the digestion[5] The recovery from stress is accompanied by the parasympathetic nervous system, but sometimes, its over-activity can also contribute to stress reactions. Both SNS and PNS assist with the immune system and can modulate the stress reactions. [6] So, stresses that continue for an extended period stimulate SNS, and the response of SNS to counter the stress results in overall body wear and tear.

The human body is a kind of cycle. The reaction of SNS comes after the stress, and if it continues for a long time, there would be the creation of an acidic environment within the body and especially in the GI. This acidic environment in the GI leads to the formation of pathogenic

Bacteria and can affect several mammalian systems like the brain and digestive system. [7] Gut and brain work together for the proper functioning of CNS, but the imbalance microbial population leads to stressful situations. Under the specific conditions, these pathogens or small molecules can translocate and even reach CSF or other brain compartments by passing through the blood-brain barrier and causing anxiety and stress. [8]

To counter this situation, one needs to work on PNS. There are certain tricks or habits developed by the veteran to stimulate the PNS- so the body can naturally boost up the relaxation. By stimulating the PNS through various exercises, one can stop the continuous battle in the body.

References:

[1] Bryan B. Yoo1 Sarkis K.Mazmanian:

The Enteric Network: Interactions between the Immune and Nervous Systems of the Gut.

[2] Leandro PiresAraujo15 Juliana TerziMaricato1

The Sympathetic Nervous System Mitigates CNS Autoimmunity via β2-Adrenergic Receptor

[3] Georg Pongratz Rainer H Straub

The sympathetic nervous response in inflammation,

[4, 7, 8] Mark E. M. Obrenovich Leaky Gut, Leaky Brain?